The Impact of Indoor Particulate Matter Exposure on Non-Allergic Asthma

室内颗粒物暴露对非过敏性哮喘的影响

• 批准号: 7885269
• 负责人: MEREDITH C MCCORMACK
• 金额: $ 19.18万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7885269
• 关键词: Acute; Address; Affect; Air Pollutants; Air Pollution; Airborne Particulate Matter; Allergens; Allergic; American; Area; Asthma; Benzene; Biological Markers; Blood; Blood gas; Breathing; Child; Child health care; Chronic; Clinical; Clinical Investigator; Clinical Research; Data; Data Analyses; Deposition; Disadvantaged; Disease; Employee Strikes; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Monitoring; Epidemiologic Studies; Epidemiology; Equipment; Ethics; Exhalation; Experimental Designs; Exposure to; Extrinsic asthma; Funding; Gases; Goals; Grant; Health; Home environment; Human; Human Resources; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Response; Investigation; Irrigation; Lead; Life; Link; Liquid substance; Lung; Lung diseases; Measurement; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Minority; Modeling; Outcome; Parents; Participant; Particulate; Particulate Matter; Peer Review; Phenotype; Population; Population Study; Predisposition; Prevalence; Principal Investigator; Process; Public Policy; Publishing; Recruitment Activity; Regulation; Relative (related person); Research; Research Design; Research Infrastructure; Research Personnel; Resources; Respiratory physiology; Review Literature; Seasons; Sputum; Symptoms; TNFRSF5 gene; Techniques; Time; Training; Urine; Variant; Vulnerable Populations; airway inflammation; base; comparison group; experience; field study; inner city; mortality; novel therapeutic intervention; outcome forecast; particle; policy implication; pollutant; respiratory; socioeconomics; urban area; young adult

DESCRIPTION (provided by applicant) Asthma is a chronic inflammatory disease of the lungs that is influenced by a combination of host susceptibility and environmental exposures. Particulate air pollution is a pro-inflammatory agent that has been associated with adverse health consequences. While much research has focused on outdoor exposures, the indoor environment is critical as Americans spend most of their time indoors and the investigators' preliminary data have demonstrated that indoor PM concentrations greatly exceed outdoor PM concentrations in urban homes. Based on preliminary data that suggest a strong association between coarse PM exposure and respiratory symptoms among those with non-allergic asthma, the investigators hypothesize that exposure to indoor coarse PM promotes inflammation and worsening of respiratory symptoms and lung function among individuals with non-allergic asthma. Using a study design that combines a longitudinal panel study and an exposure challenge model, the investigators will aim to provide evidence of a causal relationship between indoor coarse PM exposure and exacerbation of asthma status. In specific aim 1, they will determine the effect of indoor coarse PM exposure on asthma health by conducting an epidemiologic panel study measuring in-home PM concentrations and corresponding daily variation in lung function, asthma symptoms, and biomarkers of inflammation among inner-city minority children with non-allergic asthma. In specific aim 2, they will investigate the short-term effects of coarse PM exposure on non-allergic asthma by administering a controlled, nebulized PM challenge and measuring airway reactivity and biomarkers of inflammation. Completion of the proposed research, along with complementary training and mentorship in an outstanding and supportive environment for clinical research, will provide in-depth exposure to clinical research design, conduct, and analysis. These experiences will allow the principal investigator to become a successful, independent investigator in academic medicine. Asthma affects more than 20 million individuals in the U.S, including over 6 million children and young adults. The proposed research investigates the effect of an environmental exposure, air pollution, on this disease process. If indoor exposure to airborne PM triggers asthma exacerbations and stimulates an inflammatory response, the findings from this study may direct new therapeutic interventions and will represent an important advancement in the treatment of asthma with profound public policy implications.

描述（由申请人提供） 哮喘是一种肺部慢性炎症性疾病，受宿主易感性和环境暴露的共同影响。 空气颗粒物污染是一种促炎剂，与不良健康后果有关。 虽然许多研究都集中在室外暴露上，但室内环境至关重要，因为美国人大部分时间都在室内度过，研究人员的初步数据表明，城市家庭中室内 PM 浓度大大超过室外 PM 浓度。 初步数据表明，粗颗粒物接触与非过敏性哮喘患者的呼吸道症状之间存在密切关系，研究人员推测，接触室内粗颗粒物会促进非过敏性哮喘患者的炎症、呼吸道症状和肺功能恶化。 研究人员采用纵向面板研究和暴露挑战模型相结合的研究设计，旨在提供室内粗颗粒物暴露与哮喘状况恶化之间因果关系的证据。 在具体目标 1 中，他们将通过开展一项流行病学小组研究来确定室内粗颗粒物暴露对哮喘健康的影响，该研究测量了市中心少数族裔的家庭 PM 浓度以及肺功能、哮喘症状和炎症生物标志物的相应每日变化。患有非过敏性哮喘的儿童。 在具体目标 2 中，他们将通过实施受控雾化 PM 激发并测量气道反应性和炎症生物标志物来研究粗颗粒 PM 暴露对非过敏性哮喘的短期影响。 完成拟议的研究，并在出色的临床研究支持性环境中提供补充培训和指导，将提供对临床研究设计、实施和分析的深入了解。 这些经验将使主要研究者成为学术医学领域成功的独立研究者。 在美国，哮喘影响着超过 2000 万人，其中包括超过 600 万儿童和年轻人。 拟议的研究调查了环境暴露、空气污染对这种疾病过程的影响。 如果室内暴露于空气中的颗粒物会引发哮喘恶化并刺激炎症反应，那么这项研究的结果可能会指导新的治疗干预措施，并将代表哮喘治疗的重要进展，具有深远的公共政策影响。