RC5 STRESS-INDUCED DRINKING IN EMERGING ADULTS: THE ROLE OF TRAUMA HISTORY

RC5 新兴成年人中压力诱发的饮酒：创伤史的作用

基本信息

批准号：
8128142
负责人：
CARLA KMETT DANIELSON
金额：
$ 16.3万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8128142
关键词：
21 year old Acute Address Affect Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Alleles Auditory Behavior assessment Biological Blood Pressure Blood specimen Cessation of life Clinical Control Groups Corticotropin Counseling Data Dependence Diagnostic Distress Emotional Event Exposure to Funding Genes Genetic Genetic Polymorphism Goals Human Hydrocortisone Incidence Individual Injury Laboratories Laboratory Study Life Measures Mediating Neurosecretory Systems Participant Patient Self-Report Personality Traits Physiological Play Post-Traumatic Stress Disorders Preventive Intervention Procedures Psychopathology Randomized Reaction Recording of previous events Recruitment Activity Research Research Personnel Risk Role Serum Societies Stimulus Stress Target Populations Testing Time Trauma Trier Social Stress Test acute stress age group alcohol research alcohol response biological adaptation to stress career computerized cost design distress tolerance drinking drinking behavior emerging adult experience high risk indexing meetings neglect prevent promoter psychologic psychological stressor response serotonin transporter stressor treatment center young adult

项目摘要

Individuals exposed to a traumatic event at any time in their life, particularly those who develop posttraumatic stress disorder (PTSD), have a higher incidence of problematic drinking. However, little is known about the relationship between trauma, PTSD, and drinking in "emerging adults" (ages 21-30 years), in spite of this age group being at highest risk of developing subsequent drinking problems. The proposed clinical laboratory project will use a three group design. The target population will have no trauma exposure [Control group], trauma exposure without PTSD [TE group], and trauma exposure with PTSD [PTSD group]. The type of traumatic event exposure history included will be limited to interpersonal trauma. This project will use a well-established clinical laboratory paradigm of stress induction employed during the current Center funding period, the Trier Social Stress Test (TSST), to investigate the role of a history of exposure to trauma on reactivity to the TSST and on stress-induced voluntary drinking. Subjects will not meet diagnostic criteria for alcohol dependence. Half of each group will receive the TSST and the other half will be randomized to the no stress condition. Using subjective as well as biological indices of stress, the first specific aim examines the effect of trauma history on stress reactivity, using subjective, neuroendocrine, and physiological measures of stress. The second specific aim will examine the effect of trauma history on subsequent drinking behavior and subjective response to alcohol using established procedures in a clinical laboratory paradigm. Exploratory analyses will also be conducted to examine the correlation between trauma history group and subjective response to stress, and trauma history group and drinking. Two additional exploratory analyses will evaluate the effect of the personality trait of distress tolerance (high and low), and the effect of carrying the 'S' or the rare 'L{G}' allele of the 5-HTTLPR polymorphism on the stress response and on voluntary drinking following stress induction. This study will advance our understanding of the relationship between a history of interpersonal trauma, stress, and drinking. The ultimate goal of this line of research is to identify "at risk" groups early in their drinking careers, before unhealthy drinking practices and/or dependence develop. This information has the potential to inform prevention and intervention alcohol research.

一生中任何时候经历过创伤性事件的人，尤其是患有创伤后应激障碍 (PTSD) 的人，酗酒问题的发生率较高。然而，人们对“新兴成年人”（21-30 岁）的创伤、创伤后应激障碍和饮酒之间的关系知之甚少，尽管这个年龄段出现后续饮酒问题的风险最高。拟议的临床实验室项目将采用三组设计。目标人群将没有外伤暴露[对照组]、外伤暴露无PTSD[TE组]、外伤暴露伴PTSD[PTSD组]。这所包括的创伤事件暴露史类型将仅限于人际创伤。该项目将使用在当前中心资助期间采用的成熟的压力诱导临床实验室范式，即特里尔社会压力测试（TSST），以调查创伤暴露史对 TSST 反应和压力的作用-诱发自愿饮酒。受试者不符合酒精依赖的诊断标准。每组的一半将接受 TSST，另一半将被随机分配到无压力条件。第一个具体目标利用主观和生物压力指标，利用主观、神经内分泌和生理压力测量方法，检查创伤史对压力反应性的影响。第二个具体目标将使用临床实验室范例中的既定程序来检查创伤史对随后饮酒行为和对酒精的主观反应的影响。还将进行探索性分析，以检查创伤史组与对压力的主观反应以及创伤史组与饮酒之间的相关性。另外两项探索性分析将评估应激耐受性人格特征（高和低）的影响，以及携带“S”或 5-HTTLPR 多态性的罕见“L{G}”等位基因对应激反应的影响以及压力诱导后的自愿饮酒。这项研究将增进我们对人际创伤史、压力和饮酒之间关系的理解。这一系列研究的最终目标是在不健康的饮酒习惯和/或依赖性形成之前，在饮酒生涯的早期识别“高危”群体。这些信息有可能为预防和干预酒精研究提供信息。