COBRE: LSU: COMPUTATIONAL NEUROSCIENCE CORE FACILITY

COBRE：LSU：计算神经科学核心设施

• 批准号: 8359601
• 负责人: Carmen Castro Canavier
• 金额: $ 4.81万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359601
• 关键词: Biology; Cells; Centers of Research Excellence; Complex; Computer Simulation; Core Facility; Coupled; Equation; Funding; Grant; Louisiana; Mentors; National Center for Research Resources; Neurosciences; Participant; Principal Investigator; Process; Research; Research Infrastructure; Resources; Signal Transduction; Source; System; United States National Institutes of Health; complex biological systems; computational neuroscience; cost; design; programs; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Complex biological systems within a single cell are governed by complex coupled nonlinear dynamical processes. Such systems respon to perturbations in nonintuitive ways and can be best understood by synthesizing a coherent description of the signaling system as a set of coupled nonlinear ordinary differential equations that can be solved numerically. Such a system can be used to synergistically design experiments to confirm and extend our theoretical understanding of the biology. This core module consists of a dedicated server that can accessed by COBRE participants for use in computer modeling to help them better predict the results of there experiments.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 单细胞内的复杂生物系统受到复杂耦合的非线性动力学过程的控制。此类系统以非直观的方式响应扰动，并且可以通过将信号系统的连贯描述综合为一组可以数值求解的耦合非线性常微分方程来最好地理解。这样的系统可用于协同设计实验，以确认和扩展我们对生物学的理论理解。该核心模块由一个专用服务器组成，COBRE 参与者可以访问该服务器以用于计算机建模，以帮助他们更好地预测实验结果。