TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGING

通过神经影像追踪 HIV 感染和酒精滥用中枢神经系统合并症

• 批准号: 7722941
• 负责人: Adolf Pfefferbaum
• 金额: $ 1.16万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722941
• 关键词: Alcohol abuse; Alcoholism; Alcohols; Basal Ganglia; Brain; Cerebellum; Choline; Communities; Comorbidity; Computer Retrieval of Information on Scientific Projects Database; Corpus Callosum; Creatine; Disease; Evaluation; Fiber; Funding; Glutamates; Grant; HIV; HIV Infections; Infection; Inositol; Institution; Longitudinal Studies; Modeling; Motor; N-acetylaspartate; Neuropathy; Participant; Phosphocreatine; Physical assessment; Procedures; Protocols documentation; Recruitment Activity; Relaxation; Research; Research Personnel; Resolution; Resources; Sampling; Sensory; Source; Spectrum Analysis; Structure; Study models; Testing; Time; United States National Institutes of Health; cohort; comparison group; falls; frontal lobe; medication compliance; neuroimaging; neuropsychological; research clinical testing; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing a controlled, naturalistic longitudinal study modeling cumulative and progressive effects of HIV infection and alcohol abuse, alone and in combination on brain structure and associated function and are following a sample of community participants who fall into 4 groups: HIV infection along, use disorder alone, HIV combined with AUD, and healthy comparison group without either HIV or AUD. In this continuation cycle we will follow the existing cohort and recruit a new cohort who will also be followed for 3 years. We will enhance the MR protocol with newly developed procedures including a) high resolution, isotropic DTI at 3.0 T for quantitative fiber tracking of selective white matter fiber bundles; b) CT-PRESS spectroscopy to quantify myo-Inositol (mI), glutamate (Glu), N-acetylaspartate (NAA), creatine + phosphocreatine (Cr), and choline (Cho) and calculate the transverse relaxation time (T2) for NAA, Cr and Cho; c) incorporate additional neuropsychological tasks for testing brain structure-function hypotheses; and d) augment clinical evaluation with a physical assessment of neuropathy and formal evaluation of HIV medication compliance. Analyses will test a dual model of the comorbidity of alcohol and HIV: interactive effects on structures disrupted by both diseases (e.g., frontal lobes), additive effects on structures disrupted by only one disease (e.g., basal ganglia in HIV infection, cerebellum in alcoholism), and synergistic effects emerging from disease comorbidity (e.g., motor-sensory sector of the corpus callosum).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们正在继续进行一项受控、自然主义纵向研究，模拟 HIV 感染和酗酒单独或联合对大脑结构和相关功能的累积和渐进影响，并跟踪分为 4 组的社区参与者样本：HIV 感染、酗酒单纯疾病组、HIV 合并 AUD 组、以及没有 HIV 或 AUD 的健康对照组。 在此延续周期中，我们将跟踪现有队列并招募新队列，新队列也将被跟踪 3 年。我们将通过新开发的程序增强 MR 协议，包括 a) 3.0 T 的高分辨率、各向同性 DTI，用于选择性白质纤维束的定量纤维跟踪； b) CT-PRESS 光谱定量肌醇 (mI)、谷氨酸 (Glu)、N-乙酰天冬氨酸 (NAA)、肌酸 + 磷酸肌酸 (Cr) 和胆碱 (Cho)，并计算 NAA 的横向弛豫时间 (T2) 、Cr 和 Cho； c）纳入额外的神经心理学任务来测试大脑结构功能假设； d) 通过对神经病变的身体评估和对 HIV 药物依从性的正式评估来增强临床评估。 分析将测试酒精和艾滋病毒合并症的双重模型：对两种疾病破坏的结构（例如额叶）的交互影响，对仅被一种疾病破坏的结构的附加影响（例如艾滋病毒感染中的基底神经节，酒精中毒中的小脑） ），以及疾病合并症（例如胼胝体的运动感觉部分）产生的协同效应。