Identifying the Neural Basis and Functional Role of Emotional Empathy in Dementia

识别情感同理心在痴呆症中的神经基础和功能作用

基本信息

批准号：
8300539
负责人：
Virginia Emily Sturm
金额：
$ 14.26万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8300539
关键词：
Acoustics Affective Age Aging Altruism Alzheimer&apos s Disease Amygdaloid structure Animal Model Anterior Behavior Behavioral Biological Markers Biological Neural Networks Biological Preservation Brain Brain Stem California Clinical Clinical Data Clinical Research Clip Cognitive Compassion Data Collection Dementia Differential Diagnosis Disease Disease Progression Disease model Electromyography Elements Emotional Emotions Empathy Face Family member Film Foundations Frontotemporal Dementia Functional Magnetic Resonance Imaging Functional disorder Future Goals Human Hypothalamic structure Image Impairment Interdisciplinary Study Knowledge Laboratories Learning Magnetic Resonance Imaging Mammals Measures Medial Mediating Memory Mentored Patient-Oriented Research Career Development Award Mentors Methodology Methods Network-based Neurodegenerative Disorders Neurologist Neurology Neuropsychology Parietal Patients Personality Physiological Process Psychologist Psychophysiology Reaction Research Research Personnel Research Project Grants Rest Role San Francisco Social Functioning Structure Symptoms System Technical Expertise Techniques Testing Training Translations Universities Variant Virginia base behavior measurement career central pattern generator cingulate cortex disorder control drug development emotional stimulus experience gray matter improved informant mimicry neural circuit neuroimaging neuropathology patient oriented pre-clinical research relating to nervous system response social treatment response

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Virginia Sturm, a neuropsychology fellow at the University of California, San Francisco Memory and Aging Center (MAC). Dr. Sturm is establishing herself as a young investigator who conducts patient-oriented clinical research on emotion in neurodegenerative disease. This K23 will provide Dr. Sturm with the support necessary to accomplish the following goals: (1) to gain expertise in neurodegenerative disease, differential diagnosis, and behavioral neurology; (2) to advance her knowledge of psychophysiology by learning a new method, facial electromyography; (3) to become proficient in structural and functional neuroimaging analyses; (4) to obtain experience with clinical measures of real-world behavior; (5) to learn advanced statistical techniques; and (6) to develop an independent research career. To achieve these goals, Dr. Sturm has assembled a mentoring team that includes two primary mentors: Drs. Howard Rosen (a neurologist with expertise in neurodegenerative disease, psychophysiology, and structural neuroimaging) and William Seeley (a neurologist with expertise in neuropathology, functional neuroimaging, and "resting state" network connectivity analyses); two co-mentors: Drs. Bruce Miller (a neurologist with expertise in behavioral neurology, neurodegenerative disease, and clinical research) and Robert Levenson (a psychologist with expertise in psychophysiology, emotion, and empathy); and three consultants: Drs. James Gross (a psychologist with expertise in psychophysiology, facial electromyography, and emotion), John Neuhaus (a biostatistician with expertise in advanced multivariate statistical analyses), [and Gary Glover (an MRI physicist with technical expertise in functional magnetic resonance imaging methodologies)]. The proposed research project focuses on emotional empathy, an automatic affective reaction to others that occurs via physiological and behavioral mirroring mechanisms. Dr. Sturm will use laboratory-based measures of emotion to measure two forms of emotional empathy (i.e., facial mimicry and autonomic reactivity) in patients with behavioral variant frontotemporal dementia (bvFTD), patients with Alzheimer's disease (AD), and healthy control subjects (Aim 1). Dr. Sturm will integrate laboratory measures of emotional empathy with neuroimaging and clinical data in order to identify the neural systems that are related to emotional empathy impairment in bvFTD and preservation in AD (Aim 2) and to determine the real-world behavioral impact of emotional empathy deficits (Aim 3). Data collection will take place at the MAC and at the University of California, Berkeley. [By detailing specific, empathy-relevant, bvFTD-vulnerable neural network, these studies will inform disease models of bvFTD and suggest imaging biomarkers for measuring disease progression and treatment response. Dr. Sturm's K23 training will prepare her to conduct interdisciplinary studies of emotion in neurodegenerative disease and to conduct future studies that detail the neuroanatomical bases of emotional dysfunction in various clinical disorders.] PUBLIC HEALTH RELEVANCE: [A better understanding of the neuroanatomical system that underlies empathic dysfunction will be crucial for improving animal models of behavioral variant front temporal dementia and enhancing drug development efforts in humans by identifying the most relevant brain structures. This information may also improve disease models of other disorders in which socioemotional deficits are a central feature.]

描述（由申请人提供）：这是加州大学旧金山记忆与衰老中心 (MAC) 神经心理学研究员 Virginia Sturm 博士的 K23 奖项申请。 Sturm 博士正在将自己定位为一名年轻的研究者，对神经退行性疾病中的情绪进行以患者为导向的临床研究。此次 K23 将为 Sturm 博士提供实现以下目标所需的支持：（1）获得神经退行性疾病、鉴别诊断和行为神经学方面的专业知识； (2) 通过学习一种新方法——面部肌电图来提高她的心理生理学知识； (3) 精通结构和功能神经影像分析； (4) 获得现实世界行为的临床测量经验；（5）学习先进的统计技术； (6)发展独立的研究事业。为了实现这些目标，Sturm 博士组建了一个指导团队，其中包括两名主要导师： Howard Rosen（一位在神经退行性疾病、心理生理学和结构神经影像学方面具有专业知识的神经学家）和 William Seeley（一位在神经病理学、功能性神经影像学和“静息状态”网络连接分析方面具有专业知识的神经学家）；两位共同导师：博士。布鲁斯·米勒（Bruce Miller）（一位神经学家，在行为神经学、神经退行性疾病和临床研究方面拥有专业知识）和罗伯特·利文森（Robert Levenson）（一位在心理生理学、情感和同理心方面拥有专业知识的心理学家）；和三名顾问：博士。 James Gross（一位在心理生理学、面部肌电图和情感方面具有专业知识的心理学家）、John Neuhaus（一位在高级多元统计分析方面具有专业知识的生物统计学家）和 Gary Glover（一位在功能性磁共振成像方法学方面具有技术专长的 MRI 物理学家）] 。拟议的研究项目侧重于情感同理心，这是通过生理和行为镜像机制对他人产生的自动情感反应。 Sturm 博士将使用基于实验室的情感测量来测量行为变异型额颞叶痴呆 (bvFTD) 患者、阿尔茨海默病 (AD) 患者和健康对照受试者的两种形式的情感同理心（即面部模仿和自主反应）（目标 1）。 Sturm 博士将把情感同理心的实验室测量与神经影像学和临床数据相结合，以确定与 bvFTD 中的情感同理心损伤和 AD 中的情感同理心保留相关的神经系统（目标 2），并确定情感对现实世界行为的影响。同理心缺陷（目标 3）。数据收集将在 MAC 和加州大学伯克利分校进行。 [通过详细描述特定的、与同理心相关的、bvFTD 易受影响的神经网络，这些研究将为 bvFTD 疾病模型提供信息，并建议用于测量疾病进展和治疗反应的成像生物标志物。 Sturm 博士的 K23 培训将使她做好准备，对神经退行性疾病中的情绪进行跨学科研究，并进行未来的研究，详细说明各种临床疾病中情绪功能障碍的神经解剖学基础。] 公共卫生相关性：[更好地了解共情功能障碍背后的神经解剖系统对于改善行为变异性前颞叶痴呆的动物模型以及通过识别最相关的大脑结构来加强人类药物开发工作至关重要。这些信息还可能改善以社会情绪缺陷为核心特征的其他疾病的疾病模型。]