Examining the Effects of High Protein Diet on Outcomes in Heart Failure Patients
检查高蛋白饮食对心力衰竭患者预后的影响
基本信息
- 批准号:8320481
- 负责人:
- 金额:$ 45.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-17 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcademyAddressAdherenceAdultAdvisory CommitteesAffectAgeAmericanAmerican Heart AssociationAmericasAngiotensin-Converting Enzyme InhibitorsAxonBiochemicalBiological PreservationBlood GlucoseBlood PressureBody CompositionBody WeightBody Weight decreasedBody fatBody mass indexCachexiaCaliberCarbohydratesCardiacCardiologyCardiomyopathiesCardiopulmonaryCardiovascular DiseasesCessation of lifeChestCholesterolChronicClinicalClinical TrialsCollaborationsCongestive Heart FailureCounselingDataData AnalysesDevelopmentDiabetes MellitusDiagnosisDietDiet ModificationDiet and NutritionDietary InterventionDietary PracticesDiseaseDisease ProgressionEffectivenessEmotionalEtiologyEuropeanEvaluationExerciseExercise stress testExhibitsFailureFamilyFastingFat-Restricted DietFatty acid glycerol estersFriendsGeneral PopulationGlycosylated hemoglobin AGoalsGrantGuidelinesHealthHealth ProfessionalHeartHeart RateHeart TransplantationHeart failureHeart-Lung TransplantationHigh Density Lipoprotein CholesterolHollyHomeostasisHospitalizationHypertriglyceridemiaImpairmentIndividualInformation Resources ManagementInsulin ResistanceIntakeInternationalInterventionInvestigationJournalsLDL Cholesterol LipoproteinsLeftLegalLipidsLong-Term EffectsMacronutrients NutritionMaintenanceMalnutritionMarshalMeasurementMeasuresMetabolicMetabolic syndromeMetabolismMethodsModalityModelingMonitorMorbidity - disease rateMuscleNIH Program AnnouncementsNatureNew YorkNon-Insulin-Dependent Diabetes MellitusNursesNutritionalOatsObesityObservational StudyOutcomeOverweightParticipantPatient Self-ReportPatientsPeroxisome Proliferator-Activated ReceptorsPharmaceutical PreparationsPhysical activityPhysiciansPlasmaPractice GuidelinesPrevalencePreventionProteinsQuality of lifeRandomizedRandomized Clinical TrialsRecommendationRecoveryReportingResearch PersonnelResearch SupportRiskRisk FactorsRisk MarkerRoleScienceServicesSocietiesSpecific qualifier valueStrokeStructureSubgroupSymptomsSystolic heart failureTestingTimeTransplantationTriad Acrylic ResinTwo-Dimensional Doppler EchocardiographyUnited StatesUnited States National Institutes of HealthUpdateVentricularVeteransWalkingWeightWeight maintenance regimenWomanWritingabstractingarmbiobehaviorblood lipidcardiovascular risk factorcollegecommunity settingcompliance behaviorcost effectivenessdesigndiabetic patientdietary restrictiondisabilitydosagefollow-upfunctional disabilityfunctional statusglycemic controlheart rhythmhemodynamicsimmune functionimprovedindexinginsulin sensitivityinterdisciplinary approachknowledge basemalemenmortalitynutritionoutcome forecastpost interventionprognosticprogramsprospectiverandomized trialreceptorresponsesuccesstooltreatment effecttrendwaist circumferencewastingweight loss interventionweight maintenanceworking group
项目摘要
Heart failure (HF), obesity, and diabetes mellitus (DM) often co-exist and are associated with the development and progression of cardiovascular disease, functional disability, increased symptoms, and diminished quality of life (QOL). Nutritional management of HF, obesity, and DM is poorly understood and little guidance is available regarding dietary approaches for these patients. The proposed study is designed to test the effects of a high protein (HP) diet vs. a standard protein (SP) diet on adiposity, cardiac structure, functional status, lipid profiles, glycemic control, insulin resistance, and QOL in 90 patients with HF, New York Heart Association class II and III, body mass index (BMI) ¿ 30 kg/m2, and DM. A prospective, two-group, randomized design will be used to test the study hypotheses. Participants will be randomized to either a HP or SP diet. The prescribed HP diet consists of 30% of energy from protein (~110 g/day), 40% of energy from carbohydrate (CHO; ~150 g/day) and 30% from fat (~50 g/day), while the SP diet consists of 15% of energy from protein (~55 g/day), 55% of energy from CHO (~200 g/day) and 30% from fat (~50 g/day). Patients in the 2 study arms will participate in an intensive 12-week supervised weight loss intervention during which they will receive personalized nutritional counseling and support at baseline and asked to return at 1, 2, 4, 8, and 12 weeks. Patients will be encouraged to engage in 20-30 minutes of physical activity, such as walking, three to five days per week and gradually increase to 30-60 minutes daily to promote energy deficit and facilitate weight loss. After the 3-month dietary intervention, participants will be instructed to continue the same dietary pattern followed during the previous 12 weeks of the study (maintenance). They will be seen every 3 months for one year (weeks 24, 36, 48, and 60) to monitor weight maintenance. Weight, BMI, waist circumference, dual-energy x-ray absorptiometry, 2D and Doppler echocardiography, cardiopulmonary exercise stress testing, six minute walk test, biochemical analyses (plasma lipid profiles, fasting blood sugar, and homeostasis model assessment), and self-reported measures of QOL will be completed at 3 measurement periods: baseline, immediately after the 3-month dietary intervention (12-weeks), and one year post intervention (60 weeks). The overall goal of the study is to test the hypothesis that a HP diet will result in significantly greater reductions in adiposity and greater improvements in cardiac structure, functional status, lipid profiles, glycemic control and insulin resistance, and QOL following the 3-month intervention and that these changes will be maintained over time. Mixed models will be used to analyze the data. Data from the proposed study will provide researchers and clinicians with a better understanding of the biobehavioral underpinnings associated with obesity, HP diets, and weight loss outcomes. This information will provide evidence for rational recommendations for weight loss modalities that can be integrated in HF management and treatment guidelines.
心力衰竭(HF),肥胖和糖尿病(DM)经常共存,并与心血管疾病,功能障碍,症状增加和生活质量降低(QOL)的发育和发展有关。 HF,肥胖和DM的营养管理知之甚少,对于这些患者的饮食方法,几乎没有指导。拟议的研究旨在测试高蛋白(HP)饮食与标准蛋白(SP)饮食对肥胖,心脏结构,功能状态,脂质谱,糖症控制,胰岛素抵抗和QOL的影响,在90名HF患者中,纽约心脏II和III级和III,III和III,体重指数(BMI)(BMI)(BMI)€30 KG/M2和DM和DM和DM。前瞻性,两组随机设计将用于检验研究假设。参与者将被随机分为HP或SP饮食。规定的HP饮食由蛋白质(约110 g/day)的30%能量,碳氢化物的40%(CHO; 〜150 g/day)和脂肪(〜50 g/day)的30%组成,而SP饮食由蛋白质(〜55 g/day)的15%的能量组成,55%的能量,55%的能量(量为5 g/day)和30%(〜200 g/day)和30%(〜50%)(〜50%)(〜50%)(〜50%)。 2个研究臂的患者将参加一项为期12周的监督减肥干预措施,在此期间他们将在基线上获得个性化的营养咨询和支持,并要求在1、2、4、8和12周返回。将鼓励患者参加20-30分钟的体育锻炼,例如步行,每周三到五天,并逐渐增加至30-60分钟,以促进能量防御和支持减肥。经过3个月的饮食干预后,将指示参与者在研究的前12周(维护)继续遵循相同的饮食模式。每3个月(24、36、48和60周)将每3个月看到它们,以监视体重维持。重量,BMI,腰围,双能X射线绝对能力学,2D和多普勒超声心动图,心肺运动压力测试,六分钟步行测试,生物化学分析,血浆脂质分析(血浆脂质概况(血浆脂质)概况,固定量,以及固定量的衡量标准,以及固定量的量表:三个月的饮食干预(12周)和干预后一年(60周)。该研究的总体目的是检验以下假设:HP饮食将导致肥胖度的降低和心脏结构,功能状态,脂质谱,血糖控制和胰岛素抵抗以及3个月干预后的QOL的更大改善,并随着时间的推移而维持这些变化。混合模型将用于分析数据。拟议研究的数据将为研究人员和临床医生提供更好地了解与肥胖,HP饮食和体重减轻结果相关的生物行为基础。该信息将为可以集成在HF管理和治疗指南中的减肥方式的理性建议提供证据。
项目成果
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LORRAINE S EVANGELISTA其他文献
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{{ truncateString('LORRAINE S EVANGELISTA', 18)}}的其他基金
Examining the Effects of High Protein Diet on Outcomes in Heart Failure Patients
检查高蛋白饮食对心力衰竭患者预后的影响
- 批准号:
7507339 - 财政年份:2009
- 资助金额:
$ 45.5万 - 项目类别:
Examining the Effects of High Protein Diet on Outcomes in Heart Failure Patients
检查高蛋白饮食对心力衰竭患者预后的影响
- 批准号:
8309577 - 财政年份:2009
- 资助金额:
$ 45.5万 - 项目类别:
Examining the Effects of High Protein Diet on Outcomes in Heart Failure Patients
检查高蛋白饮食对心力衰竭患者预后的影响
- 批准号:
8392251 - 财政年份:2009
- 资助金额:
$ 45.5万 - 项目类别:
Examining the Effects of High Protein Diet on Outcomes in Heart Failure Patients
检查高蛋白饮食对心力衰竭患者预后的影响
- 批准号:
7915297 - 财政年份:2009
- 资助金额:
$ 45.5万 - 项目类别:
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