TRANSDISCIPLINARY IMAGING GENETICS CENTER (RMI)

跨学科影像遗传学中心 (RMI)

• 批准号: 8363436
• 负责人: STEVEN G POTKIN
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363436
• 关键词: Adverse effects; Alleles; Antipsychotic Agents; Area; Brain; Brain imaging; Charge; Clinical; Collaborations; Complement; Complex; DRD1 gene; Data; Development; Diagnosis; Discipline; Disease; Environment; Essential Genes; Functional disorder; Funding; Genetic; Genomics; Goals; Grant; Health; Human Genome Project; Image; Image Analysis; Imaging Techniques; Individual Differences; Inherited; International; Knowledge; Mental disorders; Methods; Modeling; Motor; National Center for Research Resources; Positioning Attribute; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Risk; Solutions; Source; Statistical Methods; Tardive Dyskinesia; United States National Institutes of Health; Universities; Work; brain metabolism; computational anatomy; cost; experience; field study; improved; mental development; novel; response; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overriding goal of the proposed Transdisciplinary Imaging Genetics Center, an exploratory center, is to enhance our understanding of brain function in health and disease, through facilitation of development of a new discipline, referred to as imaging genetics. The Center does this by assembling an interdisciplinary team of experts from U.C. Irvine and the University of Toronto with experience in genomics, imaging analysis, statistical methods, and complementary areas viewed as key to this goal. These experts, complemented by the Center's consultants and External Advisory Board, have developed novel methods in their respective fields. The major focus of this project is to develop methods for combining imaging and genomics. It is clear that mental illness involves brain dysfunction that can be visualized with advanced brain imaging techniques. Mental illness as well as normal brain function also has a hereditary component; therefore, it is essential that the genes related to aspects of brain development, mental function and dysfunction, be considered. The integration of the imaging data with the rich genetic data resulting from the human genome project will enhance our understanding of brain function and mental illness. The value of this integration is illustrated in our initial studies that demonstrated an association between brain metabolism, clinical response and DRD1 alleles (Potkin at al, 2003), and between brain metabolism, risk of tardive dyskinesia, a motor side-effect on antipsychotic treatment, and DRD3 alleles (Potkin et al 2003b, Basile et al, 2002). The Center proposes the facilitation of an ongoing dialogue among the various fields involved by sponsoring annual international symposia and the development and implementation of a roadmap or work plan for this emerging discipline. The work plan for the Center will be guided by a transdiscipllnary collaboration between the Center investigators, their Steering Committee, the Center consultants, and the External Advisory Board. The Steering Committee and External Advisory Board are also charged with evaluating the Center's research progress and suggesting alternative solutions, as well as guiding the overall development of the Center. If the aims of the Center are achieved, the emerging field of genetic imaging will be positioned to enhance understanding of the biologically complex problem of mental illness, individual differences, and the interplay between genetics, environment, and brain function. Study of these fields individually has provided important revelations regarding brain dysfunction. Their integration and interaction, however, will provide new knowledge that would not be otherwise available. These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 探索性中心提议的跨学科成像遗传学中心的压倒性目标是通过促进新学科的发展（称为成像遗传学）来增强我们对健康和疾病中大脑功能的理解。该中心通过组建来自U.C.的专家跨学科团队来实现这一目标。欧文（Irvine）和多伦多大学（University of Toronto）具有基因组学，成像分析，统计方法和互补领域的经验，被视为这一目标的关键。这些专家在中心的顾问和外部顾问委员会中得到补充，在各自领域开发了新颖的方法。该项目的主要重点是开发组合成像和基因组学的方法。显然，精神疾病涉及大脑功能障碍，可以通过先进的大脑成像技术可视化。精神疾病以及正常的大脑功能也具有遗传成分。因此，必须考虑与大脑发育，心理功能和功能障碍有关的基因。成像数据与人类基因组项目产生的丰富遗传数据的整合将增强我们对脑功能和精神疾病的理解。在我们的初步研究中说明了这种整合的价值，该研究表明，脑代谢，临床反应与DRD1等位基因（AL，2003年的Potkin）与脑代谢之间存在关联，迟发性发育不良的风险，抗精神病药物治疗的运动副作用，抗精神病药物治疗和DRD3等位基因（Potkin et alles et alles et al et al 2003b，2003b，basile et al al al and and 2002）。该中心提议在赞助年度国际研讨会以及该新兴纪律的路线图或工作计划的制定和实施方面涉及的各个领域之间进行持续的对话。该中心的工作计划将由中心调查员，其指导委员会，中心顾问和外部顾问委员会之间的跨学科合作指导。指导委员会和外部顾问委员会还负责评估中心的研究进度并提出替代解决方案，并指导中心的整体发展。如果实现了中心的目标，则将定位遗传成像的新兴领域，以增强对精神疾病，个体差异以及遗传学，环境和大脑功能之间的生物学复杂问题的理解。对这些领域的研究分别提供了有关脑功能障碍的重要启示。但是，他们的集成和互动将提供新知识，而这些知识将无法获得。如果没有一个专注于单个综合主题的统一中心，就无法实现这些目标。该中心产生的新知识具有改善精神疾病诊断和治疗的巨大希望。