Project B: Mn, DDT/E, PBDE Exposure to Farmworker Children

项目 B：农场工人儿童接触锰、DDT/E、PBDE

• 批准号: 8382014
• 负责人: Asa Bradman
• 金额: $ 14.49万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8382014
• 关键词: 9 year old; Accounting; Address; Affect; Age; Agriculture; Bayesian Method; Biological; Biological Markers; Birth; Blood; Brain; Breast Feeding; California; Characteristics; Chemicals; Child; Childhood; Communities; Cross-Sectional Studies; Data; Data Set; Dental Enamel; Dentin; Development; Diet; Dust; Electronics; Endocrine Disruptors; Enrollment; Environment; Environmental Exposure; Environmental Health; Environmental Wind; Epidemiologic Studies; Exposure to; Family; Farming environment; Flame Retardants; Growth; Health; Health Benefit; Health Care Costs; House Dust; Household; Housing; Incisor; Industrial fungicide; Information Sciences; Laboratories; Latina; Life; Malaria; Maneb; Manganese; Measurable; Measurement; Measures; Metal exposure; Metals; Methods; Metric; Mexican Americans; Mexico; Modeling; Molar tooth; Neurotoxins; Nomads; Nutrient; Organophosphates; Parents; Pattern; Pesticides; Population; Pregnant Women; Puberty; Public Health; Recording of previous events; Reproducibility; Research; Route; Salinum; Sampling; Source; Statistical Models; Supplementation; Technology; Testing; Time; Tooth structure; Umbilical Cord Blood; Urine; Weight; Woman; Work; biobank; boys; cohort; critical period; deciduous tooth; dichlorodiphenyltrichloroethane; drinking water; farm worker; girls; in utero; innovation; innovative technologies; insight; interest; mancozeb; member; neurotoxic; novel; pesticide exposure; phenyl ether; pollutant; postnatal; predictive modeling; pregnant; prenatal; remote sensing; residence; soy; toxicant; trafficking

Children of farmworkers in California are exposed to a unique mix of chemicals, including polybrominated diphenyl ether (PBDE) flame retardants, which are prevalent in California due to the state's strict flammability standards; manganese (Mn), which is a key component of the widely used agricultural fungicides maneb and mancozeb, and the pesticide dichlorodiphenyltrichloroethane (DDT), which was recently used in Mexico where most of their farmworker parents originated. In this proposal, we continue our ongoing research into developing state-of-the-art methods of assessing children's environmental exposures to neurotoxic and endocrine-disrupting compounds and characterizing children's levels, sources, and routes of exposure. We propose to use shed deciduous teeth to develop and validate new biomarkers of prenatal and early postnatal exposure to Mn and will explore whether PBDEs and DDT/E can also be measured in teeth. Using our extensive biorepository of banked prenatal and early postnatal samples, we will determine the relationship between Mn, PBDE, and DDT/E levels in teeth with levels in blood, urine, and breastmilk. We will quantify the sources of children's Mn exposure by measuring levels of Mn in 450 house dust samples collected during the prenatal period and identifying factors that explain these levels, including farmwork of household members, nearby agricultural maneb and mancozeb use, traffic intensity, industrial emissions, and wind patterns. We will examine these factors, as well as diet, in relation to prenatal and early postnatal Mn levels measured in teeth from CHAMACOS children (n=300) and childhood Mn levels measured in blood from CHAMACOS boys collected at age 9 (n=300). We will use innovative GIS methods, remote sensing technology, and Bayesian modeling to build statistical and predictive models of Mn exposure. Finally, we propose to identify population-level correlates of PBDE and DDT/E exposure measured in blood collected from 9-year-old boys (n=300). Factors of interest include diet, breastfeeding history, consumer electronic use, SES, child BMI, time outside the US, household characteristics, and housing quality. This proposal utilizes a rich dataset and biorepository of information on Mexican-American children participating in the CHAMACOS longitudinal birth cohort in the Salinas Valley, California. Novel methods developed under this proposal have the potential to revolutionize our ability to assess prenatal and early postnatal exposures in epidemiologic studies of children's environmental health.

加利福尼亚的农场工人的孩子暴露于独特的化学物质混合物，包括一聚溴 二苯基醚（PBDE）阻燃剂，由于该州严格的易燃性在加利福尼亚州普遍存在 标准；锰（MN），是广泛使用的农业杀菌剂Maneb和 Mancozeb和农药二氯二苯基三氯乙烷（DDT），最近在墨西哥使用 他们的大多数农场工作者父母起源。 在此提案中，我们继续进行持续的研究，以开发评估的最新方法 儿童的环境暴露于神经毒性和内分泌中断的化合物和表征 儿童的水平，来源和接触途径。我们建议使用脱落落叶牙发育和 验证产前和早期产后接触MN的新生物标志物，并将探讨PBDES和PBDES是否是否 DDT/E也可以在牙齿中测量。利用我们广泛的银行产前和早期生物生物措施 产后样本，我们将确定牙齿中Mn，PBDE和DDT/E水平的关系 血液，尿液和母乳的水平。我们将通过测量来量化儿童MN暴露的来源 在产前期间收集的450个房屋灰尘样品中的Mn水平，并确定了这些因素 解释这些级别，包括家庭成员的农场，附近的农业Maneb和Mancozeb 使用，交通强度，工业排放和风模式。我们将研究这些因素以及饮食 关于在Chamacos儿童牙齿中测得的产前和早期产后MN水平（n = 300） 和9岁时收集的Chamacos男孩的血液中的儿童时期水平（n = 300）。我们将使用 创新的GIS方法，遥感技术和贝叶斯建模，以构建统计和 MN暴露的预测模型。最后，我们建议确定PBDE和 DDT/E暴露于9岁男孩收集的血液中（n = 300）。感兴趣的因素包括饮食， 母乳喂养历史，消费者电子使用，SES，儿童BMI，美国以外的时间，家庭 特征和住房质量。 该提案利用有关墨西哥裔儿童的丰富数据集和生物座 参加加利福尼亚州萨利纳斯山谷的Chamacos纵向出生队列。新方法 根据该提案开发的有可能革新我们评估产前和早期的能力 在儿童环境健康的流行病学研究中，产后暴露。