Low-dose Myocardial Perfusion Imaging by CT

CT 低剂量心肌灌注成像

• 批准号: 8290709
• 负责人: Adam M Alessio
• 金额: $ 44.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-17 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290709
• 关键词: Algorithms; Anatomy; Behavior; Blood flow; Cardiac; Catheterization; Clinical; Computer software; Consensus; Contrast Media; Coronary heart disease; Coupled; Data; Diagnostic; Disease; Dose; Flow-It; Goals; Heart; Image; Image Enhancement; Imaging Techniques; Ionizing radiation; Kinetics; Knowledge; Low Dose Radiation; Mainstreaming; Manufacturer Name; Measures; Methods; Modeling; Myocardial; Myocardial perfusion; Noise; Nuclear; Patients; Performance; Perfusion; Physiology; Positioning Attribute; Positron-Emission Tomography; Procedures; Process; Protocols documentation; Radiation; Resolution; Sampling; Scanning; Scheme; Severities; Techniques; Time; Tube; Variant; Work; X-Ray Computed Tomography; attenuation; base; blood flow measurement; clinical application; data acquisition; image reconstruction; improved; mathematical model; novel; novel strategies; patient safety; reconstruction; research and development; restoration; simulation; tool

DESCRIPTION (provided by applicant) The objective of this proposal is to develop clinically viable strategies for the quantitative estimation of myocardial blood flow (MBF) from dynamic computed tomography (CT) imaging with low radiation doses comparable to those received in common nuclear myocardial perfusion studies. Despite the proven clinical value of quantifying MBF (in ml/g/min), there are no widespread clinical methods to easily measure MBF in absolute units. Dynamic CT offers the potential to quantify flow, but the radiation dose imparted from these studies prohibits widespread acceptance. The specific aims of the proposal are to develop 1) optimal myocardial blood flow estimation methods, 2) low-dose dynamic CT acquisition strategies for MBF estimation, 3) unbiased data restoration algorithms and 4) image reconstruction methods based on trading off spatial resolution for noise reduction and constraining noise with a priori knowledge. These aims will be developed with simulations of dynamic contrast enhanced CT imaging and evaluated with patient exams. We hypothesize that accurate subendo- and subepi-cardial MBF estimates can be determined with low- dose dynamic CT through selection of acquisition strategies and judicious application of noise reduction strategies. This work proposes novel low-dose acquisition and data/image enhancement strategies to enable accurate quantitative estimates of blood flow in absolute units of ml/g/min. These methods will allow for substantial reductions in radiation dose, which is essential for patient safety, clinical application of dynamic CT for MBF measurement, and for other proven applications of dynamic CT. This work will position cardiac dynamic CT as a safe, easy, and widely available tool for quantitative MBF estimation, providing valuable clinical information for quantification of flow limiting disease, minimizing unnecessary catheterization procedures, informing therapy choices, and developing new therapies. PUBLIC HEALTH RELEVANCE: A quantitative estimate of blood flow in the heart provides valuable clinical information regarding the severity and extent of coronary heart disease. Dynamic computed tomography (CT) offers the potential to quantify blood flow, but it is not widely accepted because of the radiation dose associated with these studies. This proposal will develop strategies to substantially reduce the radiation dose from dynamic CT, enabling quantitative myocardial blood flow estimation from an easy, widely available, and safe CT imaging study.

描述（由申请人提供）本提案的目的是开发可行的临床可行策略，以定量估计动态计算机断层扫描（CT）成像的心肌流动（MBF），其辐射剂量低，可与常见的核心肌灌注研究相当。尽管量化MBF的临床价值（以ML/g/min为单位），但尚无广泛的临床方法来轻松地测量绝对单位的MBF。动态CT提供了量化流量的潜力，但是从这些研究中赋予的辐射剂量禁止接受广泛接受。该提案的具体目的是开发1）最佳的心肌血流估计方法，2）低剂量动态CT估算的动态CT采集策略，3）基于对降低噪音和先前知识的空间分辨率的差异分辨率的无偏数据恢复算法和4）图像重建方法。这些目标将通过动态对比度增强CT成像的模拟开发，并通过患者检查进行评估。我们假设可以通过选择采集策略并明智地应用降低降噪策略来确定准确的亚内多和亚皮亚和亚皮亚电脑MBF估计值。这项工作提出了新型的低剂量获取和数据/图像增强策略，以实现ML/G/min绝对单位中血流的准确定量估计。这些方法将大大减少辐射剂量，这对于患者安全至关重要，动态CT用于MBF测量以及动态CT的其他经过验证的应用。这项工作将将心脏动态CT定位为一种安全，简单且可广泛的工具，用于定量MBF估计，为量​​化流量限制疾病的量化提供了宝贵的临床信息，最大程度地减少了不必要的导管插入程序，为治疗选择提供了信息，并开发了新的疗法。 公共卫生相关性：心脏血流的定量估计值提供了有关冠心病的严重程度和程度的宝贵临床信息。动态计算机断层扫描（CT）提供了量化血流的潜力，但由于与这些研究相关的辐射剂量，并未被广泛接受。该建议将制定策略，从而从动态CT中大大减少辐射剂量，从而从一项简单，可用和安全的CT成像研究中实现定量的心肌血流估计。