Suppression of Negative Affect Indexed by the Late Positive Potential in Smokers

以吸烟者晚期积极潜力为指标的消极影响的抑制

基本信息

批准号：
8304199
负责人：
Jennifer Anne Minnix
金额：
$ 24.41万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8304199
关键词：
Abstinence Acute Affect Affective Aftercare Area Award Behavioral Clinical Clinical Practice Guideline Cognitive Cognitive Therapy Counseling County Cues Data Depressed mood Electrodes Emotional Emotions Evaluation Failure Female Fostering Future Grant Hour Human body Individual Individual Differences Instruction Investigation Knowledge Laboratories Literature Measures Mentors Methods Nicotine Nicotine Dependence Nicotine Withdrawal Participant Patient Self-Report Phase Population Population Study Process Psychophysiology Recruitment Activity Regulation Relapse Relative (related person)Research Research Design Research Personnel Resources Smoke Smoker Smoking Stimulus Techniques Time Tobacco Use Cessation Training Treatment outcome Withdrawal Withholding Treatment analog deprivation design emotional experience emotional reaction emotional stimulus falls follow-up indexing nicotine patch nicotine replacement novel research study response smoking cessation success therapy design treatment as usual

项目摘要

The focus of this proposal is to expantd upon the research conducted in the K99 project in which I evaluated the effects of nicotine withdrawal on ERP activity associated with a cognitive reappraisal task used to suppress or enhance emotional activation. This project will take the next step and will evaluate smokers who want to quit smoking, relating their LPP responses to the experimental tasks to treatment outcome. This study will apply the cognitive reappraisal paradigm to a group of smokers undergoing tobacco cessation treatment that follows the clinical practice guidelines for usual care. Specifically, 60 (50% female) smokers with the desire to quit will be recruited from the general Harris county population and asked to attend an orientation session, 2 laboratory sessions (pre-quit and post-quit) and follow-up counseling and abstinence assessment sessions. During the first laboratory session (pre-quit), smokers will complete a laboratory cognitive reappraisal task in which they are asked to enhance or suppress their emotional reaction to pictoral stimuli. Subsequently, they will also begin a course of usual care treatment, involving behavioral counseling and nicotine replacement therapy. Approximately 24 hours after their quit date, smokers will again be asked to attend a laboratory session (post-quit) where they will repeat the cognitive reappraisal task and receive the last 4 weeks worth of nicotine patches. Smokers' abstinence will be biochemically verified on the quit date, and subsequent assessments including the end of treatment (EOT) and 3 months post-quit. This project provides an opportunity to evaluate the predictive power of individual differences in LPP changes following suppression and enhancement of emotional cues relative to a control, both prior to and immediately following quit day, on the participant's ability to stay quit at the end of treatment and again 3 months later. This study is entirely novel in the nicotine dependence and tobacco cessation literature, though the paradigm has been validated using multiple methods.

该提案的重点是指出我评估的K99项目中进行的研究尼古丁提取对与认知重新评估任务相关的ERP活动的影响抑制或增强情绪激活。该项目将采取下一步，并评估吸烟者想要戒烟，将其LPP对实验任务的反应与治疗结果有关。这研究将应用认知重新评估范式应用于一群正在戒烟的吸烟者遵循常规护理的临床实践指南的治疗方法。具体而言，有60名（50％的女性）吸烟者希望退出的愿望将从哈里斯县将军招募，并要求参加定向课程，2次实验室会议（提问前和询问后）以及后续咨询和禁欲评估会议。在第一次实验室会议（预先提示）中，吸烟者将完成一个实验室认知重新评估任务，要求他们增强或抑制他们对Pictoral的情感反应刺激。随后，他们还将开始通常的护理治疗方法，涉及行为咨询和尼古丁替代疗法。退出日期大约24小时后，将再次询问吸烟者参加实验室会议（后），他们将重复认知重新分配任务并接受最近4周的尼古丁补丁。吸烟者的禁欲将在戒烟上进行生化验证日期和随后的评估，包括治疗终结（EOT）和QIT后3个月。这项目提供了评估LPP变化中个体差异的预测能力的机会在抑制和增强情绪线索相对于对照的抑制和增强，无论是在之前还是立即退出一天之后，参与者在治疗结束时以及3个月后再次戒烟的能力。这项研究在尼古丁依赖性和烟草停止文献中完全是新颖的，尽管范式已使用多种方法验证。