RENAL CYTOCHROME P450 EPOXYGENASE IN DIABETIC METABOLIC SYNDROME

糖尿病代谢综合征中的肾细胞色素 P450 环氧合酶

• 批准号: 8357157
• 负责人: Xueying Zhao
• 金额: $ 9.49万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357157
• 关键词: Biomedical Research; Cytochrome P450; Development; Diabetic Nephropathy; Epithelial; Functional disorder; Funding; Goals; Grant; Injury; Kidney; Metabolic syndrome; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; diabetic; kidney vascular structure; medical schools; multidisciplinary; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Specific Aims The overall goal of this project remains the same and is to elucidate the regulatory mechanism(s) and functional consequences of cytochorme P450 (CYP) epoxygenase metabolites (EETs) in the development and progression of vascular and renal dysfunction related to diabetic metabolic syndrome. Experiments performed over the project period have resulted in significant progress on the three Specific Aims. In addition, we have expanded our recent studies to determine glomerular epithelial injury in progressive diabetic nephropathy.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 具体目标 该项目的总体目标保持不变，并阐明了在与糖尿病代谢综合征相关的血管和肾功能障碍的发育和进展中，细胞牙齿P450（CYP）环氧酶代谢物（EET）的调节机制和功能后果。在整个项目期间进行的实验在三个特定目标上取得了重大进展。此外，我们扩大了最近的研究，以确定进行性糖尿病性肾病的肾小球上皮损伤。