Initiating Substance Use in Adolescence: Associations with rCBF

青春期开始药物使用：与 rCBF 的关联

• 批准号: 8334607
• 负责人: AMY Elizabeth RAMAGE
• 金额: $ 3.74万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334607
• 关键词: Adolescence; Adolescent; Adult; Affect; Age; Alcohol or Other Drugs use; Alcoholism; Alcohols; Base of the Brain; Bass; Behavior; Behavioral; Biological Markers; Blood flow; Brain; Brain region; Caffeine; Cerebrovascular Circulation; Chronic; Clinical; Cognitive; Data; Data Set; Dependence; Development; Doctor of Philosophy; Epidemiology; Exposure to; Future; Genetic; Goals; Health; Image; Magnetic Resonance Imaging; Measures; Mental Depression; Metric; Outcome; Outcome Study; Outcomes Research; Pharmaceutical Preparations; Population; Preparation; Process; Protocols documentation; Public Health; Qualifying; Relative (related person); Reporting; Research; Rest; Risk; Risk-Taking; Sampling; Scanning; Severities; South Texas; Spin Labels; Staging; Structure; Teenagers; Time; Toxin; United States Substance Abuse and Mental Health Services Administration; Work; age group; angiogenesis; base; behavior measurement; brain shape; critical period; follow-up; indexing; meetings; neurodevelopment; neuroimaging; pressure; programs; research study; social; synaptogenesis

DESCRIPTION (provided by applicant): The proposed project will take advantage of the unique opportunity to investigate adolescents prior to or at the early stages of substance use to identify brain-based biomarkers associated with initiation of use, the severity of use and the trajectory of use over time, and the impact of use on the developing brain. The existing, cross- sectional and longitudinal data set (R01AA016274 and ROIMH87493) includes behavioral measures and neuroimaging data for 330 adolescents (age 12-15) at baseline and 264 (age 14-17) at two-year follow-up. Preliminary analyses of ASL-MRI images at baseline using a general index of substance use severity (report of trying two or more substances, SU2+) indicate that resting regional cerebral blood flow to cortico-limbic brain regions is elevated in SU2+ adolescents (n=21) relative to those who were abstinent (n=98). The work proposed will (1) include more qualified severity metrics to clarify associations with rCBF, (2) determine whether baseline cortico-limbic rCBF is associated with future substance use over the two-year clinical follow- up, and (3) the effects of chronic substance use on the developing brain. In addition to the uniqueness and richness of the sample, the focus on resting rCBF is ideal for studying the developing brain as blood flow is required in brain regions where angiogenesis, synaptogenesis or other processes of neurodevelopment are occurring. However, to date quantitative measure of regional cerebral blood flow (rCBF) has been restricted to adult populations. As well, neuroimaging studies of substance use have been limited to adult, chronic users. Therefore, the outcomes produced from this study will be the first reported in this age group, particularly as rCBF relates to substance use.

描述（由申请人提供）：拟议的项目将利用独特的机会在物质使用的早期或在物质使用的早期阶段调查青少年，以识别与使用的启动，使用的严重性和随着时间的推移使用的轨迹以及使用对发育脑部的影响。现有的，横断面和纵向数据集（R01AA016274和ROIMH87493）包括在基线时330名青少年（12-15岁）的行为措施和神经成像数据，在两年后随访中为264（年龄14-17）。使用物质使用严重程度的一般指数（尝试两种或多种物质的报告，SU2+）对ASL-MRI图像进行初步分析表明，相对于SU2+青少年（n = 21），静息区域的脑血流升高到皮质中 - limbic大脑区域的升高相对于那些陈述（n = 98）。提出的工作将（1）包括更合格的严重性指标，以阐明与RCBF的关联，（2）确定基线皮质limbic RCBF在两年的临床随访中是否与未来的物质使用有关，并且（3）（3）慢性物质使用对发育发育的大脑的影响。除了样品的独特性和丰富性外，对静止RCBF的关注非常适合研究发育的大脑，因为在发生血管生成，突触发生或其他神经发育过程的大脑区域需要血液流动。然而，迄今为止，区域脑血流（RCBF）的定量度量仅限于成人人群。同样，对药物使用的神经影像学研究仅限于成人，长期使用者。因此，这项研究产生的结果将是该年龄组的首次报道，特别是因为RCBF与药物使用有关。