NKT CELLS AS MODULATORS OF IMMUNE ACTIVATION IN SOOTY MANGABEYS

NKT 细胞作为乌白眉猴免疫激活的调节剂

• 批准号: 8357946
• 负责人: Amitinder Kaur
• 金额: $ 19.39万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357946
• 关键词: Acquired Immunodeficiency Syndrome; Cercocebus atys; Funding; Grant; HIV; Immune system; Infection; Interleukin-10; Ligands; National Center for Research Resources; New England; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Source; T-Lymphocyte; T-Lymphocyte Subsets; United States National Institutes of Health; base; cost; cytokine; immune activation; killer T cell; Acquired Immunodeficiency Syndrome; Cercocebus atys; Funding; Grant; HIV; Immune system; Infection; Interleukin-10; Ligands; National Center for Research Resources; New England; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Source; T-Lymphocyte; T-Lymphocyte Subsets; United States National Institutes of Health; base; cost; cytokine; immune activation; killer T cell

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Natural Killer T (NKT) lymphocytes are a unique subset of T lymphocytes that have an invariant TCR Valpha chain and recognize ligands presented by the nonpolymorphic CD1d molecule. Functionally, CD1d-reactive NKT cells can secrete large amounts of both Th-1 and Th-2 type cytokines, including IL-10, and are early effectors of the innate immune system. By virtue of the diverse cytokines that they secrete, NKT cells may play a role in modulating immune activation in HIV and SIV infection. Sooty mangabeys are a natural host of SIV that do not progress to AIDS. A key differentiating feature of SIV infection in its natural host is the absence of aberrant immune activation. In this project we are investigating whether NKT cells are responsible for the lack of aberrant immune activation in naturally SIV-infected sooty mangabeys.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 天然杀伤剂T（NKT）淋巴细胞是具有不变TCR valpha链的T淋巴细胞的独特子集，并识别由非差异性CD1D分子呈现的配体。 在功能上，CD1D反应性NKT细胞可以分泌大量的TH-1和TH-2型细胞因子，包括IL-10，并且是先天免疫系统的早期效应子。 由于它们分泌的各种细胞因子，NKT细胞可能在调节HIV和SIV感染中的免疫激活中发挥作用。 烟灰芒果是天然的SIV寄主，不会发展为艾滋病。 SIV感染在其自然宿主中的关键区分特征是没有异常的免疫激活。 在这个项目中，我们正在研究NKT细胞是否负责自然感染的SIV感染的烟草芒果中缺乏异常的免疫激活。