Wear Analysis of Intervertebral Total Disc Replacements

全椎间盘置换术的磨损分析

• 批准号: 7811049
• 负责人: THOMAS DUDLEY BROWN
• 金额: $ 21.61万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7811049
• 关键词: Accounting; Area; Behavior; Biological Preservation; Biomedical Engineering; Caliber; Calibration; Charities; Classification; Clinical; Communities; Complex; Complication; Computer Simulation; Couples; Data; Dependency; Devices; Drug Formulations; Equipment; Europe; Exhibits; Face; Failure; Funding; Future; Goals; Implant; Joints; Kinetics; Lubrication; Measurement; Mechanics; Metals; Methodology; Modeling; Motion; Operative Surgical Procedures; Parents; Pattern; Phase; Polyethylenes; Process; Protocols documentation; Recovery; Research; Resources; Running; Series; Solid; Speed; Spinal Cord; Surface; Surgeon; Techniques; Testing; United States National Institutes of Health; Vertebral column; Work; abstracting; base; design; engineering design; experience; improved; in vivo; interest; intervertebral disk degeneration; kinematics; novel; parent grant; patient population; pre-clinical; pressure; public health relevance; research study; simulation

DESCRIPTION (provided by applicant): Project Summary/Abstract Intervertebral total disc replacement (TDR) implants potentially herald a paradigm shift in the management of degenerative disc disease. Preservation of motion may avoid adjacent-segment degeneration, a well- recognized complication of fusion. Based on encouraging experience in Europe and subsequent FDA approvals in 2004 and 2005, the Charity III and ProDisc TDR devices have come into clinical use by many spine surgeons in the US. As an alternative to fusion (~300,000/year in the U.S.), there is substantial interest in increasingly wide usage of this class of devices. However, the potential for late wear-related complications is disconcerting. Both Chariti and ProDisc involve metal-on-conventional-polyethylene bearings, and the TDR patient population is a decade younger than for THR/TKR. Moreover, owing to close proximity of the spinal cord, the potential consequences of implant failure are substantially more dire than for THR/TKR. It is crucial that the scientific community expeditiously confront the issue of TDR wear. A Bioengineering Research Partnership supported by the parent grant is working to provide a firm scientific basis for identifying and dealing with wear-related problems in TDR. This parent grant research (Notice Number NOT-OD-09-058 titled NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications) involves developing techniques for TDR wear assessment in the pre-clinical phase (Aim 1), implementing a novel technique for in vivo TDR radiographic wear measurement (Aim 2), and assessing the functional biologic activity of TDR wear debris (Aim 3). A revision to the parent grant is proposed to expand and improve upon the computational wear simulation aspects under study in parent Specific Aim 1. The goal of the proposed revision research is to identify methodology by means of which the experimentally-sourced tribologic wear factors used in TDR computational wear simulations can be realistically determined from independently conducted pin-on- plate wear tests, to avoid the need for calibration/linkage to already-performed TDR physical wear simulations. This will open the way to expedited computational simulations of substantively different TDR designs, and to testing of novel hypotheses related to TDR wear, that otherwise would not be possible. PUBLIC HEALTH RELEVANCE: Project Narrative Relevance: Computer simulation of the wear of total disc replacement implants has great usefulness both for engineering design purposes and for surgical assessments. Revision research is proposed for ways to make these computer simulations more accurate and more versatile, by means of better accuracy of one of the key pieces of experimental information (known as the wear factor) needed as input information for these simulations.

描述（由申请人提供）：项目摘要/摘要椎间盘置换式置换（TDR）植入可能会预示退行性椎间盘疾病管理的范式转移。保持运动可以避免相邻的段变性，这是融合的公认并发症。基于欧洲的令人鼓舞的经验以及2004年和2005年的FDA批准，慈善机构III和Prodisc TDR设备已用于美国许多脊柱外科医生的临床用途。作为融合的替代方案（在美国约300,000个/年），对于越来越广泛使用此类设备，人们对此充满了兴趣。但是，与晚期磨损有关的并发症的潜力令人不安。 Chariti和Prodisc均涉及金属固定的聚丙烯轴承，而TDR患者人群比THR/TKR年轻十岁。此外，由于脊髓的紧密距离，植入物衰竭的潜在后果比THR/TKR更可怕。至关重要的是，科学界迅速面对TDR磨损问题。父母赠款支持的生物工程研究伙伴关系正在努力为识别和处理与磨损相关的TDR中的问题提供牢固的科学依据。 This parent grant research (Notice Number NOT-OD-09-058 titled NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications) involves developing techniques for TDR wear assessment in the pre-clinical phase (Aim 1), implementing a novel technique for in vivo TDR radiographic wear measurement (Aim 2), and assessing the functional biologic activity of TDR wear debris (Aim 3). A revision to the parent grant is proposed to expand and improve upon the computational wear simulation aspects under study in parent Specific Aim 1. The goal of the proposed revision research is to identify methodology by means of which the experimentally-sourced tribologic wear factors used in TDR computational wear simulations can be realistically determined from independently conducted pin-on- plate wear tests, to avoid the need for calibration/linkage to already-performed TDR physical wear simulations.这将为加快实质性TDR设计的计算模拟以及与TDR磨损相关的新假设进行测试开辟道路。 公共卫生相关性：项目叙事相关性：对全盘置换植入物的磨损的计算机模拟在工程设计目的和手术评估中都具有极大的用处。提出了修订研究，以使这些计算机模拟更准确，更通用的方法，这是通过更好的准确性（称为磨损因子）作为这些模拟的输入信息所需的一项关键的实验信息（称为磨损因子）。

项目成果

The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement.

• DOI: 10.1097/brs.0b013e31823cbd6e
• 发表时间: 2012-04-20
• 期刊: Spine
• 影响因子: 3
• 作者: Vicars R;Prokopovich P;Brown TD;Tipper JL;Ingham E;Fisher J;Hall RM
• 通讯作者: Hall RM

Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells

• DOI: 10.1016/j.biomaterials.2013.01.023
• 发表时间: 2013-05-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Behl, Bharat;Papageorgiou, Iraklis;Ingham, Eileen
• 通讯作者: Ingham, Eileen

Cross-shear implementation in sliding-distance-coupled finite element analysis of wear in metal-on-polyethylene total joint arthroplasty: intervertebral total disc replacement as an illustrative application.

• DOI: 10.1016/j.jbiomech.2010.03.003
• 发表时间: 2010-06-18
• 期刊: JOURNAL OF BIOMECHANICS
• 影响因子: 2.4
• 作者: Goreham-Voss, Curtis M.;Hyde, Philip J.;Hall, Richard M.;Fisher, John;Brown, Thomas D.
• 通讯作者: Brown, Thomas D.

The accuracy and precision of a micro computer tomography volumetric measurement technique for the analysis of in-vitro tested total disc replacements.

用于分析体外测试的全椎间盘置换物的微型计算机断层扫描体积测量技术的准确性和精密度。

• DOI: 10.1243/09544119jeim515
• 发表时间: 2009
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Vicars,R;Fisher,J;Hall,RM
• 通讯作者: Hall,RM

Interaction of micron and nano-sized particles with cells of the dura mater.

• DOI: 10.1002/jbm.b.33129
• 发表时间: 2014-10
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
• 影响因子: 3.4
• 作者: Papageorgiou, Iraklis;Marsh, Rainy;Tipper, Joanne L.;Hall, Richard M.;Fisher, John;Ingham, Eileen
• 通讯作者: Ingham, Eileen