Wear Analysis of Intervertebral Total Disc Replacements

全椎间盘置换术的磨损分析

• 批准号: 7811049
• 负责人: THOMAS DUDLEY BROWN
• 金额: $ 21.61万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7811049
• 关键词: Accounting; Area; Behavior; Biological Preservation; Biomedical Engineering; Caliber; Calibration; Charities; Classification; Clinical; Communities; Complex; Complication; Computer Simulation; Couples; Data; Dependency; Devices; Drug Formulations; Equipment; Europe; Exhibits; Face; Failure; Funding; Future; Goals; Implant; Joints; Kinetics; Lubrication; Measurement; Mechanics; Metals; Methodology; Modeling; Motion; Operative Surgical Procedures; Parents; Pattern; Phase; Polyethylenes; Process; Protocols documentation; Recovery; Research; Resources; Running; Series; Solid; Speed; Spinal Cord; Surface; Surgeon; Techniques; Testing; United States National Institutes of Health; Vertebral column; Work; abstracting; base; design; engineering design; experience; improved; in vivo; interest; intervertebral disk degeneration; kinematics; novel; parent grant; patient population; pre-clinical; pressure; public health relevance; research study; simulation

DESCRIPTION (provided by applicant): Project Summary/Abstract Intervertebral total disc replacement (TDR) implants potentially herald a paradigm shift in the management of degenerative disc disease. Preservation of motion may avoid adjacent-segment degeneration, a well- recognized complication of fusion. Based on encouraging experience in Europe and subsequent FDA approvals in 2004 and 2005, the Charity III and ProDisc TDR devices have come into clinical use by many spine surgeons in the US. As an alternative to fusion (~300,000/year in the U.S.), there is substantial interest in increasingly wide usage of this class of devices. However, the potential for late wear-related complications is disconcerting. Both Chariti and ProDisc involve metal-on-conventional-polyethylene bearings, and the TDR patient population is a decade younger than for THR/TKR. Moreover, owing to close proximity of the spinal cord, the potential consequences of implant failure are substantially more dire than for THR/TKR. It is crucial that the scientific community expeditiously confront the issue of TDR wear. A Bioengineering Research Partnership supported by the parent grant is working to provide a firm scientific basis for identifying and dealing with wear-related problems in TDR. This parent grant research (Notice Number NOT-OD-09-058 titled NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications) involves developing techniques for TDR wear assessment in the pre-clinical phase (Aim 1), implementing a novel technique for in vivo TDR radiographic wear measurement (Aim 2), and assessing the functional biologic activity of TDR wear debris (Aim 3). A revision to the parent grant is proposed to expand and improve upon the computational wear simulation aspects under study in parent Specific Aim 1. The goal of the proposed revision research is to identify methodology by means of which the experimentally-sourced tribologic wear factors used in TDR computational wear simulations can be realistically determined from independently conducted pin-on- plate wear tests, to avoid the need for calibration/linkage to already-performed TDR physical wear simulations. This will open the way to expedited computational simulations of substantively different TDR designs, and to testing of novel hypotheses related to TDR wear, that otherwise would not be possible. PUBLIC HEALTH RELEVANCE: Project Narrative Relevance: Computer simulation of the wear of total disc replacement implants has great usefulness both for engineering design purposes and for surgical assessments. Revision research is proposed for ways to make these computer simulations more accurate and more versatile, by means of better accuracy of one of the key pieces of experimental information (known as the wear factor) needed as input information for these simulations.

描述（由申请人提供）：项目摘要/摘要椎间盘全椎间盘置换（TDR）植入物可能预示着退行性椎间盘疾病治疗的范式转变。保留运动可以避免相邻节段退化，这是一种公认​​的融合并发症。基于欧洲令人鼓舞的经验以及随后 2004 年和 2005 年 FDA 的批准，Charity III 和 ProDisc TDR 设备已被美国许多脊柱外科医生投入临床使用。作为聚变的替代方案（美国每年约 300,000 个），人们对此类设备的日益广泛使用产生了浓厚的兴趣。然而，后期磨损相关并发症的可能性令人不安。 Chariti 和 ProDisc 均采用金属对传统聚乙烯轴承，TDR 患者群体比 THR/TKR 患者年轻十年。此外，由于靠近脊髓，植入失败的潜在后果比 THR/TKR 更为严重。科学界迅速应对 TDR 磨损问题至关重要。由母公司拨款支持的生物工程研究合作伙伴关系正在努力为识别和处理 TDR 中的磨损相关问题提供坚实的科学基础。这项家长资助研究（通知号 NOT-OD-09-058，标题为 NIH 宣布恢复法案基金用于竞争性修订申请的可用性）涉及开发临床前阶段 TDR 磨损评估技术（目标 1），实施一项新技术用于体内 TDR 射线磨损测量（目标 2），并评估 TDR 磨损碎片的功能生物活性（目标 3）。建议对父资助进行修订，以扩展和改进父具体目标 1 中正在研究的计算磨损模拟方面。拟议修订研究的目标是确定方法，通过该方法，在TDR 计算磨损模拟可以根据独立进行的销盘磨损测试实际确定，以避免校准/链接到已执行的 TDR 物理磨损模拟。这将为加速实质上不同的 TDR 设计的计算模拟以及测试与 TDR 磨损相关的新假设开辟道路，否则这是不可能的。 公共健康相关性：项目叙述相关性：全椎间盘置换植入物磨损的计算机模拟对于工程设计目的和手术评估都非常有用。提出了修订研究，通过提高作为这些模拟的输入信息所需的关键实验信息之一（称为磨损系数）的准确性，使这些计算机模拟更加准确和通用。

项目成果

The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement.

• DOI: 10.1097/brs.0b013e31823cbd6e
• 发表时间: 2012-04-20
• 期刊: Spine
• 影响因子: 3
• 作者: Vicars R;Prokopovich P;Brown TD;Tipper JL;Ingham E;Fisher J;Hall RM
• 通讯作者: Hall RM

Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells

• DOI: 10.1016/j.biomaterials.2013.01.023
• 发表时间: 2013-05-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Behl, Bharat;Papageorgiou, Iraklis;Ingham, Eileen
• 通讯作者: Ingham, Eileen

Cross-shear implementation in sliding-distance-coupled finite element analysis of wear in metal-on-polyethylene total joint arthroplasty: intervertebral total disc replacement as an illustrative application.

• DOI: 10.1016/j.jbiomech.2010.03.003
• 发表时间: 2010-06-18
• 期刊: JOURNAL OF BIOMECHANICS
• 影响因子: 2.4
• 作者: Goreham-Voss, Curtis M.;Hyde, Philip J.;Hall, Richard M.;Fisher, John;Brown, Thomas D.
• 通讯作者: Brown, Thomas D.

The accuracy and precision of a micro computer tomography volumetric measurement technique for the analysis of in-vitro tested total disc replacements.

用于分析体外测试的全椎间盘置换物的微型计算机断层扫描体积测量技术的准确性和精密度。

• DOI: 10.1243/09544119jeim515
• 发表时间: 2009
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Vicars,R;Fisher,J;Hall,RM
• 通讯作者: Hall,RM

Interaction of micron and nano-sized particles with cells of the dura mater.

• DOI: 10.1002/jbm.b.33129
• 发表时间: 2014-10
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
• 影响因子: 3.4
• 作者: Papageorgiou, Iraklis;Marsh, Rainy;Tipper, Joanne L.;Hall, Richard M.;Fisher, John;Ingham, Eileen
• 通讯作者: Ingham, Eileen