Biostatics

生物静力学

基本信息

批准号：
7945078
负责人：
DANIEL J. SARGENT
金额：
$ 56.94万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-17 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7945078
关键词：
Address Adverse event American Association of Cancer Research American Society of Clinical Oncology American Society of Hematology Area Basic Science Bibliography Biostatistics Shared Resource Cancer Center Support Grant Cancer Patient Case-Control Studies Characteristics Clinical Clinical Data Update System Clinical Research Clinical Trials Clinical Trials Data Monitoring Committees Cohort Studies Collaborations Collection Complex Comprehensive Cancer Center Conduct Clinical Trials Data Analyses Data Collection Data Element Data Quality Data Set Databases Development Disease Doctor of Philosophy Elements Eligibility Determination Ensure Epidemiologic Studies Epidemiologist Evolution Faculty Family Family Caregiver Funding Genetic Genomics Goals Grant Housing Human Resources Image Individual Intervention Laboratories Lead Learning Life Link Malignant Neoplasms Manuscripts Mayo Clinic Cancer Center Measurement Molecular Epidemiology Monitor Observational Study Outcome Patients Peer Review Phase Physicians Pilot Projects Policies Population Sciences Principal Investigator Procedures Process Proteomics Protocols documentation Publications Quality Control Quality of life Recording of previous events Reporting Research Research Activity Research Personnel Research Project Grants Resolution Resource Sharing Resources SKIL gene Sample Size Sampling Scientist Services Specialist Specimen Statistical Methods Surveys System Time Translational Research United States National Institutes of Health Work Writing anticancer research biomathematics cohort computerized data processing data management design interest mathematical model meetings member population based programs protocol violation psychosocial public education repository research study response sound tool web site

项目摘要

The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC) has provided expert statistical collaboration with MCCC investigators for over 35 years. The purpose is to provide statistical and biomathematical collaboration for the development and conduct of peer-reviewed cancer research generated by MCCC investigators. Research encompasses basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of CCSG funds is to support statistical and biomathematical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Over its history the BSR has undergone a natural and deliberate evolution and expansion, spurred by the expanding research activities of the MCCC. In the current grant period the BSR has successfully and strategically expanded in two primary areas: high dimensional genomic and proteomic data analysis (4 new faculty with this expertise), and to all 3 MCCC campuses. BSR faculty are physically located on all 3 MCCC campuses, and the entire resource communicates regularly and effectively through multiple mechanisms to ensure coordinated collaboration. The BSR has multiple focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, interventional psychosocial research, and patient and public education research projects, (II) a Population Science team responsible for providing statistical collaboration and data management support for cancer observational studies, including genetic and molecular epidemiology, (III) a Quality of Life team responsible for providing general and specific collaboration, measurement tools, and analysis for MCCC investigators investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others, and (IV) a Biomathematics team that provides collaborative expertise in the mathematical aspects of imaging, data processing and analysis, mathematical modeling of diease processes, and general mathematical or algorithmic issues. The BSR provides statistical and biomathematical collaboration to MCCC investigators across all three MCCC campuses. The resource has been remarkably productive, with 528 peer reviewed publications in the current grant period, and has collaborated on 104 NIH or NIH equivalent grants in the current grant period.

梅奥诊所癌症中心 (MCCC) 的生物统计共享资源 (BSR) 提供了专家与 MCCC 研究人员的统计合作已超过 35 年。目的是提供统计和为开发和开展同行评审的癌症研究而进行的生物数学合作 MCCC 调查员。研究包括基础科学、临床试验、流行病学研究和其他转化和教育研究。 CCSG 资金的主要用途是支持统计和试点项目上的生物数学合作，以协助研究人员开发批准的没有其他资助但导致外部资助的研究项目，并支持意外的 MCCC 批准项目的统计合作需求。 BSR 在其历史上经历了在 MCCC 不断扩大的研究活动的推动下，自然而刻意的演变和扩张。在当前的资助期内，BSR 已成功地在两个主要领域进行了战略性扩展：三维基因组和蛋白质组数据分析（4 名具有此专业知识的新教师），以及所有 3 个 MCCC 校园。 BSR 教职人员分布在 MCCC 的所有 3 个校区，并且整个资源通过多种机制定期有效沟通，确保协调协作。 BSR 将多个重点领域（团队）联系在一起，形成一个组织良好、高效的核心。它们是：（一）临床试验团队负责癌症临床试验、相关转化研究、介入治疗社会心理研究、患者和公共教育研究项目，(II) 人口科学团队负责为癌症观察提供统计协作和数据管理支持研究，包括遗传和分子流行病学，(III) 生活质量团队负责提供为调查 MCCC 调查人员提供的一般和具体协作、测量工具和分析临床和社会心理干预对癌症患者、家庭、护理人员和其他人的影响，以及 (IV) 生物数学团队，提供成像数学方面的协作专业知识，数据处理和分析、疾病过程的数学建模以及一般数学或算法问题。 BSR 为 MCCC 研究人员提供统计和生物数学协作横跨 MCCC 全部三个校区。该资源非常高效，有 528 个经过同行评审在当前资助期内发表论文，并在以下领域合作完成了 104 项 NIH 或 NIH 同等资助当前的资助期限。