WATER DIFFUSION IN CAT BRAIN MEASURED WITH A COMBINED MTC-DWI APPROACH: TOWARDS

使用 MTC-DWI 组合方法测量猫脑中的水扩散：朝向

• 批准号: 7721348
• 负责人: ITAMAR RONEN
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721348
• 关键词: Attenuated; Binding Sites; Brain; Computer Retrieval of Information on Scientific Projects Database; Diffusion weighted imaging; Felis catus; Funding; Grant; Institution; Measures; Molecular Structure; Myelin Sheath; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Water; water diffusion; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, water diffusion in the cat brain was investigated using an approach that combines multidirectional diffusion weighted images (DWI) using multiple b-values, together with magnetization transfer contrast (MTC). The MTC allows attenuate signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在这项研究中，采用将使用多个 b 值的多向扩散加权图像 (DWI) 与磁化传递对比 (MTC) 相结合的方法研究了猫脑中的水扩散。 MTC 可以减弱源自水分子的信号，水分子与大分子结构上的结合位点快速交换，并且在脑白质中，假设 MTC 的很大一部分是由于水与轴突外髓鞘的相互作用所致。