Neurobiological Mechanisms of Impulse Control Problems

冲动控制问题的神经生物学机制

基本信息

批准号：
8301683
负责人：
Edward M. Bernat
金额：
$ 14.95万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8301683
关键词：
Address Aggressive behavior Anterior Area Attenuated Award Behavior Brain Brain region Cognitive Cognitive deficits Communities Complex Computing Methodologies Cues Data Data Analyses Data Set Dependence Development Disease EP300 gene Electroencephalography Event Event-Related Potentials Feedback Frequencies Goals Growth Imprisonment Impulsivity Individual Joints Label Learning Link Literature Magnetic Resonance Imaging Maintenance Measurement Measures Medial Mediating Mentorship Methods Modeling Neurobiology P300 Event-Related Potentials Participant Personality Traits Phase Positioning Attribute Prisoner Process Protocols documentation Psychopathology Research Research Design Research Personnel Rewards Role Sampling Series Signal Transduction Source Specificity Substance Addiction Syndrome System Techniques Theoretical model Time Training Training Activity Work anti social base cingulate cortex cognitive control imaging modality neurobiological mechanism neuromechanism programs relating to nervous system response skills theories

项目摘要

The broad aim of the proposed program of work is to investigate neurobiological and cognitive mechanisms underlying impulse control (externalizing) problems. The proposed work builds on the applicant.Aos involvement in the development of a hierarchical model of externalizing. The core idea of this model is that a general vulnerability factor, labeled externalizing, underlies and unites psychopathologicalsyndromes involving antisocial behavior and substance dependence, as well as personality traits reflecting impulsivity and aggression. These problems are conceptualized in terms of deficits involving anterior brain regions, although researchers are only really beginning to understand how these regions work. The most established correlate of externalizing problems is reduced amplitude of the P300 event-related potential (ERP) brain component. However, neural mechanisms underlying P300 are distributed and not well understood. Thus, studies of P300 amplitude reductions have not produced good models about the neural mechanisms involved. Researchers have recently begun investigating amplitude reductions in the error-related negativity (ERN) ERP brain component related to externalizing-related disorders. The ERN is understood to involve a relatively strong activation of the anterior cingulate cortex (ACC), providing a clearer target for study. Current models of the ERN suggest that it is best understood as an ACC activation which is influenced by other brain regions depending on the circumstances, particularly the PFC. The goal of the proposed work is to investigate the roles of the PFC and ACC during the ERN under different task circumstances, and then to investigate how these relationships are modulated in individuals with externalizing problems. The primary training components involve developing skills in direct approaches to the measurement of specific brain regions to address the question of the relationship between the PFC and ACC in externalizing psychopathology. Recent years have seen incredible growth in methods for localizing neural sources, and currently available techniques offer strong possibilities for inferring ACC and PFC sources using ERP, magnetic resonance imaging (MRI), and combined (multimodal) ERP and MRI approaches. The proposed training activities would provide training in all three approaches, with mentorship by a leading expert in this field. The candidate also brings strong expertise in joint time-frequency (TF) analysis, an emerging computational method for electrophysiological signals. An important secondary goal is to integrate TF approaches with these neural source localization methods, to create cutting-edge methods neural source methods. The long term goal is for the candidate to become an independent investigator focused on externalizing psychopathology, employing cutting-edge methods for inferring neural sources as described.

拟议工作计划的总体目标是研究神经生物学和认知机制潜在的冲动控制（外化）问题。拟议的工作以申请人为基础。Aos 参与外化层次模型的开发。该模型的核心思想是一般的脆弱性因素，被称为外在化，是精神病理学综合症的基础和联合体涉及反社会行为和物质依赖，以及反映冲动的人格特征和侵略性。这些问题是根据涉及前脑区域的缺陷来概念化的，尽管研究人员才真正开始了解这些区域是如何运作的。最成熟的外化问题的相关因素是 P300 事件相关电位 (ERP) 大脑振幅降低成分。然而，P300 背后的神经机制是分布式的，目前尚不清楚。因此， P300 振幅降低的研究尚未产生关于神经机制的良好模型涉及。研究人员最近开始研究与误差相关的负值的振幅降低 (ERN) 与外化相关疾病相关的 ERP 大脑成分。据了解，ERN 涉及前扣带皮层（ACC）的激活相对较强，为研究提供了更明确的目标。当前的 ERN 模型表明最好将其理解为受其他大脑影响的 ACC 激活区域取决于具体情况，特别是 PFC。拟议工作的目标是研究不同任务环境下 ERN 期间 PFC 和 ACC 的作用，然后研究这些关系在具有外化问题的个体中是如何调节的。主要培训内容包括培养直接测量方法的技能特定的大脑区域来解决 PFC 和 ACC 在外化过程中的关系问题精神病理学。近年来，定位神经源的方法取得了令人难以置信的增长，并且目前可用的技术为使用 ERP 推断 ACC 和 PFC 来源提供了强大的可能性，磁共振成像 (MRI) 以及联合（多模式）ERP 和 MRI 方法。拟议的培训活动将提供所有三种方法的培训，并由这方面的领先专家提供指导场地。该候选人还带来了联合时频 (TF) 分析方面的强大专业知识，这是一种新兴的技术电生理信号的计算方法。一个重要的次要目标是整合 TF 使用这些神经源定位方法，创建尖端方法神经源方法。长期目标是让候选人成为一名独立调查员，专注于外化精神病理学，采用尖端方法来推断所描述的神经源。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology.

DOI：
10.1111/psyp.13618
发表时间：
2020-07
期刊：
Psychophysiology
影响因子：
3.7
作者：
Bernat EM;Ellis JS;Bachman MD;Hicks BM
通讯作者：
Hicks BM

Anterior cingulate activity to monetary loss and basal ganglia activity to monetary gain uniquely contribute to the feedback negativity.

DOI：
10.1016/j.clinph.2014.08.025
发表时间：
2015-07
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
0
作者：
Foti D;Weinberg A;Bernat EM;Proudfit GH
通讯作者：
Proudfit GH

Sequential gains and losses during gambling feedback: Differential effects in time-frequency delta and theta measures.