Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 7989378
• 负责人: Yingchun Zhang
• 金额: $ 8.98万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7989378
• 关键词: Age; Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel; public health relevance

DESCRIPTION (provided by applicant): As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women. PUBLIC HEALTH RELEVANCE: In this research proposal an urethrovaginal support and urethral function assessment (UUFA) technique will be developed based on an advanced electromechanical pelvis modeling approach. The primary impact of this research would lead to a minimally invasive technique to quantitatively assess urethrovaginal support and urethra function in women which are common etiologic factors associated with stress urinary incontinence (SUI). The UUFA technique will further help us characterize the specific changes associated with aging that cause the increase in prevalence of SUI in women.

描述（由申请人提供）：作为重新提交，拟议的五年计划将培训我并促进我进入独立的跨学科研究职业。我在生物医学工程、电气工程和机械工程领域的多学科背景以及在先进生物力学建模和电生理学建模研究方面的杰出经验培养了我对尿失禁（UI）进行跨学科生物医学研究的兴趣并赋予了我独特的优势。近期目标是为成为一名独立科学家的职业生涯做好准备，并开发一种基于尿道阴道支持和尿道功能评估（UUFA）技术的新型特定主题机电骨盆模型，以微创和定量评估这两个病因，并研究具体的病因。与衰老效应相关的变化导致女性 SUI 患病率增加。这项研究背后的中心假设是，可以使用特定于受试者的盆腔建模方法对女性尿道阴道支持和尿道功能以及衰老对女性 SUI 的影响进行微创和定量评估和表征。主要假设#1 是可以使用特定于受试者的电生理盆腔建模方法对女性尿道功能进行微创和定量评估。主要假设#2 是可以使用特定于受试者的生物力学骨盆建模方法对女性尿道阴道支持功能进行非侵入性定量评估。主要假设#3 是衰老会导致尿道阴道支持不良和/或尿道功能障碍，从而导致 SUI。主要假设#4 是可以创建女性节制概况来预测女性的临床节制状态，并为特定患者建议最佳治疗方式。我们提出四个具体目标 (SA) 来检验这些假设： SA #1：开发一种基于特定受试者电生理骨盆模型的尿道周围肌肉疲劳评估 (UMFA) 技术，以微创和定量评估女性的尿道功能。主要假设#1 将得到检验。 SA #2：开发一种基于特定受试者生物力学骨盆模型的尿道阴道支持功能评估 (USFA) 技术，以非侵入性和定量评估女性的尿道阴道支持功能。主要假设#2 将得到检验。 SA #3：使用由 UMFA 和 USFA 技术组成的 UUFA 技术，研究衰老对患有/未患有 SUI 的年轻/老年女性受试者的尿道功能和尿道阴道支持的影响。主要假设#3 将得到检验。 SA #4：利用 UUFA 技术定量表征女性尿道阴道支持和尿道功能中 SUI 的病因因素，制定女性 SUI 概况作为女性 SUI 的临床标准。主要假设#4 将得到检验。在该项目完成后，我们期望我们能够建立并验证 UUFA 技术及其在临床研究中应用的可行性，并更好地了解与衰老和更年期相关的特定变化对这些变化的贡献。女性的病因因素。 公共健康相关性：在本研究提案中，将基于先进的机电骨盆建模方法开发尿道阴道支持和尿道功能评估 (UUFA) 技术。这项研究的主要影响将是开发一种微创技术来定量评估女性尿道阴道支持和尿道功能，这是与压力性尿失禁 (SUI) 相关的常见病因。 UUFA 技术将进一步帮助我们描述与衰老相关的特定变化，这些变化导致女性 SUI 患病率增加。