Gastrointestinal Oncology

胃肠道肿瘤学

基本信息

批准号：
8300280
负责人：
MAX S. WICHA
金额：
$ 16.91万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8300280
关键词：
Basic Science Biological Biological Markers Biological Products Cancer Center Support Grant Cancer Patient Cancer-Predisposing Gene Carcinoma Cells Cholangiocarcinoma Clinical Clinical Research Colorectal Cancer Combined Modality Therapy Development Diagnosis Discipline Early Diagnosis Epidemiology Evaluation Funding Gastrins Gastroenterology Gastrointestinal Neoplasms Gene Expression Profile Genes Goals Grant Health Helicobacter pylori Hepatic Human Immunotherapy Inflammation Interventional radiology Intestines Investigation Liver Liver neoplasms Malignant neoplasm of gastrointestinal tract Malignant neoplasm of pancreas Medical Oncology Michigan Modality Molecular Mutation Neoadjuvant Therapy Neoplasm Metastasis Operative Surgical Procedures Outcome Outcomes Research Patients Phenotype Play Population Prevention Primary carcinoma of the liver cells Radiation Radiation Oncology Recruitment Activity Research Resectable Role Schools Signal Transduction Pathway Therapeutic Translational Research Universities University of Michigan Comprehensive Cancer Center Unresectable anticancer research base cancer prevention cell growth clinical care diagnosis evaluation gastrointestinal health care quality improved malignant stomach neoplasm member mouse model multidisciplinary novel novel diagnostics oncology oncology program pancreatic cancer cells programs stem cell differentiation translational study tumor tumorigenesis

项目摘要

The Gastrointestinal Oncology Program Is a comprehensive program in gastrointestinal cancer research encompassing basic research, clinical and translational research. The program consists of 39 members from 9 different departments and two schools within the University of Michigan, receiving $9 million in annual direct support, Including $4.4 in NCI funding. The GI grant portfolio includes a $2.1 M SPORE grant to study colorectal and pancreatic cancer, two PO1 grants, U01 and U19 grants. The program is focused on the development of fundamental basic research into the causes and prevention of human gastrointestinal cancers and translational studies applying these research findings to improve the early and accurate diagnosis, evaluation, and therapeutic approaches to gastrointestinal cancer as well as Issues related to health quality outcomes, The basic research alms of the Gastrointestinal Oncology Program focus on mechanisms of cell growth and differentiation, stem cells and cell metastasis. The clinical research focuses on neoadjuvant therapies and biomarkers. The outcome research focuses on health care quality Issues. Nine new program members recruited over this grant period include Drs Marwan Fakih, Weiping Zou, Grace Chen, Chandan Kumar, Marina Pasca Di Magliano, Patrick Hu, Gazala Khan, Theodore Welling, and John Carethers. This program, which was rated as

胃肠肿瘤学项目是胃肠道癌症研究的综合项目，包括基础研究、临床和转化研究。该计划由来自密歇根大学 9 个不同院系和两所学院的 39 名成员组成，每年获得 900 万美元的直接支持，其中包括 4.4 美元的 NCI 资助。 GI 拨款组合包括用于研究结直肠癌和胰腺癌的 210 万美元 SPORE 拨款、两项 PO1 拨款、U01 和 U19 拨款。该项目的重点是发展人类胃肠道癌症的病因和预防的基础研究，以及应用这些研究成果的转化研究，以改善胃肠道癌症以及与健康相关的问题的早期和准确的诊断、评估和治疗方法。胃肠肿瘤学项目的基础研究重点关注细胞生长和分化、干细胞和细胞转移的机制。临床研究重点是新辅助疗法和生物标志物。结果研究的重点是医疗保健质量问题。在此资助期内招募的九名新项目成员包括 Marwan Fakih 博士、Weiping Zou、Grace Chen、Chandan Kumar、Marina Pasca Di Magliano、Patrick Hu、Gazala Khan、Theodore Welling 和 John Carethers。该节目被评为