DNA SEQUENCING & ANALYSIS CORE

DNA测序

基本信息

批准号：
8465411
负责人：
HARRY A. DRABKIN
金额：
$ 1.44万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-06 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8465411
关键词：
Alleles Award Biological Assay Blood capillaries Cancer Center Cancer Center Support Grant Cancer cell line Clinical Clinical Sciences Clinical Services Cloning Colorado Computer software Consult Cytogenetics DNA DNA Fingerprinting DNA Sequence DNA Sequence Analysis DNA analysis Development Diagnosis Evaluation Gene Dosage Gene Mutation Genes Human Institution Leadership Ligation Microdissection Modeling Molecular Molecular Cytogenetics Mutation Pathology Process Provider Recording of previous events Research Activity Research Personnel Resource Sharing Resources Services Structure Technology Testing Therapeutic Agents Tissue Banking Tissue Banks Tissues Translational Research Validation Walking anticancer research base biobank capillary design gene function instrument member molecular pathology rapid detection repository response success

项目摘要

The Molecular Pathology Shared Resource (MPSR) represents amalgamation of three existing cores (Cytogenetics, DNA Sequencing, and Pre-analytical Evaluation and Molecular Testing) into a thematically related and operationally coordinated unit. This consolidation creates a seamlessly integrated Shared Resource that mirrors an established CLIA-certified clinical service unit in the Department of Pathology. MPSR will facilitate the development and validation of clinical assays for diagnosis, prognostication, and, most importantly, prediction of response to molecular therapeutic agents for UCCC members. The newly organized Cytogenetics, DNA Sequencing, and Pathology Cores all have a long history within the UCCC. The Cytogenetics Core was started in 1988 and, since 1996, has been under the direction of Dr. Varella-Garcia. The Core began by providing UCCC members access to classical cytogenetic technology and has evolved over the years, in response to the scientific progress in the field, to provide members access to advanced technologies in both classical and molecular cytogenetics. The DNA Sequencing & Analysis Core has enjoyed a similar history, reputation and success. Dr. Korch has been with the (Dore since 1996, first as the manager, and more recently as the Director. The DNA Service is now the major in-state provider of DNA sequencing services to researchers in Colorado, performing basic, translational, and clinical cancer research, including CLIA-certified DNA sequencing services. The Pathology Core was established by Dr. Franklin's predecessor, Dr Gary Miller, in 1986 as one of the founding cores of the UCCC. Over the past 24 years, the core has provided tissue banking and histological services in support of UCCC research activities. Five years ago, lasercapture microdissection services were added to the resource. In 2008, the institution was awarded a clinical and translational sciences award (Colorado Clinical and Translational Sciences Initiative, or CCTSI), under which coordinated biobanking became a priority. Cancer Center leadership used this opportunity to leverage institutional and CCTSI support by consolidating tissue repository services previously under the Pathology Service Core, under the new leadership of Dr. Scott Lucia. This created a new UCCC Tissue Biobanking and Processing Shared Resource (TBP) Shared Resource.

分子病理共享资源（MPSR）代表了三个现有核心（细胞遗传学，DNA测序以及分析前评估和分子测试）的合并，分为主题相关且在操作协调的单元中。这种合并创造了一个无缝集成的共享资源，该资源反映了病理学系已建立的CLIA认证的临床服务部门。 MPSR将促进对诊断，预测，最重要的是，对UCCC成员对分子治疗剂的反应预测的临床测定法的开发和验证。新组织的细胞遗传学，DNA测序和病理核心在UCCC中都有很长的历史。细胞遗传学核心成立于1988年，自1996年以来一直处于Varella-Garcia博士的指导下。核心首先为UCCC成员提供了经典的细胞遗传学技术的访问权，并且多年来，为了响应该领域的科学进步，它已经进化，以使成员可以访问经典和分子细胞遗传学的先进技术。 DNA测序与分析核心也享有相似的历史，声誉和成功。 Korch博士一直在The The The The（自1996年以来，Dore，首先担任经理，最近作为导演。 DNA服务现在是科罗拉多州研究人员的DNA测序服务的主要国家提供商，进行了基本，转化和临床癌症研究，包括CLIA认证的DNA测序服务。病理核心是由富兰克林博士的前任加里·米勒（Gary Miller）博士于1986年建立的，是UCCC的建立核心之一。在过去的24年中，核心提供了组织银行和组织学服务，以支持UCCC研究活动。五年前，Lasercapture 微解剖服务已添加到资源中。 2008年，该机构被授予临床和转化科学奖（科罗拉多州的临床和转化科学计划或CCTSI），根据该奖项，协调生物群成为当务之急。癌症中心领导层利用这一机会来利用机构和CCTSI支持，通过在斯科特·卢西亚（Scott Lucia）博士的新领导下巩固以前在病理服务核心下的组织存储库服务。这创建了一个新的UCCC组织生物群和处理共享资源（TBP）共享资源。