Hand-held optical imager for breast cancer imaging

用于乳腺癌成像的手持式光学成像仪

• 批准号: 8545922
• 负责人: ANURADHA GODAVARTY
• 金额: $ 6.08万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8545922
• 关键词: Affect; Algorithms; Bilateral; Biomedical Engineering; Biopsy; Breast; Clinical; Computer software; Contrast Media; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Early Diagnosis; Effectiveness; Environment; Florida; Future; Generations; Gold; Grant; Hand; Hand functions; Housing; Image; Imaging technology; International; Laboratories; Light; Lighting; Location; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammography; Measurement; Methods; Modality; Noise; Nuclear; Operative Surgical Procedures; Optics; Patients; Performance; Positron-Emission Tomography; Research; Research Design; Signal Transduction; Staging; Study Subject; Surface; Surgeon; Survival Rate; Technology; Time; Tissues; Translations; Tumor stage; Ultrasonography; United States; Universities; Woman; Work; base; breast cancer diagnosis; cancer imaging; cancer therapy; design; flexibility; high risk; imaging modality; improved; in vivo; innovation; malignant breast neoplasm; novel; optical imaging; prognostic; reconstruction; response; tissue phantom; tool; tumor; young woman

DESCRIPTION (provided by applicant): Early-stage diagnosis of breast cancer is essential for improving the survival rate of women affected (1 in 8) in the United States. Near-infrared (NIR) optical imaging is a non-invasive and non-ionizing modality that is emerging as a diagnostic tool for breast cancer. In recent years, hand-held based optical imagers developed towards clinical translation of the technology are not capable of contouring along tissue curvatures, nor perform three-dimensional (3D) tomographic imaging to diagnose deep and/or early stage tumors. The overall objective of the proposed work is to implement the recently developed portable cart-based hand-held optical imager for tissue phantom and in-vivo breast imaging studies (in normal and breast cancer subjects), in order to demonstrate near-real time 2D tumor detection and 3D tomographic analysis, towards breast cancer diagnosis. The specific aims include: (i) Demonstrate real-time simultaneous bilateral breast imaging in tissue phantoms and in-vivo, using a novel hand-held optical imager, in order to detect tumor-mimicking targets in near real-time. (ii) Demonstrate the feasibility of 3D target localization in tissue phantoms and in-vivo, via 3D tomographic imaging studies using the hand-held optical imager; and (iii) Determine the effectiveness of tumor detection in breast cancer subjects using the hand-held optical imager, in comparison to the gold-standard x- ray mammography. The hypothesis of the application relies on a three-fold innovative implementation: (i) the "forked" probe design aids in performing simultaneous bilateral imaging of both the breast tissues, in order to improve the signal-to-noise (SNR) ratio between the normal and diseased tissue; (ii) co-registered measurements using a hand-held probe on any tissue volume and curvature aids in near real-time target detections as well as 3D tomographic imaging; and (iii) simultaneous illumination and detection at multiple locations on the tissue will allow rapid imaging time, appropriate for a clinical environment. The study design involves the following: (i) Perform simultaneous bilateral imaging on breast phantoms, in-vivo on healthy and breast cancer subjects to determine the effectiveness of 2D target (tumor) detectability with maximum SNR. (ii) Implement a coregistered imaging approach to obtain positional information of the probe(s) towards 3D tomographic analysis in phantom and in-vivo. (iii) Determine the 3D target (tumor) location(s) via tomographic analysis in phantoms and in-vivo; and (iv) Compare the optical images to the gold standard x-ray mammography images in breast cancer subject studies, in order to assess the feasibility of the hand-held optical imager in a clinical environment. The proposed research significantly impacts by accelerating the clinical translation of the emerging optical imaging technology towards early-stage breast cancer diagnosis, due to the unique and innovative method of 3D target localization using a portable and inexpensive hand-held optical imager. The technology also has potential towards prognostic breast imaging, image-guided breast cancer therapy, and volumetric analysis of tumors in response to chemotherapeutic trials.

描述（由申请人提供）：乳腺癌的早期诊断对于改善美国受影响的妇女的存活率至关重要。近红外（NIR）光学成像是一种非侵入性和非电离模态，它是作为乳腺癌的诊断工具而出现的。近年来，针对该技术的临床翻译而开发的基于手持的光学成像仪无法沿组织曲率轮廓，也不能执行三维（3D）断层扫描成像以诊断深层和/或早期阶段肿瘤。拟议工作的总体目标是实施最近开发的基于便携式车的手持光学成像仪，用于组织幻影和体内乳房成像研究（在正常和乳腺癌受试者中），以证明接近现实的时间2D肿瘤检测和3D肿瘤检测和3D断层扫描分析，用于乳腺癌诊断。具体目的包括：（i）使用一种新型的手持光学成像仪在组织幻像和体内进行实时同时进行双侧乳房成像，以便在接近实时地检测模仿肿瘤的靶标。 （ii）通过使用手持光学成像仪的3D断层摄影成像研究，证明了3D目标定位在组织幻像和体内的可行性； （iii）与金色标准的X射线乳房摄影相比，使用手持光学成像仪确定肿瘤检测在乳腺癌受试者中的有效性。该应用的假设依赖于三倍的创新实现：（i）“分叉”的探针设计有助于对两种乳腺组织的同时进行双侧成像，以提高正常组织和患病组织之间的信噪比（SNR）比率； （ii）在接近实时目标检测中以及3D断层扫描成像中，使用手持探针对任何组织体积和曲率辅助的共同测量； （iii）在组织上的多个位置同时照明和检测将允许快速成像时间，适合临床环境。研究设计涉及以下内容：（i）对乳房幻像进行同时进行双侧成像，对健康和乳腺癌受试者的体内，以确定2D靶标（肿瘤）可检测性使用最大SNR的有效性。 （ii）实施一种核心成像方法，以获取探针的位置信息，以涉及幻影和体内3D断层扫描分析。 （iii）通过幻影和体内的层析成像分析确定3D目标（肿瘤）位置； （iv）将光学图像与乳腺癌主题研究中的金标准X射线乳房X线摄影图像进行比较，以评估临床环境中手持光学成像仪的可行性。拟议的研究通过将新兴的光学成像技术的临床翻译加速到早期乳腺癌诊断，从而显着影响，这是由于使用便携式和廉价的手持光学成像仪的独特和创新的3D目标定位方法。该技术还具有预后的乳房成像，图像引导的乳腺癌治疗以及对化学治疗试验的肿瘤的体积分析。

项目成果

Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies.

• DOI: 10.1364/ao.48.006408
• 发表时间: 2009-11-20
• 期刊: Applied optics
• 影响因子: 1.9
• 作者: Ge J;Erickson SJ;Godavarty A
• 通讯作者: Godavarty A

Improved detection limits using a hand-held optical imager with coregistration capabilities.

• DOI: 10.1364/boe.1.000126
• 发表时间: 2010-07-15
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Erickson SJ;Martinez SL;Gonzalez J;Caldera L;Godavarty A
• 通讯作者: Godavarty A

Noninvasive Surface Imaging of Breast Cancer in Humans using a Hand-held Optical Imager.

使用手持式光学成像仪对人类乳腺癌进行无创表面成像。

• DOI: 10.1088/2057-1976/1/4/045001
• 发表时间: 2015
• 期刊: Biomedical physics & engineering express
• 影响因子: 1.4
• 作者: Erickson-Bhatt,SarahJ;Roman,Manuela;Gonzalez,Jean;Nunez,Annie;Kiszonas,Richard;Lopez-Penalver,Cristina;Godavarty,Anuradha
• 通讯作者: Godavarty,Anuradha

Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager.

• DOI: 10.1088/0031-9155/58/5/1563
• 发表时间: 2013-03-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Erickson SJ;Martinez SL;DeCerce J;Romero A;Caldera L;Godavarty A
• 通讯作者: Godavarty A

Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies.

第二代手持式光学成像仪的分辨率：漫反射和荧光成像研究。

• DOI: 10.1364/ao.52.008060
• 发表时间: 2013
• 期刊: Applied optics
• 影响因子: 1.9
• 作者: Roman,Manuela;Gonzalez,Jean;Carrasquilla,Jennifer;Erickson,SarahJ;Akhter,Rad;Godavarty,Anuradha
• 通讯作者: Godavarty,Anuradha