Reach Forward: Mechanisms of Practice-Induced Reaching Improvement After Stroke

向前迈进：中风后练习引起的改善机制

基本信息

批准号：
8196883
负责人：
Michelle Lynn Harris-Love
金额：
$ 12.92万
依托单位：
NATIONAL REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-20 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8196883
关键词：
Address Affect Area Brain Brain imaging Data Development Dorsal Equipment Fellowship Fingers Functional Magnetic Resonance Imaging Goals Hand Impairment Individual Institution Intervention Intervention Trial K-Series Research Career Programs Learning Lesion Life Love Measures Mentors Mission Motor Motor Cortex Movement Neuroanatomy Patients Performance Population Postdoctoral Fellow Principal Investigator Recovery Rehabilitation therapy Relative (related person)Research Personnel Research Training Role Severities Step training Stroke Techniques Transcranial magnetic stimulation United States United States National Institutes of Health Upper Extremity Work arm base blood oxygen level dependent burden of illness chronic stroke design disability effective intervention experience improved motor impairment neuromechanism novel post stroke programs relating to nervous system stroke rehabilitation therapy development

项目摘要

DESCRIPTION (provided by applicant): Stroke is the leading cause of long-term disability in the United States. Frequently, stroke results in significant impairment of arm function which contributes heavily to the resulting disability. This proposed project will examine the neural mechanisms of practice-induced improvements in functional arm movements in individuals with chronic stroke, with the broad, long-term objective of reducing stroke-related disability due to arm impairment through novel rehabilitation interventions. The rationale is that knowing the neural bases of post- stroke arm movements is crucial for the development of targeted intervention strategies for those with significant impairment. This project will directly contribute to the NIH mission of reducing "the burdens of illness and disability." The aims of the project are to 1) identify brain areas involved in movement performance of the stroke-affected arm, 2) identify brain areas involved in practice-induced improvements in arm function, and 3) determine whether practice-induced improvements could be enhanced with targeted brain stimulation applied during practice. To address these aims, functional magnetic resonance imaging (fMRI) will be used to measure brain activation during reaching movements in moderately-impaired stroke patients and transcranial magnetic stimulation (TMS) and TMS-fMRI co-registration techniques will be used to upregulate activity in specific brain areas associated with practice-induced performance improvement during practice. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

描述（由申请人提供）：中风是美国长期残疾的主要原因。通常，中风会导致ARM功能的重大损害，从而对由此产生的残疾产生重大贡献。该提议的项目将检查慢性中风患者功能臂运动改善的神经机制，并通过新的康复干预措施通过臂损伤而减少与中风相关的残疾的广泛，长期目标。理由是，了解卒中后运动后运动的神经基础对于为患有重大损害的人制定有针对性的干预策略至关重要。该项目将直接有助于减轻“疾病和残疾负担”的任务。该项目的目的是对1）确定涉及中风影响ARM运动性能的大脑区域，2）确定涉及实践引起的手臂功能改善的大脑区域； 3）确定练习诱导的改善是否可以通过实践中应用的靶向大脑刺激来增强。为了解决这些目的，功能磁共振成像（FMRI）将用于测量在中度受损的中风患者和经颅磁刺激（TMS）（TMS）和TMS-FMRI共同注册技术中，将用于与练习诱导的练习性能提高相关的特定大脑活动的活动。 PHS 398/2590（修订版09/04，重新发行4/2006）页面延续格式页面