Reversal Learning in Pediatric Bipolar Disorder

小儿双相情感障碍的逆转学习

基本信息

批准号：
7871008
负责人：
DANIEL P DICKSTEIN
金额：
$ 20.39万
依托单位：
EMMA PENDLETON BRADLEY HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7871008
关键词：
Adolescent Adult Aggressive behavior Alzheimer&apos s Disease Americas Amygdaloid structure Anxiety Disorders Applications Grants Attention deficit hyperactivity disorder Base of the Brain Behavior Behavioral Behavioral Paradigm Bipolar Disorder Brain Child Child Mental Health Comorbidity Corpus striatum structure Data Decision Making Diagnosis Diagnostic Diagnostic Specificity Differential Diagnosis Disease Doctor of Medicine Early Diagnosis Emotional Environment Event Experimental Designs Experimental Psychology Failure Functional Magnetic Resonance Imaging Functional disorder Goals Grant Health Care Costs Image Impairment Knowledge Laboratories Link Magnetic Resonance Imaging Maps Measures Mediating Methods Mission Morbidity - disease rate National Institute of Mental Health Neurobiology Neurologic Pharmaceutical Preparations Positioning Attribute Prefrontal Cortex Process Relative (related person)Reproduction Research Research Personnel Resolution Resources Reversal Learning Rewards Social Characteristics Source Specificity Stimulus Structure Symptoms Testing Time Training Ventral Striatum Work base behavior measurement brain behavior childhood bipolar disorder clinical Diagnosis clinically relevant disease classification emotion regulation expectation experience innovation meetings mortality neural circuit neuroimaging programs relating to nervous system response skills social treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Bipolar disorder (BPD) in a major source of morbidity and mortality for adults in America, with more than $24 billion spent annually; however, far less is known about BPD in children and adolescents. Emerging data shows that BPD children are impaired in reversal learning. This process requires behavioral adaptation to changing stimulus-reward contingencies and engages the ventral prefrontal cortex (vPFC), ventral striatum, and amygdala. My long-term goal is to understand how brain/behavior interactions, central to emotion regulation, differentiate normal from psychiatrically ill children, in order to develop more effective diagnostic and treatment strategies. The study of reversal learning will facilitate my efforts in this respect. The objectives of this application are to (1) acquire training in fMRI methods and experimental design, (2) identify neurological correlates of impaired reversal learning in pediatric BPD, and (3) develop an R01 application based on this work. My central hypothesis is that BPD children have specific impairments in reversal learning due to dysfunction in a neural circuit encompassing the vPFC, ventral striatum, and amygdala. To test this hypothesis, I will: (1) use fMRI to identify substrates of reversal learning in normal children; (2) determine functional neuroanatomical and behavioral differences in BPD children during reversal learning; (3) evaluate the specificity of reversal learning deficits in psychiatric controls. I will use the "response reversal" task developed by our group to evaluate reversal learning with 3 Tesla fMRI and behavioral data. This will be among the first studies to link behavioral dysfunction to brain abnormalities in children with strictly defined BPD. From these studies, I expect to determine that BPD children have selective alterations in fronto-temporal structures during reversal learning. The proposed work will positively impact child mental health advancing our knowledge of the underlying brain/behavior abnormalities mediating BPD in children and adolescents. In turn, greater pathophysiological understanding of pediatric BPD will move the field of pediatric BPD beyond symptom-based diagnosis, potentially allowing more accurate or earlier diagnosis, thus reducing the morbidity and mortality in children and adolescents suffering from this debilitating disorder.

描述（由申请人提供）：双相情感障碍 (BPD) 是美国成年人发病和死亡的主要根源，每年花费超过 240 亿美元；然而，人们对儿童和青少年边缘性人格障碍知之甚少。新数据显示，边缘性人格障碍儿童的逆向学习能力受到损害。这个过程需要行为适应不断变化的刺激奖励意外事件，并涉及腹侧前额叶皮层（vPFC）、腹侧纹状体和杏仁核。我的长期目标是了解作为情绪调节核心的大脑/行为相互作用如何区分正常儿童和精神疾病儿童，以便制定更有效的诊断和治疗策略。逆向学习的研究将有助于我在这方面的努力。此应用程序的目标是 (1) 获得功能磁共振成像方法和实验设计方面的培训，(2) 确定儿科 BPD 逆转学习受损的神经学相关性，以及 (3) 基于这项工作开发 R01 应用程序。我的中心假设是，由于包括 vPFC、腹侧纹状体和杏仁核的神经回路功能障碍，BPD 儿童在逆转学习方面存在特定障碍。为了验证这个假设，我将：（1）使用功能磁共振成像来识别正常儿童逆向学习的基础； (2)确定BPD儿童在逆向学习过程中的功能性神经解剖学和行为差异； (3) 评估精神科对照中逆转学习缺陷的特异性。我将使用我们小组开发的“反应逆转”任务，通过 3 Tesla fMRI 和行为数据来评估逆转学习。这将是首批将严格定义的 BPD 儿童的行为功能障碍与大脑异常联系起来的研究之一。从这些研究中，我希望确定边缘性人格障碍儿童在逆向学习过程中额颞叶结构有选择性的改变。拟议的工作将对儿童心理健康产生积极影响，增进我们对介导儿童和青少年 BPD 的潜在大脑/行为异常的了解。反过来，对儿科 BPD 的病理生理学更深入的了解将使儿科 BPD 领域超越基于症状的诊断，有可能实现更准确或更早的诊断，从而降低患有这种使人衰弱的疾病的儿童和青少年的发病率和死亡率。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cognitive performance of youth with primary generalized anxiety disorder versus primary obsessive-compulsive disorder.

患有原发性广泛性焦虑症和原发性强迫症的青少年的认知表现。

DOI：
发表时间：
2019
期刊：
影响因子：
7.4
作者：
Kim, Kerri L;Christensen, Rachel E;Ruggieri, Amanda;Schettini, Elana;Freeman, Jennifer B;Garcia, Abbe M;Flessner, Christopher;Stewart, Elyse;Conelea, Christine;Dickstein, Daniel P
通讯作者：
Dickstein, Daniel P

Altered neural function in pediatric bipolar disorder during reversal learning.

逆转学习期间小儿双相情感障碍的神经功能发生改变。

DOI：
发表时间：
2010-11
期刊：
影响因子：
5.4
作者：
Dickstein, Daniel P;Finger, Elizabeth C;Skup, Martha;Pine, Daniel S;Blair, James R;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen

Circadian Phase Preference in Pediatric Bipolar Disorder.

小儿双相情感障碍的昼夜节律相位偏好。

DOI：
发表时间：
2014-03-11
期刊：
影响因子：
0
作者：
Kim, Kerri L;Weissman, Alexandra B;Puzia, Megan E;Cushman, Grace K;Seymour, Karen E;Wegbreit, Ezra;Carskadon, Mary A;Dickstein, Daniel P
通讯作者：
Dickstein, Daniel P

Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies.

双相情感障碍的灰质差异：基于体素的形态测量研究的荟萃分析。

DOI：
发表时间：
2012-03
期刊：
影响因子：
5.4
作者：
Selvaraj, Sudhakar;Arnone, Danilo;Job, Dominic;Stanfield, Andrew;Farrow, Tom Fd;Nugent, Allison C;Scherk, Harald;Gruber, Oliver;Chen, Xiaohua;Sachdev, Perminder S;Dickstein, Daniel P;Malhi, Gin S;Ha, Tae H;Ha, Kyooseob;Phillips, Mary L;McIn
通讯作者：
McIn

Sensation Seeking in Children and Adults with Pediatric-Onset Bipolar Disorder.

患有儿科发作的双相情感障碍的儿童和成人的感觉寻求。

DOI：
发表时间：
2023-04-26
期刊：
影响因子：
2.9
作者：
Russo, Jillian M;Naclerio, Maria;Kaplan, Courtney;Cho, Emma;Lee, Eileen;Salisbury, Angela;Au, Josephine S;Tirpak, Julianne W;Dickstein, Daniel P
通讯作者：
Dickstein, Daniel P