A SYSTEM TO SHARE AND EXPLORE HUMAN BRAIN MAPPING DATA

共享和探索人脑图谱数据的系统

• 批准号: 7724323
• 负责人: KEN SMITH
• 金额: $ 0.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724323
• 关键词: Architecture; Area; Brain; Brain Mapping; Brain region; Communication; Communities; Compatible; Computer Retrieval of Information on Scientific Projects Database; Creativeness; Data; Data Set; Databases; Development; Funding; Grant; Human; Imaging technology; Informatics; Information Management; Institution; International; Laboratories; Language; Magnetic Resonance Imaging; Management Information Systems; Neurosciences; Numbers; Policies; Population; Productivity; Research; Research Personnel; Resources; Sampling; Source; Structure; System; Techniques; Testing; United States National Institutes of Health; Vision; data modeling; design; innovation; interest; neuroinformatics; open source; peer; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent advances in imaging technologies have provided human brain mapping researchers with awide repertoire of experimental approaches to elucidate brain structure and function at a variety of spatial scales. Over the entire neuroscience community, a vast amount of human brain mapping data is being gathered. However, lack of suitable a information management system keeps the value and scientific impact of this data from reaching its full potential, as it is explored almost exclusively by the lab of origin using data and resources which are locally accessible. We envision a worldwide information management network capable of increasing the creativity and productivity of neuroscience investigators, as they use shared human brain mapping data to generate and test ideas that were unanticipated by the data's originators. To achieve this vision, we propose to design an open source information management system that enables the exploration, analysis, and controlled sharing of structural magnetic resonance imaging (MRI) data. This system will function flexibly in multiple modes: as an international repository and data exploration platform for the neuroscience community, as part of a peer-to-peer sharing network, or as a lightweight stand-alone laboratory information management system. We expect that increased creativity and productivity will derive from the ability to: 1) access a large number of MRI datasets that sample a broad demographic spectrum; 2) query by example (e.g. "retrieve volumes which look like this example") and over specific brain region attributes (e.g., volume) to generate and test neuroscientific hypotheses; 3) create, visualize, and manipulate average brain representations tailored to a demographic population of interest; and 4) rely on a common set of basic terms and sharing principles to faciliate communication in peer relationships. The system's design will entail the development of innovative informatics techniques in the areas of data modeling, query languages, and systems architecture. It will be scalable in size, extensible in capabilities, flexible in data sharing policy options, and compatible in format with other neuroinformatic systems.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 成像技术的最新进展为人类大脑绘图研究人员提供了广泛的实验方法，以阐明各种空间尺度的大脑结构和功能。在整个神经科学界，大量的人脑图谱数据正在被收集。然而，缺乏合适的信息管理系统使这些数据的价值和科学影响无法充分发挥其潜力，因为这些数据几乎完全由原始实验室使用本地可访问的数据和资源进行探索。我们设想一个全球信息管理网络能够提高神经科学研究人员的创造力和生产力，因为他们使用共享的人脑映射数据来生成和测试数据发起者未预料到的想法。为了实现这一愿景，我们建议设计一个开源信息管理系统，能够对结构磁共振成像（MRI）数据进行探索、分析和受控共享。该系统将以多种模式灵活运行：作为神经科学界的国际存储库和数据探索平台，作为点对点共享网络的一部分，或作为轻量级独立实验室信息管理系统。我们预计创造力和生产力的提高将源自以下能力：1）访问对广泛的人口统计范围进行采样的大量 MRI 数据集； 2）通过示例查询（例如“检索与此示例类似的体积”）和特定大脑区域属性（例如体积）以生成和测试神经科学假设； 3）创建、可视化和操纵针对感兴趣的人口统计人群量身定制的平均大脑表征； 4) 依靠一套通用的基本术语和共享原则来促进同伴关系中的沟通。该系统的设计将需要在数据建模、查询语言和系统架构领域开发创新信息学技术。它将在规模上可扩展，在功能上可扩展，在数据共享策略选项上灵活，并且在格式上与其他神经信息系统兼容。