Clinical validation of cardiac strain measures with real-time 4D ultrasound

使用实时 4D 超声测量心脏应变的临床验证

• 批准号: 7528866
• 负责人: Andrew Francis Laine
• 金额: $ 47.29万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7528866
• 关键词: Algorithms; Arts; Biomechanics; Biomedical Engineering; Canis familiaris; Cardiac; Cardiac Catheterization Procedures; Clinical; Clinical Research; Collaborations; Complex; Confined Spaces; Congenital Heart Defects; Data; Data Set; Development; Echocardiography; Endocardium; Epicardium; Evaluation Studies; Exercise stress test; Four-Dimensional Echocardiography; Four-dimensional; Goals; Gold; Heart; Image; Imagination; Imaging Techniques; Imaging technology; Implant; Invasive; Ischemia; Laboratories; Magnetic Resonance Imaging; Manuals; Measurement; Measures; Medicine; Methods; Metric; Monitor; Motion; Myocardial; Myocardium; Optics; Patients; Performance; Phase; Population; Post Technic; Procedures; Process; Public Health; Quantitative Evaluations; Range; Research; Risk; Screening procedure; Staging; Standards of Weights and Measures; Techniques; Technology; Testing; Three-Dimensional Image; Time; Tissues; Today; Torsion; Two-Dimensional Echocardiography; Ultrasonography; Universities; Validation; Work; base; bioimaging; cardiography; clinical Diagnosis; clinical application; design; diabetic cardiomyopathy; evaluation/testing; healthy volunteer; heart imaging; heart motion; improved; in vivo; new technology; novel; research clinical testing; tool; validation studies

DESCRIPTION (provided by applicant): Technology for imaging the heart has advanced dramatically in recent years. In particular, real-time three-dimensional ultrasound (RT3D or 4D) has captured the imagination of cardiologists with its ability to obtain complete three-dimensional images of the heart over an entire cardiac cycle in just a few seconds of imaging. The complex cardiac wall motion and temporal information contained in these four-dimensional (3D + time) data sequences has the potential to greatly enhance clinical diagnoses of the heart. However, most cardiac examination centers still depend on 2D echocardiography, and the temporal information in the 4D cardiac imaging is often overlooked. The goal of this proposal is to utilize the wealth of information contained in 4D ultrasound. In particular, this proposal will focus on a common problem for which 4D cardiac imaging is ideally suited: measuring strain and cardiac torsion directly from 4D ultrasound. The aims of this proposal are: (1) Quantify errors of displacement and strain from optical flow on 4D ultrasound with respect to results obtained by sonomicrometry implanted in dog hearts; (2) Test the hypothesis that optical flow on 4D ultrasound can have clinically equivalent results on healthy volunteers (normal hearts) and diseased hearts compared to similar measures of strain obtained by MRI based methods; (3) Test the hypothesis that optical flow on 4D ultrasound has specific advantages in terms of performance over existing 2D based methods of strain estimation. The design of our method is based on optical flow to track myocardial motion in 4D ultrasound. Directional displacements and strains and cardiac torsion can be automatically derived from the 3D + time motion field estimated. In aims 1 and 2, specific displacements, strains, and torsion will be measured and compared to "gold standards" in quantitative evaluation studies. In aim 3, we will extensively compare the performance of 4D methods and 2D methods in estimating strain measures across a wide range of clinical echocardiography patient data sets. Once completed, the questions of why and when to best use 4D rather then 2D measures will be answered quantitatively. PUBLIC HEALTH RELEVANCE: The significance of the proposed work is that it will provide a novel and effective 3D strain and torsion measuring tool, allowing clinicians to routinely measure wall motion quantitatively and in real-time. In addition this research will provide cardiologists with improved screening tests for diabetic cardiomyopathy (and dyssynchrony) to help them determine those patients that may require more invasive and costly procedures such as heart catheterization from patients that can be safely spared such tests.

描述（由申请人提供）：近年来，心脏成像技术取得了巨大进步。特别是，实时三维超声（RT3D 或 4D）能够在短短几秒钟的成像时间内获得整个心动周期的完整心脏三维图像，从而激发了心脏病专家的想象力。这些四维（3D + 时间）数据序列中包含的复杂心脏壁运动和时间信息有可能极大地增强心脏的临床诊断。然而，大多数心脏检查中心仍然依赖2D超声心动图，而4D心脏成像中的时间信息常常被忽视。该提案的目标是利用 4D 超声中包含的丰富信息。特别是，该提案将重点关注 4D 心脏成像非常适合的常见问题：直接从 4D 超声测量应变和心脏扭转。该提案的目的是：（1）根据植入狗心脏的声测法获得的结果，量化 4D 超声光流的位移和应变误差； (2) 检验以下假设：与基于 MRI 的方法获得的类似应变测量结果相比，4D 超声光流可以对健康志愿者（正常心脏）和患病心脏产生临床上相同的结果； (3) 测试 4D 超声光流在性能方面比现有基于 2D 的应变估计方法具有特定优势的假设。我们的方法的设计基于光流来跟踪 4D 超声中的心肌运动。定向位移和应变以及心脏扭转可以从估计的 3D + 时间运动场自动导出。在目标 1 和 2 中，将测量特定的位移、应变和扭转，并与定量评估研究中的“黄金标准”进行比较。在目标 3 中，我们将广泛比较 4D 方法和 2D 方法在估计各种临床超声心动图患者数据集的应变测量方面的性能。一旦完成，为什么以及何时最好使用 4D 而不是 2D 测量的问题将得到定量答案。 公共健康相关性：拟议工作的意义在于，它将提供一种新颖有效的 3D 应变和扭转测量工具，使临床医生能够定期定量、实时测量室壁运动。此外，这项研究将为心脏病专家提供改进的糖尿病心肌病（和不同步）筛查测试，帮助他们确定哪些患者可能需要更具侵入性和成本更高的手术，例如可以安全地免除此类测试的患者的心导管插入术。