The Distinct Role of CBP and p300 in Regulating Hepatic Glucose Production

CBP 和 p300 在调节肝葡萄糖生成中的独特作用

• 批准号: 8310339
• 负责人: Ling He
• 金额: $ 24.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8310339
• 关键词: Acetylation; Adult; Affect; Animals; Antidiabetic Drugs; Award; Binding; Blood; Blood Glucose; CREB1 gene; Cell Line; Cells; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Development; Diabetes Mellitus; Diet; Direct Costs; EP300 gene; Enzyme Gene; Enzymes; Exhibits; Facilities and Administrative Costs; Fasting; Fatty acid glycerol esters; Forskolin; Gene Expression; Gene Expression Profile; Genes; Glucagon; Gluconeogenesis; Glucose; Goals; Health; Hepatic; Hepatocyte; Hyperglycemia; Individual; Insulin; Insulin Resistance; Knockout Mice; Liver; Mediating; Mediator of activation protein; Mentors; Metformin; Modality; Morbidity - disease rate; Mus; Mutant Strains Mice; Mutation; Newly Diagnosed; Non-Insulin-Dependent Diabetes Mellitus; Okadaic Acid; Pancreas; Patients; Phase; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiological; Prevalence; Protein Dephosphorylation; Protein phosphatase; Regulation; Relative (related person); Role; Serine; Signal Pathway; Site; Societies; Testing; Transcriptional Regulation; United States; Up-Regulation; calyculin A; feeding; glucose production; hepatic gluconeogenesis; hepatoma cell; insulin signaling; lipid biosynthesis; mortality; mutant mouse model; programs; reconstitution; small hairpin RNA; Acetylation; Adult; Affect; Animals; Antidiabetic Drugs; Award; Binding; Blood; Blood Glucose; CREB1 gene; Cell Line; Cells; Complex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Data; Development; Diabetes Mellitus; Diet; Direct Costs; EP300 gene; Enzyme Gene; Enzymes; Exhibits; Facilities and Administrative Costs; Fasting; Fatty acid glycerol esters; Forskolin; Gene Expression; Gene Expression Profile; Genes; Glucagon; Gluconeogenesis; Glucose; Goals; Health; Hepatic; Hepatocyte; Hyperglycemia; Individual; Insulin; Insulin Resistance; Knockout Mice; Liver; Mediating; Mediator of activation protein; Mentors; Metformin; Modality; Morbidity - disease rate; Mus; Mutant Strains Mice; Mutation; Newly Diagnosed; Non-Insulin-Dependent Diabetes Mellitus; Okadaic Acid; Pancreas; Patients; Phase; Phenotype; Phosphorylation; Phosphorylation Site; Phosphotransferases; Physiological; Prevalence; Protein Dephosphorylation; Protein phosphatase; Regulation; Relative (related person); Role; Serine; Signal Pathway; Site; Societies; Testing; Transcriptional Regulation; United States; Up-Regulation; calyculin A; feeding; glucose production; hepatic gluconeogenesis; hepatoma cell; insulin signaling; lipid biosynthesis; mortality; mutant mouse model; programs; reconstitution; small hairpin RNA

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