SENSITIVITY OF DIFFUSION TENSOR IMAGING (DTI) IN MILD TO MODERATEL PEDIATRIC TRA

弥散张量成像 (DTI) 在轻至中度儿科手术中的敏感性

• 批准号: 7951688
• 负责人: JEFFREY ROBERT WOZNIAK
• 金额: $ 0.73万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951688
• 关键词: Adolescent; Age; Brain; Child; Clinical Research; Closed head injuries; Computer Retrieval of Information on Scientific Projects Database; Craniocerebral Trauma; Diffusion Magnetic Resonance Imaging; Funding; Grant; Institution; Magnetic Resonance Imaging; Neurocognitive; Population; Recording of previous events; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Youth; imaging modality; patient population; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the structural and neurocognitive brain differences between children/adolescents (ages 10-17) with a history of mild to moderate closed head injury and healty controls. This project seeks to demonstrate that microstructural white matter integrity may be compromised in youth who have suffered mild to moderate head injury and that these white matter abnormalities may be associated with impaired neurocognitive functioning. We propose to investigate white matter abnormalities in this population by using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) method that has not previously been used to explore this patient population.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是调查有轻度至中度闭合性头部损伤史和健康对照的儿童/青少年（10-17 岁）之间的结构和神经认知大脑差异。该项目旨在证明，遭受轻度至中度头部损伤的青少年的微结构白质完整性可能会受到损害，并且这些白质异常可能与神经认知功能受损有关。我们建议通过使用弥散张量成像（DTI）来研究该人群中的白质异常，这是一种磁共振成像（MRI）方法，以前从未用于探索该患者人群。