US-France Research Collaboration on Neuroimaging Studies of Alcoholism

美法酒精中毒神经影像学研究合作

• 批准号: 8317640
• 负责人: EDITH VIONI SULLIVAN
• 金额: $ 28.12万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317640
• 关键词: Alcohol consumption; Alcoholism; Alcohols; Amnesia; Award; Brain; Chronic; Clinical; Cognition; Cognitive; Collaborations; Data; Diffusion Magnetic Resonance Imaging; Dysmorphology; France; Functional Magnetic Resonance Imaging; Heterogeneity; Human; Individual Differences; International; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Motor; NIH Program Announcements; Nervous system structure; Neuraxis; Neuropsychological Tests; Neurosciences; Nutritional; Nutritional status; Pattern; Process; Protocols documentation; Recording of previous events; Research; Retrieval; Sampling; Severities; Site; Structure; Symptoms; Testing; Tissues; U-Series Cooperative Agreements; Variant; Wernicke-Korsakoff Syndrome; Withdrawal; Withdrawal Symptom; design; drinking; in vivo; neuroimaging; neuropathology; problem drinker; prospective; response; white matter

DESCRIPTION (provided by applicant): This application for a U01 cooperative agreement award is in response to Program Announcement (PA) number PAR-08-004, "International Research Collaboration on Alcohol and Alcoholism." The award will enable an international collaboration between two INSERM sites in France (Orsay and Caen) and our US neuroscience laboratories to investigate the consequences of chronic alcoholism on central nervous system structure and function. Our international collaboration provides a unique opportunity to examine within and across cultural variation a broad range of alcoholism-related neuropathology, measured in vivo with structural magnetic resonance imaging (MRI); brain microstructure, circuitry, and tissue quality, measured with diffusion tensor imaging (DTI); and selective brain functions, measured with functional MRI (fMRI) and neuropsychological tests of component processes of cognition, memory, and motor abilities. Human alcoholism is marked by considerable heterogeneity in its consequences on brain structure and function. This multi-site project will be an efficient approach for testing the overarching hypothesis that the heterogeneity of alcoholic consequences on brain structure and function are due substantially to individual differences in pattern of alcohol use, nutritional status, and history of withdrawal symptoms. In both the US and France, the target subject samples will span clinical manifestations from uncomplicated alcoholics to those with the profound amnesia of Korsakoff's Syndrome (KS) and will enable testing of hypotheses about factors contributing to the heterogeneity of alcoholism neuropathology. The Specific Aims of this proposal are to 1. Determine the influence of three classes of clinical variables-drinking pattern, nutritional history and status, and withdrawal history-on a) Alcoholism-related brain dysmorphology measured on legacy and prospective MRI data collected in the US and France from alcoholics with graded symptom severity b) Alcoholism-related white matter deficits measured on legacy and prospective DTI data collected in the US and France in alcoholics with graded symptom severity 2. Develop in the US and export to France fMRI and DTI protocols designed to examine and dissociate a) Cognitive frontocerebellar and frontal motor circuitry b) Limbic circuitry disruption to distinguish encoding from retrieval deficits in explicit memory.

描述（由申请人提供）：本申请U01合作协议奖是针对计划公告（PA）编号PAR-08-004，“国际酒精和酒精中毒研究合作”。该奖项将使法国的两个Inserm网站（Orsay and Caen）与我们的美国神经科学实验室之间进行国际合作，以调查慢性酒精中毒对中枢神经系统结构和功能的后果。我们的国际合作提供了一个独特的机会，可以在文化变异内和跨文化变化中进行广泛的与酒精中毒相关的神经病理学，并通过结构磁共振成像（MRI）在体内测量；大脑微结构，电路和组织质量，通过扩散张量成像（DTI）测量；以及通过功能性MRI（fMRI）和对认知，记忆和运动能力的组成过程的神经心理学测试测量的选择性大脑功能。人类酒精中毒的标志是其对大脑结构和功能的影响很大。这个多站点项目将是测试总体假设的有效方法，即酒精性后果对大脑结构和功能的异质性基本上是由于酒精使用模式，营养状况以及戒断症状的病史的个体差异。在美国和法国，目标受试者样本将涵盖临床表现，从简单的酗酒者到患有科萨科夫综合征（KS）深刻的失忆症患者，并能够对有助于酗酒神经病学异质性的因素进行假设测试。该提案的具体目的是1。确定三类临床变量模式，营养历史和状态以及戒断历史的影响a）与酒精中毒相关的脑畸形学衡量的遗产和前瞻性MRI数据，在美国在美国和法国从饮酒中收集的遗传和法国在饮酒方面收集的症状和毒品的毒品差异b）对酒精降低的毒品进行了验证，并在酒精中毒中进行了验证b）毒品的差异b）饮酒量b）毒品差异。法国在戒酒中的症状严重程度2。