Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det

用于提高 PET 检测中的定时和空间分辨率的光子带隙结构

基本信息

批准号：
8001023
负责人：
BIPIN SINGH
金额：
$ 18万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8001023
关键词：
Affect Area Businesses Cerium Characteristics Collaborations Collection Coupled Coupling Detection Development Devices Digital Mammography Digital Radiography Emission-Computed Tomography Environment Evaluation Event Functional Imaging Gel Goals LSO crystal Laboratories Length Light Lighting Liquid substance Lutetium Measurement Measures Mechanics Medical Technology Methodology Nanostructures Optics Outcome Output Patients Pennsylvania Performance Periodicity Phase Philadelphia Photons Physics Plague Positron-Emission Tomography Process Production Property Quantum Dots Radiation Radiology Specialty Refractive Indices Reporting Research Resolution Resources Roentgen Rays Semiconductors Silicon Solutions Source Specific qualifier value Staging Structure Surface System Techniques Technology Testing Time Travel Tube Universities Work Writing X-Ray Computed Tomography base cancer diagnosis commercial application density design detector electron beam lithography gallium arsenide imaging modality improved indexing instrumentation interest light emission molecular imaging nano nanofabrication nanoimprint lithography novel novel strategies photomultiplier photonics product development professor public health relevance quantum response self assembly sensor simulation solid state statistics time use tool transmission process

项目摘要

DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for cancer diagnosis, staging, treatment tracking and research. High resolution and high efficiency detectors used in imaging modalities such as PET widely use high density, high refractive index scintillators such as cerium-doped lutetium oxyorthosilicate (LSO: Ce). When such high refractive index scintillators are coupled to detectors such as photomultiplier tubes (PMT) or avalanche photodiodes (APD), the mismatch in the refractive index of the scintillator and the detector cause only a small fraction of the light generated within the scintillator to exit the surface of the scintillator, and thereby be sensed by the photodetector. The use of a coupling fluid or gel between the scintillator and the detector helps only marginally. The proposed research will use recent advancements in nanofabrication techniques for creating photonic band gap structures to enhance the light extraction efficiency of scintillators, thereby improving the time and energy resolutions of PET detectors. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. High density, high refractive index scintillators currently used in positron emission tomography (PET) detectors are often plagued by an inefficient extraction of the scintillation light that results in inaccuracy (often significant) in event coincidence timing sufficient to affect spatial resolution. The goal of the proposed research is to demonstrate the feasibility of using novel photonic band gap structures to improve timing and spatial resolution in PET detectors by the efficient extraction of scintillation light from such high density, high refractive index scintillators.

描述（由申请人提供）：与光电倍增管或硅二极管耦合的闪烁晶体是用于 X 射线/3 射线检测的最常见探测器。正电子发射断层扫描 (PET)、单光子发射计算机断层扫描 (SPECT)、数字放射线摄影（包括数字乳房 X 线摄影）和 X 射线 CT 等成像方式对于癌症诊断、分期、治疗跟踪和研究至关重要。用于 PET 等成像方式的高分辨率和高效探测器广泛使用高密度、高折射率闪烁体，例如掺铈氧原硅酸镥 (LSO: Ce)。当这种高折射率闪烁体与光电倍增管（PMT）或雪崩光电二极管（APD）等探测器耦合时，闪烁体和探测器折射率的不匹配仅导致闪烁体内产生的一小部分光射出闪烁体的表面，从而被光电探测器感测到。在闪烁体和探测器之间使用耦合流体或凝胶的帮助仅很小。拟议的研究将利用纳米制造技术的最新进展来创建光子带隙结构，以提高闪烁体的光提取效率，从而提高 PET 探测器的时间和能量分辨率。公共卫生相关性：项目叙述与光电倍增管或硅二极管耦合的闪烁晶体是用于 X 射线/3 射线检测的最常见探测器。目前正电子发射断层扫描 (PET) 探测器中使用的高密度、高折射率闪烁体经常受到闪烁光提取效率低下的困扰，从而导致事件符合定时的不准确（通常很严重），足以影响空间分辨率。拟议研究的目标是证明使用新型光子带隙结构通过从这种高密度、高折射率闪烁体中有效提取闪烁光来提高 PET 探测器的时间和空间分辨率的可行性。