Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

外观和性能增强药物使用的生物行为后果

• 批准号: 8269936
• 负责人: THOMAS B HILDEBRANDT
• 金额: $ 17.7万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8269936
• 关键词: Adult; Age; Aggressive behavior; Aminobutyric Acids; Anabolic steroids; Appearance; Area; Argipressin; Athletic; Behavior; Behavioral; Biological; Characteristics; Clinical; Clinical Research; Data; Dependence; Development; Disease; Drug usage; Drug user; Eating; Education; Educational Background; Endocrine; Environment; Ethical Issues; Ethics; Exercise; Fatty acid glycerol esters; Functional disorder; Funding; Goals; Growth; Hormonal; Hormones; Impulsivity; Individual; K-Series Research Career Programs; Knowledge; Learning; Legal; Licensing; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Medical; Metabolic; Methodology; Mission; Modeling; Moods; Muscle; Nandrolone; Neuroendocrinology; Neurosecretory Systems; Neurotransmitters; Pattern; Performance; Personality; Pharmaceutical Preparations; Policies; Preventive Intervention; Psychiatry; Public Health; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Scientist; Serotonin; Substance abuse problem; System; Testosterone; Time; Training; Translational Research; Weight; Work; adverse outcome; base; behavior change; career; clinically significant; data modeling; design; disturbance in affect; experience; falls; improved; interest; male; medical schools; patient oriented; professor; programs; response; self esteem; skills; social; theories; Adult; Age; Aggressive behavior; Aminobutyric Acids; Anabolic steroids; Appearance; Area; Argipressin; Athletic; Behavior; Behavioral; Biological; Characteristics; Clinical; Clinical Research; Data; Dependence; Development; Disease; Drug usage; Drug user; Eating; Education; Educational Background; Endocrine; Environment; Ethical Issues; Ethics; Exercise; Fatty acid glycerol esters; Functional disorder; Funding; Goals; Growth; Hormonal; Hormones; Impulsivity; Individual; K-Series Research Career Programs; Knowledge; Learning; Legal; Licensing; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Medical; Metabolic; Methodology; Mission; Modeling; Moods; Muscle; Nandrolone; Neuroendocrinology; Neurosecretory Systems; Neurotransmitters; Pattern; Performance; Personality; Pharmaceutical Preparations; Policies; Preventive Intervention; Psychiatry; Public Health; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Scientist; Serotonin; Substance abuse problem; System; Testosterone; Time; Training; Translational Research; Weight; Work; adverse outcome; base; behavior change; career; clinically significant; data modeling; design; disturbance in affect; experience; falls; improved; interest; male; medical schools; patient oriented; professor; programs; response; self esteem; skills; social; theories

The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Dsychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and agression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.

拟议的K23面向患者职业发展奖旨在为PI提供 研究外观生物行为后果的个人变异性所必需的培训 性能增强药物（APED）的使用。候选人：PI是助理教授和许可临床 目前在西奈山医学院（MSSM）的饮食和体重 疾病程序。他计划使用K23成为R01资助的研究人员，与之紧密合作 APED使用提出的临床，道德和科学挑战的基本和转化科学家。在 为了获得这些职业目标，他将使用K23来获得知识，技能和能力 该研究的内分泌/神经内分泌功能与侵蚀/冲动之间的关系 APED用户。他的具体培训目标是（a）学习理论，方法论和临床 研究APED使用的病理和非病理形式之间的区别的方法，（b） 通过转化研究来发展有关理论和方法的工作知识 研究激素行为关系，（c）获得有关激素的理论和方法的专业知识 对精神病的失调，（d）对医学，法律和道德的更多了解 与研究药物滥用相关的问题，以及（e）在纵向数据建模和 生物数据的统计分析。环境：PI提出的培训计划和职业目标是 与MSSM精神病学系的任务声明一致，以整合翻译和 临床研究，特别是在神经内分泌学领域。希尔德布兰德博士为他提供了 可用的丰富专业知识和资源（包括实验室）促进了研究两种内分泌的必要条件 和神经内分泌功能。研究：对APED使用的最可靠的精神病结果是 尽管已经观察到了一系列精神病障碍，但冲动性侵略性增加。这 监督研究项目将是对激素和精神病学程度的纵向研究 跨时间（周期和周期）的60名成年男性aped用户的失调（侵略性和冲动性）（侵略性和冲动性） 与20岁，锻炼和教育相匹配的控制。分段潜在的生长曲线建模将 用于研究周期和周期变化的变化，以下变化的预测指标将为 探索：APED特征（数量，持续时间和模式），年龄，精神病史，个性和 APED使用的历史）。相关性：拟议研究的发现将有助于识别内分泌 功能障碍负责对APED使用的精神科后果和用户特征 预测这些精神科后果。这项研究的含义是为预防提供信息， 干预措施和基于政策的决策与这种日益增长的公共卫生有关。