The Role of Depression in the development of Alcohol Problems Among Adolescents

抑郁症在青少年酒精问题发展中的作用

• 批准号: 8243693
• 负责人: CAROLYN A MC CARTY
• 金额: $ 24.01万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8243693
• 关键词: 18 year old; Accounting; Address; Adolescence; Adolescent; Adolescent Development; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Americas; Collection; Communities; Consensus; Data; Data Set; Development; Developmental Process; Diagnosis; Disease; Drug usage; Economics; Effectiveness; Epidemiology; Etiology; Family; Funding; Growth; Incidence; Longitudinal Studies; Mediating; Mental Depression; Modeling; NIH Program Announcements; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Pathway interactions; Play; Population; Prevalence; Prevention strategy; Preventive Intervention; Process; Psychopathology; Public Health; Recruitment Activity; Research; Research Project Grants; Risk; Risk Factors; Role; Sampling; Sampling Studies; Schools; Severities; Sex Characteristics; Stress; Surgeon; Temperament; Testing; Time; Youth; alcohol and other drug; alcohol involvement; alcohol related problem; alcohol risk; alcohol use initiation; base; boys; contextual factors; cost; depressive symptoms; early adolescence; girls; peer; prevent; pubertal timing; public health relevance; response; social; treatment strategy; underage drinking; underage drinking reduction

DESCRIPTION (provided by applicant): This application is submitted to NIAAA in response to Program Announcement 08-167 Secondary Analysis of Existing Alcohol Epidemiological Data which was created to support "studies that more fully utilize currently available data sets to increase our understanding of the incidence, prevalence and etiology of alcohol related problems and disorders in the population, as well as the risk and protective factors associated with them." This study will address the question of whether and how depressive symptoms, in isolation and in combination with conduct problems, developmental processes, and social contextual risk factors, influence the development of problematic alcohol use in adolescence. The Developmental Pathways Project (DPP) is a community-based longitudinal study that aims to understand developmental trajectories for depression, and comorbid conduct problems, across the adolescent period. DPP constitutes a racially diverse sample of 521 boys and girls who were recruited as sixth graders (age 11-12) from an urban school district. The sample has been followed over the course of six years, to age 17-18. The study sample was originally stratified on psychopathology risk status, and adolescents with depressive and conduct problems were oversampled. DPP has been collecting extensive data on alcohol and other drug use since its inception and is also determining 12-month diagnoses of Alcohol Abuse and Dependence at the 12th grade (17-18 year-old) assessment. In our first aim, we will compare empirical models examining depression and conduct problems as separate main effects, as interactive, and as related to alcohol use only by virtue of common antecedents, exploring overall growth, severity, persistence, and time-sensitive effects. Aim 2 will build up a more comprehensive model of alcohol problems by incorporating developmental processes and social-contextual factors that may mediate, moderate, and have direct effects on risk for the development of alcohol problems. The third aim focuses on the role of depression and conduct problems as they relate to early initiation and transition from use to problem use. Results will have direct implications for further refining and enhancing prevention and intervention approaches to bolster their effectiveness in reducing alcohol involvement and problems among youth. PUBLIC HEALTH RELEVANCE: The consumption of alcohol by underage youth in America constitutes a public health problem with serious social, economic, and personal costs. The results of the proposed study will inform the expansion of effective prevention and treatment strategies for alcohol-related problems in adolescence. This research is responsive to NIAAA's Underage Drinking Research Initiative, as well as the Surgeon General's Call to Action to Prevent and Reduce Underage Drinking.

描述（由申请人提供）：该申请旨在响应计划公告08-167对现有酒精流行病学数据的二次分析，该数据的二级分析是为了支持“更充分利用当前可用数据集的研究，以增加我们对酒精相关问题的发病率，流行和病因的理解，以及与人群中与之相关的风险和保护因素，以及与之相关的风险因素。这项研究将解决以下问题：抑郁症状，以及如何隔离和与行为问题，发育过程和社会上下文危险因素相结合，影响青春期中有问题的饮酒的发展。发展途径项目（DPP）是一项基于社区的纵向研究，旨在在整个青少年期间了解抑郁症的发育轨迹以及合并的行为问题。 DPP构成了521个男孩和女孩的种族多样化样本，这些样本是从一个城市学区招募的六年级学生（11-12岁）。在六年的时间为17-18岁的过程中，该样本已被遵循。该研究样本最初是根据心理病理学风险状况进行了分层的，并且抑郁症和行为问题的青少年被过采样了。自成立以来，DPP一直在收集有关酒精和其他毒品使用的大量数据，并且还确定了12个月的饮酒和12年级（17-18岁）评估的12个月诊断。在我们的第一个目标中，我们将比较研究抑郁症和引起问题作为单独的主要影响的经验模型，作为互动性，并且与酒精使用有关，仅借助共同的先例，探索总体生长，严重性，持久性和时间敏感的影响。 AIM 2将通过纳入可能导致，中度和直接影响酒精问题风险的发展过程和社会上下文因素来建立更全面的酒精问题模型。第三个目标集中于抑郁症的作用，并在与早期使用到问题的早期起步和过渡有关时进行问题。结果将对进一步完善和增强预防和干预方法的直接影响，以增强其在减少酒精参与和青年问题问题方面的有效性。 公共卫生相关性：美国未成年青年对酒精的消费构成了严重的社会，经济和个人成本的公共卫生问题。拟议的研究结果将为青春期与酒精相关问题的有效预防和治疗策略的扩展提供信息。这项研究对NIAAA的未成年饮酒研究计划有反应，以及外科医生的呼吁，以防止和减少未成年人的饮酒。