Molecular and Cellular Basis for Digestive Diseases

消化系统疾病的分子和细胞基础

• 批准号: 8075516
• 负责人: RICHARD M. PEEK
• 金额: $ 113.26万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8075516
• 关键词: Molecular; Cellular; Basis; Digestive; Diseases

This application is for continued support of the Vanderbilt Digestive Disease Research Center (VDDRC) focused on the study of the molecular and cellular mechanisms responsible for digestive diseases. We believe that a fundamental understanding of these processes will provide a rational basis for development of targeted prevention and therapies. The VDDRC is multidisciplinary, including faculty in 10 different academic departments with 77 investigators (50 full members and 27 associate members). The Aims of the VDDRC are aligned with the goals of Vanderbilt University: 1) to promote digestive diseases-related research in an integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of VDDRC Members; 3) to attract investigators not involved in digestive diseases-related research to pursue these lines of investigation; 4) to develop and implement programs for training, establishment, and retention of young investigators in digestive disease-related research; and 5) to facilitate the transfer of basic research findings to improvements in prevention and/or clinical care. Investigative interests of the members fall into four broad areas of study: 1) growth, proliferation, and apoptosis, 2) epithelial integrity, 3) gastrointestinal development and function, and 4) gastrointestinal physiology, obesity, and metabolism. The VDDRC contains five core research laboratories to support the members: 1) the Microarray Core, 2) the Cellular and Animal Modeling Core, 3) the Cell Imaging Core, 4) the Bioanalytical (Mass Spectrometry) and Proteomics Core, and 5) the Flow Cytometry Core. These are integrated into our Center to provide investigators working on digestive disease-related research with the latest advances in technology and aid in experimental design and interpretation of results. The VDDRC supports a Pilot/Feasibility Program including a university-supported translational project, and a Young Investigator Award Program to foster participation of beginning and seasoned investigators in research related to digestive diseases. The Administrative Core also contains Biostatistical and Enrichment Programs and oversees the financial management and operation of the VDDRC. The VDDRC Research Programs through technologies provided by the Research Cores are designed to improve prevention, management, outcomes or treatment of human digestive diseases.

该应用是为了持续支持范德比尔特消化疾病研究中心（VDDRC），重点是研究负责消化疾病的分子和细胞机制。我们认为，对这些过程的基本理解将为开发有针对性的预防和疗法提供合理的基础。 VDDRC是多学科的，包括10个不同学术部门的教职员工，有77名调查人员（50名成员和27名员工）。 VDDRC的目的与范德比尔特大学的目标保持一致：1）以综合，协作和多学科的方式促进与消化疾病相关的研究； 2）增强VDDRC成员的基础研究能力； 3）吸引不参与消化疾病有关的研究人员来进行这些调查渠道； 4）制定和实施计划，以培训，建立和保留年轻研究人员在与消化疾病有关的研究中； 5）促进基础研究结果转移到改善预防和/或临床护理方面。成员的调查兴趣属于四个广泛的研究领域：1）生长，增殖和凋亡，2）上皮完整性，3）胃肠道发育和功能，以及4）胃肠道生理，肥胖和代谢。 VDDRC包含五个支持成员的核心研究实验室：1）微阵列核心，2）细胞和动物建模核心，3）细胞成像核心，4）4）生物分析（质谱法）和蛋白质组学核心以及5）流动细胞仪核。这些都集成到我们的中心，以为研究人员提供与消化性疾病相关的研究的研究，并在技术方面取得了最新进展，并有助于实验设计和结果解释。 VDDRC支持一项试点/可行性计划，包括大学支持的翻译项目，以及一项年轻的研究者奖计划，以促进与消化疾病有关的研究和经验丰富的研究人员的参与。行政核心还包含生物统计学和丰富计划，并监督VDDRC的财务管理和运营。通过研究核心提供的技术，VDDRC研究计划旨在改善人类消化疾病的预防，管理，结果或治疗。