Pathology Core

病理学核心

• 批准号: 8291333
• 负责人: Jonathan W. Said
• 金额: $ 13.44万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291333
• 关键词: Accounting; Animal Model; Autopsy; Biological Assay; Biological Markers; Biopsy; Biostatistics Core; Cancer Center; Carcinoma; Classification; Clinical; Clinical Trials; Collaborations; Collection; Commit; Computer software; Confidentiality of Patient Information; Consent Forms; Consultations; Core Biopsy; Core Facility; Culture Media; DNA; Data; Databases; Diagnosis; Drug or chemical Tissue Distribution; Early Detection Research Network; Ensure; Evaluation; Excision; Experimental Designs; Fixatives; Formalin; Freezing; Fresh Tissue; Funding; Generations; Goals; Harvest; Histologic; Histology; Hospitals; Hour; Human; Immunohistochemistry; In Situ Hybridization; Informatics; Institutional Review Boards; Laboratories; Length; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Molecular; Mus; Neoplasm Metastasis; Normal tissue morphology; Operating Rooms; Operative Surgical Procedures; Outcome; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Policies; Procedures; Process; Prostate; Prostate carcinoma; Prostatectomy; Prostatic Neoplasms; Protocols documentation; Publications; Quality Control; RNA; Recurrence; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sampling; Schedule; Serum; Services; Source; Specimen; Sterility; Surgeon; Techniques; Temperature; Time; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Transurethral Resection; Urethra; Urine; Urology; Vision; Work; anticancer research; base; computerized; cryostat; follow-up; instrumentation; neoplastic; programs; prospective; sample fixation; tissue fixing; tissue processing; tumor

The prostate pathology core provides essential services to all projects in the SPORE with major commitment to tissue acquisition and processing, tissue histology and analysis including specialized techniques, and pathology consultation. The core is fully committed to collaboration with other SPORE and NCI programs, including the National Biospecimen Network (NBN), the Inter-SPORE Prostate Biomarker Study (IPBS), the NCI informatics grid (e.g. CA-BIG etc.), the Inter-SPORE Clinical Trial Concept Committee, and the Early Detection Research Network (EDRN). The core infrastructure includes a Pathology Coordinating Center which interacts with the SPORE Executive Committee to prioritize resources among competing projects. For tissue collection the core will expand existing resources including a functioning tissue bank funded by the Jonsson Cancer Center and the Departments of Pathology and Urology to provide services to the projects including harvesting, collection, and processing of fresh biopsy, prostatectomy, serum and urine specimens. Tissue will be collected from prostate core biopsies, prostatectomy specimens, trans-urethral resections, and metastatic tumor from surgical and autopsy specimens. All specimens will be evaluated pathologically by the Pi's (Dr. Said or Dr. Thomas) to ensure accurate and consistent classification and grading of tumors. The core will also provide a full range of services including processing, fixation, and embedding of human and murine tissues, routine histology, and specialized immunohistochemistry and in-situ hybridization studies. Particularly use will be made of high throughput techniques incorporating tissue arrays from over 500 cases of prostate carcinoma already prepared, as well as second generation arrays with samples related to outcome such as PSA recurrence and metastasis. A computerized database will be maintained of well-characterized matched samples of normal and neoplastic tissues. This database is electronically linked to the clinical database maintained by the SPORE Biostatistics core and the Department of Urology. The core will validate IRB approvals before performing studies, and will maintain patient confidentiality at all times. Core facilities include a histology laboratory, a fully automated immunohistochemistry laboratory, computerized instrumentation for quantitative immunohistochemistry, and a tissue array facility. One of the key contributions of this core is expert pathology consultative services. The Pi's have demonstrated expertise with prostate pathology, both clinical and experimental, involving human and murine tissue. The investigators will continue to work closely with SPORE investigators in experimental design, use of human and murine tissues, and analysis and interpretation of results. Drs. Said and Thomas have co-authored over 30 prostate cancer publications during the five years of SPORE funding, reflecting their engagement in the program and contribution of this core to prostate cancer research at UCLA.

前列腺病理学核心为孢子中的所有项目提供了重要的服务，并以重大承诺 进行组织采集和加工，组织组织学和分析，包括专业技术，以及 病理咨询。核心完全致力于与其他孢子和NCI计划合作， 包括国家生物测量网络（NBN），孢子间的前列腺生物标志物研究（IPB）， NCI信息学网格（例如CA-BIG等），跨越临床试验概念委员会和早期 检测研究网络（EDRN）。核心基础设施包括病理协调中心 它与孢子执行委员会互动以优先考虑竞争项目之间的资源。为了 组织收集核心将扩大现有资源，包括由 琼森癌症中心和病理学和泌尿科部门为项目提供服务 包括收集，收集和加工新鲜活检，前列腺切除术，血清和尿液标本。 组织将从前列腺核活检，前列腺切除术标本，经尿道切除术和 手术和尸检标本的转移性肿瘤。所有标本将通过病理评估 PI（Said Dr. sate或Thomas博士），以确保肿瘤的准确，一致的分类和分级。 核心还将提供全方位的服务，包括人类的处理，固定和嵌入 以及鼠组织，常规组织学以及专门的免疫组织化学和原位杂交 研究。特别的使用将由高吞吐量技术组合起来，从而 已经准备了500例前列腺癌，以及带有样品的第二代阵列 与PSA复发和转移等结果有关。将维护计算机数据库 特征良好的匹配正常和肿瘤组织的样品。该数据库是电子链接的 由孢子生物统计学核心和泌尿科部维护的临床数据库。这 核心将在进行学习之前验证IRB批准，并将保持患者的机密性 时代。核心设施包括组织学实验室，全自动免疫组织化学实验室， 用于定量免疫组织化学和组织阵列设施的计算机仪器。中的一个 该核心的主要贡献是专家病理咨询服务。 PI已经证明了 临床和实验性的前列腺病理学专业知识，涉及人类和鼠组织。这 调查人员将继续与孢子研究人员在实验设计中紧密合作，使用人类 以及鼠组织，以及结果的分析和解释。博士。说，托马斯合着了 30个前列腺癌出版物在孢子资金的五年中，反映了他们参与 该核心对加州大学洛杉矶分校前列腺癌研究的计划和贡献。