Volumetric MRSI Evaluation of Traumatic Brain Injury

创伤性脑损伤的体积 MRSI 评估

基本信息

批准号：
8204443
负责人：
Andrew A. Maudsley
金额：
$ 33.52万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8204443
关键词：
Accounting Affect Age Anisotropy Blast Injuries Brain Brain Concussion Brain Injuries Brain region Choline Clinic Clinical assessments Closed head injuries Cognitive Craniocerebral Trauma Development Diffusion Magnetic Resonance Imaging Evaluation Exhibits Functional disorder Gray unit of radiation dose Head Headache Image Image Analysis Individual Injury Lobar Location Magnetic Resonance Imaging Maps Measurement Measures Membrane Metabolic Metabolic Marker Metabolism Methods Minor N-acetylaspartate Neuronal Dysfunction Neurons Normal Range Outcome Outcome Measure Patients Pattern Performance Post-Concussion Syndrome Post-Traumatic Headaches Protons Public Health Reaction Recovery of Function Relaxation Reporting Severities Signal Transduction Sports Symptoms Testing Time Tissues Traumatic Brain Injury Water base cognitive function expectation follow-up functional outcomes improved magnetic resonance spectroscopic imaging neuroimaging neuropsychological outcome forecast restoration spectroscopic imaging white matter

项目摘要

The primary aim of this project is to develop objective measures for evaluation of mild and moderate Traumatic Brain Injury (MTBI) using advanced MR neuroimaging methods. MTBI represents a major public health problem for which the current assessment measures are limited in their ability to quantify the severity of injury or to indicate possible outcomes. The pilot period of this project has demonstrated that Volumetric Magnetic Resonance Spectroscopic Imaging (MRSI) at 3 Tesla can detect widespread metabolic changes in the brain that correlate with the degree of injury, even for mild injury and in the absence of significant structural MRI findings. It is now proposed to extend this study to improve characterization of these changes and to evaluate the use MRSI and diffusion-weighted MRI measures for prognosis of functional outcomes following mild and moderate closed-head injury. Measurements will include N-Acetylaspartate and choline, metabolic markers known to be sensitive to neuronal dysfunction and membrane turnover, and Fractional Anisotropy, which reflects the degree of neuronal organization. Results will be correlated with findings from structural MRI, initial clinical assessments, and neuropsychological evaluation of functional outcomes at multiple time points after injury. A secondary aim of this study is to examine possible associations between post- concussive symptoms, which are debilitating and persistent consequences in a fraction of this patient group, and neuroimaging measures. A third aim is to optimize the quantitative and multiparametric neuroimaging measures to improve characterization of the spatial extent and the degree of metabolic consequences of the injury, and their associations with functional outcome measures. It is hypothesized that the improved sensitivity and spatial coverage of the proposed neuroimaging measures will improve characterization of mild and moderate injury.

该项目的主要目的是制定客观措施来评估轻度和使用先进的 MR 神经影像方法治疗中度创伤性脑损伤 (MTBI)。 MTBI 是一个重大的公共卫生问题，目前的评估措施是针对该问题的他们量化伤害严重程度或指示可能结果的能力有限。飞行员该项目的周期表明，体积磁共振波谱 3 特斯拉成像 (MRSI) 可以检测到大脑中广泛的代谢变化，这些变化与与损伤程度相关，即使是轻度损伤且没有明显的结构 MRI 发现。现在建议扩展这项研究以改善这些变化的表征并评估 MRSI 和弥散加权 MRI 测量对功能预后的影响轻度和中度闭合性头部损伤后的结果。测量将包括 N-乙酰天冬氨酸和胆碱，已知对神经元功能障碍敏感的代谢标记物和膜周转率，以及分数各向异性，反映神经元的程度组织。结果将与结构 MRI、初始临床的结果相关多个时间点功能结果的评估和神经心理学评估受伤后。本研究的第二个目的是检验术后治疗之间可能存在的关联。脑震荡症状，其中一小部分会导致衰弱和持续的后果患者组和神经影像学测量。第三个目标是优化数量和多参数神经影像测量，以改善空间范围的表征和损伤的代谢后果的程度及其与功能的关联结果措施。据推测，灵敏度和空间覆盖范围的提高拟议的神经影像学措施将改善轻度和中度损伤的特征。