ENERGY EXPENDITURE RESPONSES TO ACUTE AND CHRONIC EXERCISE IN OLDER WOMEN

老年女性的能量消耗对急性和长期运动的反应

• 批准号: 8463649
• 负责人: Xuewen Wang
• 金额: $ 24.5万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463649
• 关键词: Acute; Address; Aerobic; Aerobic Exercise; Aging; Basal metabolic rate; Biological Factors; Blood; Blood Pressure; Body Weight; Chronic; Disease; Dose; Elderly; Energy Metabolism; Exercise; Exhibits; Expenditure; Health; Indirect Calorimetry; Individual; Instruction; Label; Leptin; Lipids; Measures; Monitor; Non obese; Obesity; Outcome; Oxygen Consumption; Phase; Physical activity; Physiological; Plasma; Potential Energy; Randomized; Research; Research Project Grants; Serum; System; Techniques; Thermogenesis; Thyronines; Water; Weight Gain; Woman; energy balance; feeding; fitness; insulin sensitivity; older women; post intervention; programs; response; thyronine

Weight gain with aging and its potential resultant obesity are significant health concerns in older individuals. Evidence suggests that compensatory changes in energy expenditure (EE) occur in response to periods of altered energy balance, which nnay be pronounced in older adults. Inducing an energy deficit by exercise is an important strategy to treat obesity; however, it is not known whether there is an optimal exercise prescription that maximizes total daily EE, perhaps by minimizing the reduction in activity EE other than the energy expended during exercise program that may occur in response to exercise participation. Moreover, the physiological mechanisms regulating EE changes in response to altered energy balance are not known. The study presented in this ROO application will help to address these questions by determining whether dose of exercise programs influences changes in EE and potential energy-regulatory biological factors in older women. The specific aims of the proposed research are to determine whether differential changes occur in total daily EE and its components in response to exercise programs of two different doses. Women (60-75 years) will be randomized to 16-week aerobic exercise programs of 8 or 14 kcal/kg body weight per week. State-of-the-art techniques will be used to measure total daily EE (using doubly labeled water) and its components (resting metabolic rate, thermic effect of feeding via indirect calorimetry, and non-exercise activity EE using the Physical Activity Monitoring System) at baseline and post-intervention. We hypothesize that women will exhibit a smaller increase in total daily EE in response to the higher-dose, compared to the lower-dose exercise program, due to a greater decline in non-exercise activity EE. We will also determine whether differential changes occur in blood concentrations of potential energy-regulatory factors, such as leptin and free T3, and variables related to cardiometabolic diseases, including plasma lipids, insulin sensitivity, blood pressure, aricj aerobic fitness after the exercise programs of different doses.

随着衰老及其潜在的肥胖，体重增加是老年人的重大健康问题。 有证据表明，能源支出的补偿性变化（EE）响应于 改变能量平衡，在老年人中发音。通过锻炼引起能量不足是 治疗肥胖症的重要策略；但是，尚不知道是否有最佳练习 最大化每日总EE的处方，也许是通过最大程度地减少活动EE的减少 在运动计划中消耗的能量可能是为了响应锻炼参与而发生的。而且， 尚不清楚调节EE的变化而调节EE的变化的生理机制尚不清楚。 在此ROO应用中介绍的研究将通过确定是否是否确定是否有助于解决这些问题 运动计划的剂量影响EE的变化和势能调节生物学因素 老年妇女。拟议研究的具体目的是确定差异是否变化 每日EE及其组成部分发生在两种不同剂量的运动计划中。女性 （60 - 75年）将随机分为8或14 kcal/kg体重的16周有氧运动计划 星期。最先进的技术将用于测量每日总EE（使用双重标记的水）和 它的成分（静息代谢率，通过间接量热法喂养的热效应和非运动 在基线和干预后使用体育活动监测系统的活动EE。我们 假设妇女对高剂量的响应，每天的总EE的增长较小， 与下剂量运动计划相比，由于非运动活性EE的下降越来越大。我们将 还确定势能调节的血液浓度中是否发生差异变化 因素，例如瘦素和游离T3，以及与心脏代谢性疾病有关的变量，包括等离子体 脂质，胰岛素敏感性，血压，不同剂量运动后的Aricj有氧运动。