Quantitative Biology: a Graduate Curriculum Linking the Physical and Biomedical S

定量生物学：连接物理和生物医学的研究生课程

• 批准号: 7797603
• 负责人: JEFF GELLES
• 金额: $ 26.69万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797603
• 关键词: Biology; Educational Curriculum; Link

DESCRIPTION (provided by applicant): The second half of the last century produced a staggering wealth of information about the cellular and molecular processes of life. The quantity and quality of this data is ushering in a new mode of thinking in the biomedical sciences that relies heavily on mathematical and computational tools and on rigorous quantitative experimental methods. With increasing frequency, the analytical tools and experimental methods are not home grown within the life sciences, but are adopted from research in the physical sciences. This brave new world requires a new kind of researcher, one who easily moves between the bench and the workstation, one who is equally at ease with running microscopes as with running simulations, and one for whom building quantitative models and testing them by designing equally quantitative experiments comes naturally. The Quantitative Biology (QB) Program at Brandeis University brings together six different Ph.D. programs from four science departments in order to train students who can rise to this interdisciplinary challenge. QB is an official interdepartmental graduate program at Brandeis that has just completed its second full academic year of operation; the program currently has 21 enrolled students. QB leverages the strengths of existing disciplinary Ph.D. programs at Brandeis by bringing together students from these programs in a specialized curriculum that is designed to take advantage of the learning opportunities afforded by training in multi-disciplinary groups. Students admitted to graduate study in the Biochemistry, Biophysics & Structural Biology, Chemistry, Molecular & Cellular Biology, Neuroscience, or Physics Ph.D. programs and who choose the QB track will, upon successful completion, receive a Ph.D. degree in their chosen discipline "with an additional specialization in Quantitative Biology". This approach provides the students with modern discipline-bridging training while providing the graduate with a Ph.D. credential that has proven value on the job market because it is in a recognized traditional discipline. Students typically enter the QB program in either the first or second years of their Ph.D. studies and remain affiliated with QB until they graduate. Each student selected for support by the training grant will be supported during years 2 and 3 of their studies. RELEVANCE: The goal of the Quantitative Biology program is to train Ph.D. scientists who are well equipped to bring quantitative experimental, computational, and mathematical methods from Physics and Chemistry to bear on important problems in biomedical research. It is anticipated that the work of these scientists will lead to improvements in public health by advancing basic research in directions that are not readily accessible to scientists who lack interdisciplinary training.

描述（由申请人提供）：上世纪下半叶产生了关于生命细胞和分子过程的惊人丰富的信息。这些数据的数量和质量正在为生物医学科学带来一种新的思维模式，这种思维模式在很大程度上依赖于数学和计算工具以及严格的定量实验方法。随着频率的增加，分析工具和实验方法不再是生命科学领域自行开发的，而是从物理科学研究中采用的。这个美丽的新世界需要一种新型的研究人员，能够轻松地在工作台和工作站之间移动的人，能够像运行模拟一样轻松地运行显微镜的人，能够构建定量模型并通过同样定量的设计来测试它们的人。实验是自然而然的。布兰代斯大学的定量生物学 (QB) 项目汇集了六位不同的博士生。四个科学系的项目旨在培养能够应对这一跨学科挑战的学生。 QB 是布兰迪斯大学的一个官方跨院系研究生项目，刚刚完成其第二个完整学年的运营；该项目目前有21名注册学生。 QB利用 现有学科博士的优势布兰代斯大学的项目将来自这些学校的学生聚集在一起 专门课程中的课程旨在利用多学科小组培训提供的学习机会。学生被录取攻读生物化学、生物物理学和结构生物学、化学、分子和细胞生物学、神经科学或物理学博士学位的研究生课程。计划并选择 QB 轨道的人在成功完成后将获得博士学位。他们所选择的学科的学位“以及定量生物学的额外专业”。这种方法为学生提供了现代学科衔接培训，同时为毕业生提供了博士学位。已在就业市场证明其价值的证书，因为它属于公认的传统学科。学生通常在博士学位的第一年或第二年进入 QB 课程。学习并继续隶属于 QB 直至毕业。每位被选拔接受培训补助金支持的学生都将在其学习的第二年和第三年获得支持。 相关性：定量生物学项目的目标是培养博士生。科学家有能力将物理和化学中的定量实验、计算和数学方法应用于生物医学研究中的重要问题。预计这些科学家的工作将通过向缺乏跨学科培训的科学家难以接近的方向推进基础研究，从而改善公共卫生。