Frontiers in Macromolecular Simulations Symposium

高分子模拟前沿研讨会

基本信息

批准号：
8438400
负责人：
Jere P Segrest
金额：
$ 4万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-11 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8438400
关键词：
Address Alabama Algorithms Applications Grants Biochemistry Biological Biological Sciences Biology Biomedical Engineering Biomedical Research Biophysics California Canada Caring Cell membrane Chemistry Chicago Commit Computers Databases Development Disabled Persons Electronic Mail Environment Enzymes Family Feedback Finland France Generations Genetic Transcription Goals Gray unit of radiation dose Human Genome Illinois Individual Institutes Investigation Journals Lipoproteins Medical Membrane Membrane Proteins Minority Molecular Molecular Biology Molecular Computers Molecular Genetics Molecular Models Newsletter North Carolina Pharmaceutical Preparations Pharmacology Physics Procedures Process Protein Dynamics Proteins Pump RNA Research Research Personnel Resources Ribosomal RNA Ribosomes Scientist Senior Scientist Series Signal Pathway Site Societies Structural Biochemistry Structural Biologist Structure Suggestion System Technology Texas Thinking Time Translations Universities Washington Woman Work abstracting base biological research computerized tools drug discovery falls frontier interest macromolecule medical schools meetings models and simulation molecular modeling multidisciplinary professor programs protein folding receptor simulation symposium theories transcription factor web site

项目摘要

DESCRIPTION (provided by applicant): 21st century biomedical research is being driven by the need for new drugs and procedures for solving humankind's most persistent and difficult medical problems. This research critically depends upon computer- intensive structure-based approaches to understand biological macromolecules and supramolecular assemblies in atomic detail. Progress is accelerating at a dizzying rate, and there is a critical need to promote integrative approaches driven by computational structural biologists. To help meet this challenge, our goal is to provide an environment for broadening the thinking of senior scientists, and, more important, to create a new diverse generation of theory-driven integrative scientists studying the structure and dynamics of proteins, membranes, lipoproteins, RNA and ribosomes. In this dual PI grant application, Jere Segrest (UAB) and Steve Harvey (Georgia Tech) are seeking 3 years support for an ongoing annual symposium entitled, "Frontiers in Macromolecular Simulations" that was held for the 6th time in the fall of 2009. For the past four years, the site of this symposium has alternated between UAB in Birmingham, AL and Georgia Tech in Atlanta, GA. The objective of our dual PI grant application is to hold a series of three annual conferences dedicated to fast breaking research in structure and dynamics of membranes, lipoproteins, proteins, RNA and ribosomes. Presentations at the proposed symposia will focus on theory-driven physics-based molecular modeling, simulations and experimentation. Biological research is increasingly multidisciplinary, and many experimental groups now routinely use sophisticated computational tools in their work. Our aim is to provide a venue in which application-oriented computational structural biologists will be exposed to the latest methodological advances (and provide feedback on suggested improvements), and in which experimentalists will have the opportunity to stimulate the thinking of computational biologists, both those who are primarily interested in applications, and those whose primary interest is the development of algorithms. We propose to hold the first of the three planned annual conferences for three days in March 30-April 1, 2011 at the Grand Hotel Marriott, Point Clear, Alabama. Approximately two-thirds of the platform speaker's slots will be reserved for membranes, lipoproteins and proteins and one-third for RNA and ribosomes. The two keynote speakers, Harry Gray, Professor of Chemistry, California Institute of Technology and Rachel Green, Professor of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, have agreed to join the two PIs in the organizing committee for the first conference. In addition to the keynote speakers, nine platform speakers, four women and one minority, have committed for the 2011 symposium. The second in the planned series of three conferences will be held off the Georgia Tech campus in the spring of 2012 at a still to be determined site in the State of Georgia. The final conference in the series will be held in the spring of 2013 at a neutral to be determined site in a third state, not necessarily in the Southeast.

描述（由申请人提供）：21 世纪的生物医学研究是由对解决人类最持久和最困难的医学问题的新药物和程序的需求推动的。这项研究主要依赖于基于计算机密集型结构的方法来了解生物大分子和超分子组装体的原子细节。进展正在以令人眼花缭乱的速度加速，迫切需要推广由计算结构生物学家驱动的综合方法。为了帮助应对这一挑战，我们的目标是提供一个拓宽资深科学家思维的环境，更重要的是，培养新一代多样化的理论驱动型综合科学家，研究蛋白质、膜、脂蛋白、 RNA 和核糖体。在这项双重 PI 资助申请中，Jere Segrest (UAB) 和 Steve Harvey (佐治亚理工学院) 正在为正在进行的题为“高分子模拟前沿”的年度研讨会寻求 3 年的支持，该研讨会于 2009 年秋季举行了第六次。在过去的四年里，本次研讨会的举办地点一直在阿拉巴马州伯明翰的阿拉巴马大学伯明翰分校和佐治亚州亚特兰大的佐治亚理工学院之间轮流举办。我们双重 PI 资助申请的目标是举办一系列三届年度会议，致力于膜、脂蛋白、蛋白质、RNA 和核糖体的结构和动力学的快速突破性研究。研讨会上的演讲将重点关注理论驱动的基于物理的分子建模、模拟和实验。生物学研究日益跨学科化，许多实验小组现在在工作中经常使用复杂的计算工具。我们的目标是提供一个场所，让面向应用的计算结构生物学家能够接触到最新的方法论进展（并提供有关改进建议的反馈），并且实验学家将有机会激发计算生物学家的思维，无论是那些主要对应用程序感兴趣的人和主要感兴趣的是算法开发的人。我们建议于 2011 年 3 月 30 日至 4 月 1 日在阿拉巴马州克利尔角万豪大酒店举行为期三天的三场年度会议中的第一场。平台扬声器的大约三分之二的插槽将保留用于膜、脂蛋白和蛋白质，三分之一用于RNA和核糖体。两位主讲人加州理工学院化学教授 Harry Gray 和约翰霍普金斯大学医学院分子生物学和遗传学教授 Rachel Green 已同意加入首届会议组委会的两位 PI 。除了主旨发言人外，还有 9 名讲台发言人（其中 4 名女性和 1 名少数族裔）已承诺参加 2011 年研讨会。计划中的三场会议系列中的第二场将于 2012 年春季在佐治亚理工学院校园外举行，地点尚未确定。该系列的最后一次会议将于 2013 年春季在第三个州（不一定是东南部）的一个待确定的中立地点举行。