Epidemiology and Genetics of Skeletal Muscle Composition

骨骼肌组成的流行病学和遗传学

• 批准号: 8132812
• 负责人: IVA MILJKOVIC
• 金额: $ 13.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132812
• 关键词: Adipose tissue; Admixture; African; Age; Aging; Alcohols; Area; Biology; Body fat; Candidate Disease Gene; Caribbean region; Caucasians; Caucasoid Race; Cohort Studies; Confounding Factors (Epidemiology); DNA Resequencing; Data; Diabetes Mellitus; Disease; Elderly; Epidemiology; Equipment and supply inventories; Evaluation; Family; Fatty acid glycerol esters; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Genotype; Glucose; Goals; Health; Human; Hyperglycemia; Image; Individual; Infiltration; Insulin; Insulin Resistance; Intramuscular; Learning; Longitudinal Studies; Low Prevalence; Measures; Metabolic Diseases; Metabolism; Muscle; Obesity; Pattern; Pharmacotherapy; Population; Recruitment Activity; Sampling; Scanning; Sequence Analysis; Skeletal Muscle; Smoking; Testing; Time; Tobago; Variant; Woman; X-Ray Computed Tomography; aged; cohort; density; ethnic difference; experience; follow-up; genetic epidemiology; genetic variant; human FABP4 protein; men; novel; skills; subcutaneous

DESCRIPTION (provided by applicant): Skeletal muscle fat accumulation, independent of overall body fat, may contribute to hyperglycemia and insulin resistance, disorders that are highly prevalent in populations of African origin. A few studies conducted mainly in women or in small samples, also suggest that individuals of African ancestry may have increased skeletal muscle fat compared to Caucasians, independent of overall body fat. However, much remains to be learned about the epidemiology of skeletal muscle composition and its relationship to metabolic disorders, particularly in populations of African ancestry. The goal of the proposed application is to characterize the epidemiology of ectopic skeletal muscle fat. Components of skeletal muscle composition including muscle cross-sectional area, total, subcutaneous, and intermuscular adipose tissue areas, and skeletal muscle density will be measured from existing quantitative computed tomography (pQCT) scans in 2200 men of Caucasian and African descent. The specific aims are to: (1) determine if there are ethnic differences in the distribution of skeletal muscle fat; (2) evaluate if genetic variations in the fatty-acid binding protein 4 gene contribute to skeletal muscle composition in men of African and Caucasian ancestry; and (3) to test the hypothesis that skeletal muscle fat increases with advancing age. The candidate's goals are to: (1) acquire new skills in quantitative computed tomography imaging of skeletal muscle composition; (2) become proficient in high-throughput genotyping and DMA sequence analysis; (3) obtain field experience in conducting longitudinal studies of skeletal muscle composition. PUBLIC HEALTH RELEVANCE: The accomplishment of the proposed aims will greatly enhance our understanding of the epidemiology and genetics of ectopic fat infiltration in skeletal muscle and its relationship to diabetes.

描述（由申请人提供）： 骨骼肌脂肪积累与全身脂肪无关，可能会导致高血糖和胰岛素抵抗，这些疾病在非洲裔人群中非常普遍。一些主要针对女性或小样本进行的研究还表明，与白人相比，非洲血统的人骨骼肌脂肪可能有所增加，而与整体身体脂肪无关。然而，关于骨骼肌组成的流行病学及其与代谢紊乱的关系，特别是在非洲血统的人群中，还有很多东西有待了解。所提出的应用程序的目标是描述异位骨骼肌脂肪的流行病学特征。骨骼肌组成的组成部分，包括肌肉横截面积、总脂肪、皮下脂肪和肌间脂肪组织面积以及骨骼肌密度，将通过对 2200 名白种人和非洲人后裔男性的现有定量计算机断层扫描 (pQCT) 扫描进行测量。具体目标是：（1）确定骨骼肌脂肪的分布是否存在种族差异； (2) 评估脂肪酸结合蛋白 4 基因的遗传变异是否影响非洲和高加索血统男性的骨骼肌组成； （3）检验骨骼肌脂肪随着年龄增长而增加的假设。候选人的目标是：（1）获得骨骼肌成分定量计算机断层扫描成像的新技能； (2) 精通高通量基因分型和DMA序列分析； (3) 获得进行骨骼肌成分纵向研究的现场经验。 公共健康相关性：所提出的目标的实现将极大地增强我们对骨骼肌异位脂肪浸润的流行病学和遗传学及其与糖尿病关系的理解。