EXCERCISE LIPID BW

运动脂质 BW

• 批准号: 7951439
• 负责人: Teletia Renee Taylor
• 金额: $ 20.11万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951439
• 关键词: Aerobic Exercise; Affect; African; African American; Age; Cancer Cell Growth; Caucasians; Caucasoid Race; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data Collection; Diet; Exercise; Fatty acid glycerol esters; Funding; Grant; IGF1 gene; Incidence; Institution; Insulin; Insulin-Like Growth Factor I; Intervention; Life Style; Lipids; Malignant neoplasm of prostate; PSA level; Prostate-Specific Antigen; Randomized; Recruitment Activity; Research; Research Personnel; Resources; Risk; SHBG gene; Serum; Sex Hormone-Binding Globulin; Source; Testosterone; United States National Institutes of Health; Universities; human IGFBP2 protein; men; sedentary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: African-American men have the highest incidence of prostate cancer in the world. The incidence of prostate cancer in African-American men is 59% greater than in Caucasian men. The exact cause for the increased incidence of prostate cancer in African-American is unknown. However, a diet high in fat and/or a sedentary lifestyle may predispose African-African men to prostate cancer by affecting levels of serum factors that potentate the growth of the cancer cells such as free testosterone, sex hormone-binding globulin (SHBG), insulin, insulin-like growth factor-1 (IGF1), prostate-specific antigen (PSA), and insulin-like growth factor binding proteins- 2 and 3. Aims and Objectives: 1. To recruit 40 African-American men between the ages of 40 and 70 who are at increased risk for developing prostate cancer and randomize them into an exercise intervention or control group. 2. To examine the effect of 12 days of aerobic exercise over 4 weeks on PSA levels in African-American men who have PSA levels under 4.0 ng/ml. 3. To examine the effect of 12 days of aerobic exercise on free and total testosterone, insulin, IGF1, and SHBG levels in African-American men. Progress to date: Data collection still in progress. Continuation of grant has been requested.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 背景： 非洲裔美国男性前列腺癌的发病率是世界上最高的。 非裔美国男性前列腺癌的发病率比白人男性高 59%。 非裔美国人前列腺癌发病率增加的确切原因尚不清楚。 然而，高脂肪饮食和/或久坐的生活方式可能会影响促进癌细胞生长的血清因子的水平，例如游离睾酮、性激素结合球蛋白 (SHBG)、胰岛素、胰岛素样生长因子-1 (IGF1)、前列腺特异性抗原 (PSA) 和胰岛素样生长因子结合蛋白 - 2 和 3。 目的和目标： 1. 招募 40 名年龄在 40 岁至 70 岁之间、患前列腺癌风险较高的非裔美国男性，并将他们随机分为运动干预组或对照组。 2. 研究 4 周内 12 天的有氧运动对 PSA 水平低于 4.0 ng/ml 的非裔美国男性 PSA 水平的影响。 3. 研究 12 天有氧运动对非裔美国男性游离睾酮和总睾酮、胰岛素、IGF1 和 SHBG 水平的影响。 迄今为止的进展：数据收集仍在进行中。已请求继续拨款。