Enabling Ultra Low Dose PET/CT Imaging

实现超低剂量 PET/CT 成像

基本信息

批准号：
8338782
负责人：
Paul E. Kinahan
金额：
$ 72.37万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-27 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8338782
关键词：
Abdomen Address Adopted Affect Cardiac Clinical Clip Complex Contrast Media Data Detection Development Diagnosis Diagnostic Diagnostic Imaging Dose Electronics Error Sources Evaluation Filtration Financial compensation Goals Image Imaging Techniques Individual Lead Lesion Lung Manufacturer Name Methods Modeling Morphologic artifacts Motion Motivation New Agents Noise Outcome Pathway interactions Patients Phase Photons Physics Physiologic pulse Positron-Emission Tomography Procedures Protocols documentation Radiation Reporting Resolution Sampling Scanning Signal Transduction Staging Techniques Technology Therapy Clinical Trials Tomography, Computed, Scanners Tracer Translations Tube Tumor Volume Variant X-Ray Computed Tomography attenuation base cancer imaging cancer therapy detector image reconstruction improved innovation interest lung imaging novel oncology respiratory response statistics tool treatment planning tumor uptake

项目摘要

DESCRIPTION (provided by applicant): Imaging of cancer with combined positron emission tomography/computed tomography (PET/CT) scanners has become a standard component of oncology diagnosis and staging. Furthermore, quantitative PET/CT is a valuable tool for assessment of an individual's response to therapy and for clinical trials of novel cancer therapies. PET/CT imaging of the lung and abdomen, however, is generally affected by patient respiratory motion, which can lead to underestimation of tracer concentration within a region of interest, overestimation of tumor volume, and mis-matched PET and CT images that yield attenuation correction errors, registration errors and tumor mis-localization. The first source of error (attenuation mismatch) can be addressed by performing CT-based attenuation correction using respiratory gated CT images that are phase-matched with the respiratory gated PET scans. The second source of error (motion blurring) can be addressed by methods using respiratory motion estimation and/or gating. The problem is that even with the lowest possible CT technique, the radiation dose is unacceptably high for diagnostic imaging procedures. Our goal is to reduce CT radiation dose dramatically, while improving PET image by reducing errors introduced by respiratory motion. This will enable more accurate PET/CT imaging by enabling compensation of respiratory motion induced artifacts. This is goal is feasible due to the requirements for the CT component of PET/CT imaging, which are different than those for diagnostic CT. The methods proposed here will (1) reduce radiation dose from CT-based attenuation correction methods and (2) provide routine and high quality compensation of respiratory motion artifacts in PET/CT imaging. This will improve the capabilities of quantitative PET/CT imaging in the development of badly needed therapies for cancer, in the evaluation of response to therapy by for an individual patient, and where lesion uptake is noted is a clinical report. The impact of respiratory motion for detection, a primary tool in diagnosis and staging is not clear, but has also not been properly evaluated yet. In addition, the ultra low dose CT methods developed here may be useful for other applications, such as pulmonary CT imaging, dynamic CT with contrast or new tracers, PET/CT guided radiation treatment planning, and PET/CT cardiac imaging.

描述（由申请人提供）：使用正电子发射断层扫描/计算机断层扫描（PET/CT）组合扫描仪对癌症进行成像已成为肿瘤学诊断和分期的标准组成部分。此外，定量 PET/CT 是评估个体对治疗的反应和新型癌症疗法的临床试验的宝贵工具。然而，肺部和腹部的 PET/CT 成像通常受到患者呼吸运动的影响，这可能导致低估感兴趣区域内的示踪剂浓度、高估肿瘤体积以及导致衰减的 PET 和 CT 图像不匹配校正错误、配准错误和肿瘤错误定位。第一个误差源（衰减不匹配）可以通过使用与呼吸门控 PET 扫描相位匹配的呼吸门控 CT 图像执行基于 CT 的衰减校正来解决。第二个误差源（运动模糊）可以通过使用呼吸运动估计和/或门控的方法来解决。问题是，即使使用尽可能最低的 CT 技术，诊断成像程序的辐射剂量也高得令人无法接受。我们的目标是大幅减少 CT 辐射剂量，同时通过减少呼吸运动引起的误差来改善 PET 图像。这将通过补偿呼吸运动引起的伪影来实现更准确的 PET/CT 成像。由于 PET/CT 成像对 CT 部分的要求与诊断 CT 的要求不同，因此该目标是可行的。这里提出的方法将（1）减少基于 CT 的衰减校正方法的辐射剂量，（2）为 PET/CT 成像中的呼吸运动伪影提供常规和高质量的补偿。这将提高定量 PET/CT 成像的能力，用于开发急需的癌症疗法、评估个体患者对治疗的反应以及临床报告中记录病变的情况。呼吸运动对检测（诊断和分期的主要工具）的影响尚不清楚，但也尚未得到适当评估。此外，这里开发的超低剂量 CT 方法可能适用于其他应用，例如肺部 CT 成像、对比剂或新示踪剂的动态 CT、PET/CT 引导的放射治疗计划和 PET/CT 心脏成像。