TRF2 INTERACTING PROTEINS

TRF2 相互作用蛋白

• 批准号: 8365840
• 负责人: Eros Lazzerini Denchi
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365840
• 关键词: Binding; Biology; Chromosomes; Data; Essential Genes; Funding; Fungal Genome; Grant; National Center for Research Resources; Principal Investigator; Protein Binding; Proteins; Recruitment Activity; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; telomere

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. TRF2 is an essential gene that localizes to telomeres and is required for chromosome end protection. TRF2 binds to double stranded telomeric repeats (TTAGGG) and serves as an anchoring protein required to recruit additional factors. Recent data suggest that over 200 proteins are bound at telomeres.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 TRF2是一个本地化为端粒的必不可少的基因，是染色体终端保护所必需的。 TRF2结合了双链端粒重复序列（TTAGGG），并用作募集其他因素所需的锚定蛋白。最近的数据表明，超过200种蛋白质在端粒处结合。