Faculty Recruitment and Core Resource Development in Stem Cell Biology

干细胞生物学教师招聘和核心资源开发

• 批准号: 7860752
• 负责人: CECILIA W. LO
• 金额: $ 66.05万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860752
• 关键词: Acute; Advisory Committees; Area; Arts; Basic Science; Biomedical Research; Cardiovascular system; Clinical; Clinical Trials; Communities; Core Facility; Development; Development Plans; Developmental Biology; Disease; Doctor of Philosophy; Ensure; Equilibrium; Ethics; Faculty; Funding; Future; Goals; Health Services Research; Hematological Disease; Housing; Human Resources; Innovative Therapy; Interview; Investigation; Laboratories; Leadership; Lung; Medical center; Mentors; Patients; Pediatric Hospitals; Policies; Positioning Attribute; Production; Productivity; Publications; Qualifying; Recommendation; Recovery; Recruitment Activity; Research; Research Activity; Research Ethics Committees; Research Infrastructure; Research Personnel; Resource Development; Resource Sharing; Resources; Running; Scientist; Services; Stem Cell Development; Stem Cell Research; Stem cells; Structure; Supervision; Time; Training; Transgenic Organisms; Translational Research; Universities; Work; base; experience; human stem cells; induced pluripotent stem cell; interdisciplinary approach; interest; medical schools; meetings; professor; programs; ranpirnase; research and development; research facility; response; stem; stem cell biology; stem cell technology; translational medicine

DESCRIPTION (provided by applicant): The overarching goal of this P30 application is to enhance research capacity in the understanding and treatment of cardiovascular, pulmonary, and blood diseases through the development of stem cell resources. To accomplish this, we propose to recruit and hire Dr. In-Hyun Park as tenure tract faculty in the newly formed Department of Developmental Biology, in direct response to RFA-OD-09-005 "Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers" (P30). Dr. Park possesses a wealth of experience in stem cell research and has generated some of the first induced pluripotent stem (iPS) cells from patients with a wide range of diseases. The successful recruitment of Dr. Park, and later, other highly qualified tenure tract faculty will be augmented by the development of a new Stem Cell Core. Hence, the three specific aims of this P30 proposal comprises: 1. Recruit new tenure track faculty in the field of stem cell biology, 2. Create a Stem Cell Core to support and enhance stem cell research via a university-wide shared resource for the production and distribution of stem cells, and 3. Create through the Stem Cell Core, a pipeline for personnel training and development of new stem cell technologies to enhance stem cell research. Dr. Park will serve as the Director of the Stem Cell Core, providing scientific oversight for the Core. He will be assisted by an assistant director who will manage the day to day activities of the Core. An advisory committee comprised of faculty from different departments/divisions of the University will be assembled to assist with establishing policies for running the core. This will include guidance on ethics issues related to human stem cell research. In addition, an overlapping mentoring committee will be assembled to assist Dr. Park with a faculty development plan and to provide guidance on balancing and prioritizing Dr. Park's research needs with other demands of the Core. This administrative and leadership structure will enhance the research productivity of the new faculty recruit, and at the same time, facilitate the work of other faculty interested in stem cell research. Overall, the recruitment of Dr. Park, the establishment of this Stem Cell Core, and the creation of the Dept of Developmental Biology reflect the University's multidisciplinary approach to biomedical research, and fills a gap that exists with respect to stem cell resources. Placement of the Stem Cell Core in the new Department at the Ranges Research Center will encourage the integration of basic science investigation into developmental mechanisms with clinical investigation into disease mechanisms. Together, the successful implementation of these endeavors, will promote interdisciplinary stem cell based translational research and the development of new, innovative therapies.

描述（由申请人提供）：该 P30 申请的总体目标是通过开发干细胞资源来增强对心血管、肺和血液疾病的理解和治疗的研究能力。为了实现这一目标，我们建议招募和聘用 In-Hyun Park 博士作为新成立的发育生物学系的终身教职人员，直接回应 RFA-OD-09-005“恢复法案有限竞争：支持新教员招聘”通过生物医学研究核心中心增强研究资源”（P30）。 Park 博士在干细胞研究方面拥有丰富的经验，并从患有多种疾病的患者身上培育出了一些首批诱导多能干 (iPS) 细胞。新干细胞核心的开发将增强 Park 博士以及其他高素质终身教授的成功招募。因此，该 P30 提案的三个具体目标包括： 1. 招募干细胞生物学领域的新终身教职人员， 2. 创建干细胞核心，通过全校共享资源支持和加强干细胞研究干细胞的生产和分销，以及 3. 通过干细胞核心创建人员培训和开发新干细胞技术的管道，以加强干细胞研究。 Park 博士将担任干细胞核心的主任，为该核心提供科学监督。他将得到一名助理主任的协助，负责管理核心的日常活动。将组建一个由大学不同院系/部门的教师组成的咨询委员会，以协助制定核心运行政策。这将包括与人类干细胞研究相关的伦理问题的指导。此外，还将组建一个重叠的指导委员会，协助 Park 博士制定教师发展计划，并为平衡和优先考虑 Park 博士的研究需求与核心的其他需求提供指导。这种行政和领导结构将提高新聘教师的研究生产力，同时促进其他对干细胞研究感兴趣的教师的工作。 总体而言，Park博士的招募、干细胞核心的建立以及发育生物学系的创建反映了大学在生物医学研究方面的多学科方法，并填补了干细胞资源方面存在的空白。将干细胞核心放置在 Ranges 研究中心的新部门将鼓励将基础科学研究与发育机制与疾病机制的临床研究相结合。这些努力的成功实施将共同促进基于干细胞的跨学科转化研究和新的创新疗法的开发。