The Molecular Basis of Head and Neck Cancer Biology, Treatment and Prevention

头颈癌生物学、治疗和预防的分子基础

• 批准号: 8142073
• 负责人: GREGORY T WOLF
• 金额: $ 218.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-26 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142073
• 关键词: Molecular; Basis; Head; Neck; Cancer

A Specialized Program of Research Excellence for patients with cancer of the head and neck entitled "The Molecular Basis of Head and Neck Biology, Treatment and Prevention" is proposed that will significantly improve treatment results and reduce morbidity and mortality associated with this devastating malignancy. These goals will be achieved through improved understanding and application of molecular biology to the detection, prevention, treatment selection and development of new therapies for patients with head and neck cancers. Our ongoing hypothesis is that increased understanding of the molecular basis for treatment will allow more precise individualized patient selection that will result in less morbid therapy and improved quality of life, in addition to the possibility of better control of metastases and earlier detection or prevention of second primary malignancies. We propose continuation of this integrated translational research program consisting of four major projects that explore 1.) more specific treatment selection for patients likely to be cured with radiation or chemotherapy; 2.) new small molecule inhibitors of apoptosis-regulation to increase chemo/radiosensitivity; 3.) improved survival through development of sound prevention strategies; and 4.) the role of critical small molecules and chemoradiation sequencing for optimizing treatment results. These major translational projects are complemented by ongoing highly successful Career Development and Developmental Research Programs. All SPORE studies are supported by three Core Resources with demonstrated success in our initial funding period (Administration and Translational Trials Support, Biostatistics, and Tissue and Histopathology). Emphasis is placed on continued ongoing scientific review of all programs and core resources through utilization of an established Operations Committee, Senior Advisory Council and External Review Committee comprised of expert basic and clinician scientists in the field of cancer research. Strong institutional commitment in our initial funding period has been increased significantly in this renewal application to support equipment needs, our Developmental Research Program and provide increased flexibility to pursue further investigations of novel discoveries that are made as a result of these SPORE projects and collaborations. This Head and Neck SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. We have incorporated extensive use of Cancer Center core facilities and clinical and laboratory resources, and we draw heavily on experienced Cancer Center leadership. Superb teams of experienced clinical / basic collaborators combined with high institutional commitment and priority, and extensive patient resources provide an outstanding research environment that will ensure continued success in achieving overall SPORE goals.

提出了针对头颈癌患者的专业研究计划，标题为“头颈生物学，治疗和预防的分子基础”，这将显着改善治疗结果，并降低与这种破坏性恶性肿瘤相关的发病率和死亡率。这些目标将通过改善分子生物学对头颈癌患者的新疗法的检测，预防，治疗选择和开发的了解和应用来实现。我们正在进行的假设是，对治疗分子基础的了解增加将允许更精确的个性化患者选择，这将导致病态治疗和改善的生活质量，此外还可以更好地控制转移酶以及更早地检测或预防第二个初级恶性肿瘤。 我们提出了该综合翻译研究计划的延续，该计划由四个探索1的主要项目组成。）对可能治愈放射线或化学疗法治疗的患者的更具体的治疗选择； 2.）细胞凋亡调节的新小分子抑制剂增加化学/放射敏感性； 3.）通过制定预防策略来改善生存； 4.）关键小分子和化学放疗测序在优化治疗结果中的作用。这些主要的翻译项目得到了持续的非常成功的职业发展和发展研究计划的补充。所有孢子研究都得到了三个核心资源的支持，并在我们的初始资金期（管理和翻译试验支持，生物统计学以及组织以及组织病理学）中取得了成功。通过利用既定的运营委员会，高级顾问委员会和外部审查委员会的利用，重点是对所有计划和核心资源的持续科学审查，该委员会由癌症研究领域的专家基本和临床医生组成。在我们的初始资金期间，在这一续签应用中，我们的最初资助期间的强大机构承诺已大大提高，以支持设备需求，我们的发展研究计划，并提供了越来越多的灵活性，以进一步研究这些孢子项目和协作，这是对新发现的进一步研究。该头和颈孢子是密歇根大学综合癌症中心的完全整合的组成部分。我们已经大量使用了癌症中心的核心设施以及临床和实验室资源，并大量借鉴了经验丰富的癌症中心领导层。优秀的经验丰富的临床 /基本合作者团队结合了高度机构的承诺和优先级，广泛的患者资源提供了出色的研究环境，可以确保在实现总体孢子目标方面的持续成功。