RF SAFETY STUDIES IN PORCINE MODELS

猪模型中的射频安全研究

• 批准号: 8362821
• 负责人: John T Vaughan
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362821
• 关键词: Anesthesia procedures; Animals; Authorization documentation; Brain; Calibration; Drops; Family suidae; Funding; Grant; Head; Heating; Hour; Human; Magnetic Resonance Imaging; Maps; Measures; Modeling; NMR Spectroscopy; National Center for Research Resources; Physiologic pulse; Principal Investigator; Research; Research Infrastructure; Resources; Source; System; Temperature; Thermometry; United States National Institutes of Health; Work; cost; safety study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. RF heating will be measured using our 3T MR system and fluoroptic thermometry in human sized swine (60-80 kg). Continuous wave/Pulsed RF will be delivered using a 3T, 7T, 9.4T, or 11.74 T head coil. Temperatures will be measured using a GRE sequence, Shalom's T1r and T2r sequences, and a 3T head coil, and fluoroptic probes. To measure temperatures using MR, temperature calibration will be done using unheated, anesthetized pigs. Anesthesia causes animal to drop their temperatures linearly and uniformly everywhere in the brain. Typically speaking, the core temperature of a 60-80 kg pig drops from 38 to 32 degree C in 10-12 hours. Temperatures in the animal brain will be measured using fluoroptic probes for this duration. PRF/T1r/T2r will be measured over the duration and their slope maps will be correlated to the linearly decreasing fluoroptic temperatures. The developed slope maps will be used to estimate temperatures in RF heated pigs. Permission will be sought from the Siemens before any RF heating work will be commenced on the 3T.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 将使用我们的 3T MR 系统和荧光测温法对人类大小的猪（60-80 公斤）测量射频加热。连续波/脉冲射频将使用 3T、7T、9.4T 或 11.74T 头部线圈传送。将使用 GRE 序列、Shalom 的 T1r 和 T2r 序列、3T 头部线圈和荧光探针测量温度。 为了使用 MR 测量温度，将使用未加热、麻醉的猪进行温度校准。麻醉导致动物大脑各处的温度线性且均匀地下降。一般来说，60-80公斤重的猪的核心温度在10-12小时内从38摄氏度降至32摄氏度。在此期间将使用荧光探针测量动物大脑的温度。将在整个持续时间内测量 PRF/T1r/T2r，它们的斜率图将与线性降低的荧光温度相关。开发的斜率图将用于估计射频加热猪的温度。在 3T 上开始任何射频加热工作之前，将征求西门子的许可。