Chemistry & Biology of Tetrapyroles 2008 Gordon Research Conference

化学

• 批准号: 7540854
• 负责人: Judith N Burstyn
• 金额: $ 1.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7540854
• 关键词: Address; Agriculture; Anemia; Area; Biological; Biology; Blood; Cells; Chemicals; Chemistry; Communicable Diseases; Communities; Development; Discipline; Disease; Fertilization; Funding; Generations; Goals; Heme; Human body; Inborn Genetic Diseases; Malaria; Medical; Metabolism; Mitochondrial Diseases; Participant; Pathway interactions; Pernicious Anemia; Pigments; Plants; Porphyrias; Research; Role; Signal Transduction; Stroke; Tetrapyrroles; Vascular Diseases; Vitamin B 12; abstracting; design; frontier; human disease; interest; novel; programs; symposium; trafficking

DESCRIPTION (Provided by applicant): This proposal specifically requests funding to support the 2008 conference on Chemistry & Biology of Tetrapyrroles. This intimate meeting, which is limited to 135 participants, is unique: there is no other meeting of the tetrapyrrole research community with a similar tradition of such broad disciplinary participation. The program will focus on new frontiers including tetrapyrroles in energy generation in plants and in solar cells, emerging roles for tetrapyrroles in cell signaling and human disease, tetrapyrrole trafficking, and novel pathways, both biological and synthetic, to elaborated tetrapyrroles. The meeting will highlight key areas of progress in the field in which the chemistry and biology inform new medical, agricultural and technological developments, with each session designed to cut across the disciplines represented among the participants. This proposal will address three specific aims: 1) to organize an interdisciplinary meeting in which each session cuts across the disciplines represented among our participants, in order that the latest chemistry and biology may be viewed in the context of the medical, agricultural or technological context in which it is relevant, 2) to encourage interaction among participants from differing disciplines in order to facilitate the best possible scientific exchange and to nourish the field of tetrapyrrole chemistry & biology through cross- fertilization, 3) to reignite interest among the medical and chemical communities in this meeting. To accomplish these goals we have selected an outstanding group of speakers and discussion leaders who represent the cutting edge of the field. Among the medical topics to be covered include: the role of heme metabolism in parasitic and bacterial infectious disease, vascular disease, and mitochondrial disease; the interplay of heme and B12 in pernicious anemia; and inborn errors of tetrapyrrole synthesis, trafficking and degradation. This meeting will explore the frontiers of understanding about how heme, the pigment that makes your blood red, vitamin B12, and other related molecules function in the human body. Important new research will be presented on how these colorful molecules are involved in diseases like malaria, anemia, stroke and porphyria. (End of Abstract)

描述（由申请人提供）： 该提案特别请求资金支持 2008 年四吡咯化学与生物学会议。这次仅限 135 名参与者的亲密会议是独一无二的：四吡咯研究界没有其他会议具有如此广泛的学科参与的类似传统。该计划将重点关注新领域，包括四吡咯在植物和太阳能电池中的能源产生、四吡咯在细胞信号传导和人类疾病中的新作用、四吡咯运输以及精制四吡咯的生物和合成新途径。会议将重点介绍化学和生物学领域的关键进展领域，其中化学和生物学为新的医学、农业和技术发展提供信息，每场会议都旨在跨越与会者所代表的学科。该提案将解决三个具体目标：1）组织一次跨学科会议，其中每场会议都跨越参与者所代表的学科，以便可以在医学、农业或技术背景下看待最新的化学和生物学2) 鼓励来自不同学科的参与者之间的互动，以促进尽可能最好的科学交流，并通过交叉授精来滋养四吡咯化学和生物学领域，3) 重新激发医学和化学领域的兴趣在此社区 会议。为了实现这些目标，我们选择了一群代表该领域前沿的杰出演讲者和讨论领袖。涵盖的医学主题包括：血红素代谢在寄生虫和细菌传染病、血管疾病和线粒体疾病中的作用；血红素和 B12 在恶性贫血中的相互作用；以及四吡咯合成、运输和降解的先天性错误。本次会议将探讨血红素（使血液呈红色的色素）、维生素 B12 和其他相关分子如何在人体内发挥作用的前沿知识。关于这些彩色分子如何参与疟疾、贫血、中风和卟啉症等疾病的重要新研究将被提出。 （摘要完）