Initiating Substance Use in Adolescence: Associations with rCBF

青春期开始药物使用：与 rCBF 的关联

• 批准号: 8334607
• 负责人: AMY Elizabeth RAMAGE
• 金额: $ 3.74万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334607
• 关键词: Adolescence; Adolescent; Adult; Affect; Age; Alcohol or Other Drugs use; Alcoholism; Alcohols; Base of the Brain; Bass; Behavior; Behavioral; Biological Markers; Blood flow; Brain; Brain region; Caffeine; Cerebrovascular Circulation; Chronic; Clinical; Cognitive; Data; Data Set; Dependence; Development; Doctor of Philosophy; Epidemiology; Exposure to; Future; Genetic; Goals; Health; Image; Magnetic Resonance Imaging; Measures; Mental Depression; Metric; Outcome; Outcome Study; Outcomes Research; Pharmaceutical Preparations; Population; Preparation; Process; Protocols documentation; Public Health; Qualifying; Relative (related person); Reporting; Research; Rest; Risk; Risk-Taking; Sampling; Scanning; Severities; South Texas; Spin Labels; Staging; Structure; Teenagers; Time; Toxin; United States Substance Abuse and Mental Health Services Administration; Work; age group; angiogenesis; base; behavior measurement; brain shape; critical period; follow-up; indexing; meetings; neurodevelopment; neuroimaging; pressure; programs; research study; social; synaptogenesis

DESCRIPTION (provided by applicant): The proposed project will take advantage of the unique opportunity to investigate adolescents prior to or at the early stages of substance use to identify brain-based biomarkers associated with initiation of use, the severity of use and the trajectory of use over time, and the impact of use on the developing brain. The existing, cross- sectional and longitudinal data set (R01AA016274 and ROIMH87493) includes behavioral measures and neuroimaging data for 330 adolescents (age 12-15) at baseline and 264 (age 14-17) at two-year follow-up. Preliminary analyses of ASL-MRI images at baseline using a general index of substance use severity (report of trying two or more substances, SU2+) indicate that resting regional cerebral blood flow to cortico-limbic brain regions is elevated in SU2+ adolescents (n=21) relative to those who were abstinent (n=98). The work proposed will (1) include more qualified severity metrics to clarify associations with rCBF, (2) determine whether baseline cortico-limbic rCBF is associated with future substance use over the two-year clinical follow- up, and (3) the effects of chronic substance use on the developing brain. In addition to the uniqueness and richness of the sample, the focus on resting rCBF is ideal for studying the developing brain as blood flow is required in brain regions where angiogenesis, synaptogenesis or other processes of neurodevelopment are occurring. However, to date quantitative measure of regional cerebral blood flow (rCBF) has been restricted to adult populations. As well, neuroimaging studies of substance use have been limited to adult, chronic users. Therefore, the outcomes produced from this study will be the first reported in this age group, particularly as rCBF relates to substance use.

描述（由申请人提供）：拟议项目将利用这一独特的机会，在物质使用之前或早期阶段对青少年进行调查，以确定与物质使用开始、使用严重程度和物质使用轨迹相关的脑基生物标志物。随着时间的推移使用，以及使用对发育中的大脑的影响。现有的横断面和纵向数据集（R01AA016274 和 ROIMH87493）包括 330 名青少年（12-15 岁）基线和 264 名青少年（14-17 岁）两年随访的行为测量和神经影像数据。使用物质使用严重程度的一般指数（尝试两种或多种物质的报告，SU2+）对基线时的 ASL-MRI 图像进行初步分析表明，SU2+ 青少年中流向皮质边缘脑区域的静息局部脑血流量升高（n=21） ）相对于那些戒酒的人（n=98）。拟议的工作将 (1) 包括更多合格的严重性指标，以阐明与 rCBF 的关联，(2) 确定基线皮质边缘 rCBF 是否与两年临床随访中未来的药物使用相关，以及 (3) 效果长期物质使用对发育中的大脑的影响。除了样本的独特性和丰富性之外，关注静息 rCBF 也是研究发育中大脑的理想选择，因为发生血管生成、突触生成或其他神经发育过程的大脑区域需要血流。然而，迄今为止，局部脑血流量（rCBF）的定量测​​量仅限于成年人群。此外，物质使用的神经影像学研究仅限于成人、长期使用者。因此，本研究的结果将是该年龄组的首次报告，特别是因为 rCBF 与物质使用有关。