Mid-Career Mentoring Award for Patient-Oriented Research in Aging

以患者为导向的老龄化研究职业中期指导奖

• 批准号: 8045182
• 负责人: EDWARD R MARCANTONIO
• 金额: $ 19.1万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8045182
• 关键词: Mid; Career; Mentoring; Award; Patient

DESCRIPTION (provided by applicant): I, Edward R. Marcantonio, MD, SM, am a board-certified geriatrician and patient-oriented aging researcher, Associate Professor of Medicine at Harvard Medical School (HMS) and Director of Research in the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center (BIDMC). The long term objectives of my career are to conduct patient-oriented research (POR) to improve the quality of care and outcomes of hospitalized older adults, and to provide mentoring to new investigators interested in POR in aging. Over the past 16 years, I have built a successful, independent, NIH-funded program of research focused on delirium (acute confusion), a common, morbid and costly condition in hospitalized older adults. I have conducted a series of observational and interventional studies designed to improve diagnosis, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. Through these studies, I have gained the knowledge and skills necessary to conduct high quality POR and to mentor new investigators, and have been recognized for my excellence in mentoring with two prestigious awards. In this context, the primary objectives of this K24 Award are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium. This objective will be accomplished through my currently funded studies, including an NIA-funded R01 entitled 3D-CAM: Deriving and validating a 3-Minute Diagnostic Assessment for Delirium, and my new research, a Biomarker Discovery for Delirium project described in this application. Receipt of the K24 will enable me to more effectively leverage these studies and other ongoing work to support the work of trainees, who will in turn expand my research program. 2. To build a mentorship program that will expand POR in aging at BIDMC and HMS, with a focus on delirium and related conditions. This objective will be accomplished through structured, individual mentorship of young investigators with a strong interest in POR. Protected time for mentorship will be provided by the K24 award. 3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. This objective will be accomplished through my new research project, career development activities, and interdisciplinary collaborations that will be facilitated by receipt of the K24 award. My objectives will be greatly facilitated by the superb academic environment and outstanding institutional support provided by HMS and the BIDMC Divisions of General Medicine and Gerontology. PUBLIC HEALTH RELEVANCE: Delirium (acute confusion) complicates over 25% of the more than 12 million hospital stays per year of older adults in the U.S., leading to substantial morbidity, mortality, and cost. The goals of this K24 Award are to conduct patient-oriented research (POR) in the field of delirium, and to train new investigators in POR focused on improving diagnosis, monitoring, and treatment of delirium. The ultimate goal of this Award is to expand research activity and capacity in this critically important area, thereby improving the health of seniors.

描述（由申请人提供）：我，Edward R. Marcantonio，医学博士、SM，是一名经过委员会认证的老年病学家和以患者为导向的老龄化研究员、哈佛医学院 (HMS) 医学副教授和医学部研究主任贝斯以色列女执事医疗中心 (BIDMC) 的普通医学和初级保健。我职业生涯的长期目标是进行以患者为导向的研究 (POR)，以提高住院老年人的护理质量和结果，并为对老龄化 POR 感兴趣的新研究人员提供指导。在过去的 16 年里，我建立了一个成功的、独立的、由 NIH 资助的研究项目，重点关注谵妄（急性精神错乱），这是住院老年人中一种常见的病态且代价高昂的疾病。我进行了一系列观察性和干预性研究，旨在改善诊断、针对高危人群、识别可改变的风险因素，并测试干预策略以降低谵妄的发生率、严重程度和持续时间。通过这些研究，我获得了进行高质量 POR 和指导新研究人员所需的知识和技能，并因在指导方面的卓越表现而获得两项享有盛誉的奖项。在此背景下，K24 奖的主要目标是： 1. 继续围绕改善患有谵妄的住院老年人的护理质量和结果建立研究计划。这一目标将通过我目前资助的研究来实现，包括 NIA 资助的 R01，题为 3D-CAM：推导和验证谵妄的 3 分钟诊断评估，以及我的新研究，本申请中描述的谵妄生物标记物发现项目。收到 K24 将使我能够更有效地利用这些研究和其他正在进行的工作来支持受训者的工作，而受训者又将扩大我的研究计划。 2. 建立一个指导计划，扩大 BIDMC 和 HMS 老龄化领域的 POR，重点关注谵妄和相关病症。这一目标将通过对 POR 有浓厚兴趣的年轻研究人员进行结构化、个人指导来实现。 K24 奖项将提供受保护的指导时间。 3. 扩大我的指导计划，包括围绕谵妄生物标志物发现的转化、跨学科工作，以及生物标志物应用，以改善老年人谵妄患者的风险分层、诊断和预后。这一目标将通过我的新研究项目、职业发展活动和跨学科合作来实现，而获得 K24 奖将促进这些合作。 HMS 和 BIDMC 普通医学和老年学部门提供的一流学术环境和出色的机构支持将极大地促进我的目标的实现。 公共卫生相关性：在美国，每年超过 1200 万例住院的老年人中，超过 25% 的人因谵妄（急性精神错乱）而变得复杂化，从而导致大量的发病率、死亡率和费用。该 K24 奖的目标是在谵妄领域开展以患者为导向的研究 (POR)，并培训 POR 领域的新研究人员，重点改进谵妄的诊断、监测和治疗。该奖项的最终目标是扩大这一至关重要领域的研究活动和能力，从而改善老年人的健康。