Project B: Mn, DDT/E, PBDE Exposure to Farmworker Children

项目 B：农场工人儿童接触锰、DDT/E、PBDE

• 批准号: 8382014
• 负责人: Asa Bradman
• 金额: $ 14.49万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8382014
• 关键词: 9 year old; Accounting; Address; Affect; Age; Agriculture; Bayesian Method; Biological; Biological Markers; Birth; Blood; Brain; Breast Feeding; California; Characteristics; Chemicals; Child; Childhood; Communities; Cross-Sectional Studies; Data; Data Set; Dental Enamel; Dentin; Development; Diet; Dust; Electronics; Endocrine Disruptors; Enrollment; Environment; Environmental Exposure; Environmental Health; Environmental Wind; Epidemiologic Studies; Exposure to; Family; Farming environment; Flame Retardants; Growth; Health; Health Benefit; Health Care Costs; House Dust; Household; Housing; Incisor; Industrial fungicide; Information Sciences; Laboratories; Latina; Life; Malaria; Maneb; Manganese; Measurable; Measurement; Measures; Metal exposure; Metals; Methods; Metric; Mexican Americans; Mexico; Modeling; Molar tooth; Neurotoxins; Nomads; Nutrient; Organophosphates; Parents; Pattern; Pesticides; Population; Pregnant Women; Puberty; Public Health; Recording of previous events; Reproducibility; Research; Route; Salinum; Sampling; Source; Statistical Models; Supplementation; Technology; Testing; Time; Tooth structure; Umbilical Cord Blood; Urine; Weight; Woman; Work; biobank; boys; cohort; critical period; deciduous tooth; dichlorodiphenyltrichloroethane; drinking water; farm worker; girls; in utero; innovation; innovative technologies; insight; interest; mancozeb; member; neurotoxic; novel; pesticide exposure; phenyl ether; pollutant; postnatal; predictive modeling; pregnant; prenatal; remote sensing; residence; soy; toxicant; trafficking

Children of farmworkers in California are exposed to a unique mix of chemicals, including polybrominated diphenyl ether (PBDE) flame retardants, which are prevalent in California due to the state's strict flammability standards; manganese (Mn), which is a key component of the widely used agricultural fungicides maneb and mancozeb, and the pesticide dichlorodiphenyltrichloroethane (DDT), which was recently used in Mexico where most of their farmworker parents originated. In this proposal, we continue our ongoing research into developing state-of-the-art methods of assessing children's environmental exposures to neurotoxic and endocrine-disrupting compounds and characterizing children's levels, sources, and routes of exposure. We propose to use shed deciduous teeth to develop and validate new biomarkers of prenatal and early postnatal exposure to Mn and will explore whether PBDEs and DDT/E can also be measured in teeth. Using our extensive biorepository of banked prenatal and early postnatal samples, we will determine the relationship between Mn, PBDE, and DDT/E levels in teeth with levels in blood, urine, and breastmilk. We will quantify the sources of children's Mn exposure by measuring levels of Mn in 450 house dust samples collected during the prenatal period and identifying factors that explain these levels, including farmwork of household members, nearby agricultural maneb and mancozeb use, traffic intensity, industrial emissions, and wind patterns. We will examine these factors, as well as diet, in relation to prenatal and early postnatal Mn levels measured in teeth from CHAMACOS children (n=300) and childhood Mn levels measured in blood from CHAMACOS boys collected at age 9 (n=300). We will use innovative GIS methods, remote sensing technology, and Bayesian modeling to build statistical and predictive models of Mn exposure. Finally, we propose to identify population-level correlates of PBDE and DDT/E exposure measured in blood collected from 9-year-old boys (n=300). Factors of interest include diet, breastfeeding history, consumer electronic use, SES, child BMI, time outside the US, household characteristics, and housing quality. This proposal utilizes a rich dataset and biorepository of information on Mexican-American children participating in the CHAMACOS longitudinal birth cohort in the Salinas Valley, California. Novel methods developed under this proposal have the potential to revolutionize our ability to assess prenatal and early postnatal exposures in epidemiologic studies of children's environmental health.

加利福尼亚州农场工人的孩子接触到独特的化学物质混合物，包括多溴化物 二苯醚（PBDE）阻燃剂，由于该州严格的可燃性，这种阻燃剂在加州很流行 标准；锰 (Mn)，是广泛使用的农业杀菌剂代森锰和 代森锰锌，以及最近在墨西哥使用的杀虫剂二氯二苯基三氯乙烷 (DDT) 他们大多数农场工人的父母都来自那里。 在本提案中，我们继续研究开发最先进的评估方法 儿童在环境中暴露于神经毒性和内分泌干扰化合物的情况并表征 儿童的水平、来源和接触途径。我们建议利用脱落的乳牙来发育和 验证产前和产后早期接触锰的新生物标志物，并将探讨多溴联苯醚和 DDT/E 也可以在牙齿中测量。使用我们广泛的产前和早期生物储存库 产后样本中，我们将确定牙齿中 Mn、PBDE 和 DDT/E 水平之间的关系 血液、尿液和母乳中的含量。我们将通过测量来量化儿童锰暴露的来源 产前期间收集的 450 个室内灰尘样本中的锰含量，并确定影响因素 解释这些水平，包括家庭成员的农活、附近的农业代森锰和代森锰锌 使用、交通强度、工业排放和风型。我们将检查这些因素以及饮食， 与 CHAMACOS 儿童牙齿中测量的产前和产后早期锰水平相关 (n=300) 9 岁时采集的 CHAMACOS 男孩血液中测量的儿童期锰水平 (n=300)。我们将使用 创新的 GIS 方法、遥感技术和贝叶斯建模来构建统计和 锰暴露的预测模型。最后，我们建议确定 PBDE 和 PBDE 的人口水平相关性 从 9 岁男孩 (n=300) 采集的血液中测量 DDT/E 暴露量。感兴趣的因素包括饮食、 母乳喂养史、消费电子产品使用情况、SES、儿童 BMI、在美国境外的时间、家庭 特点和住房质量。 该提案利用了有关墨西哥裔美国儿童的丰富数据集和生物信息库 参加加利福尼亚州萨利纳斯谷的 CHAMACOS 纵向出生队列。新方法 根据该提案开发的产品有可能彻底改变我们评估产前和早期的能力 儿童环境健康流行病学研究中的产后暴露。