Image Quality Improvement and Breast Compression Reduction in Breast Tomosynthesi

乳房断层合成中的图像质量改善和乳房压迫减少

• 批准号: 8217892
• 负责人: Ioannis Sechopoulos
• 金额: $ 29.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-08 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8217892
• 关键词: Address; Adherence; American Cancer Society; Appearance; Behavior; Breast; Breast Cancer Detection; Breast Cancer Early Detection; Breast-Conserving Surgery; Callback; Canada; Clinical; Computer software; Computer-Assisted Diagnosis; Coupled; Detection; Diagnosis; Dimensions; Disease; Dose; Early Diagnosis; Europe; Future; Guidelines; Image; Image Analysis; Imaging Techniques; Imaging technology; Lesion; Malignant Neoplasms; Mammaplasty; Mammography; Masks; Mastectomy; Medical Imaging; Methods; Nature; Noise; Normal tissue morphology; Pain; Patients; Procedures; Process; Radiation; Reporting; Research Project Grants; Risk Assessment; Screening Result; Screening procedure; Sensitivity and Specificity; Specificity; Surveys; Techniques; Technology; Testing; Tissues; Woman; Work; X-Ray Computed Tomography; base; breast cancer diagnosis; cancer imaging; cancer risk; digital; image processing; improved; interest; malignant breast neoplasm; model development; mortality; novel; radiologist; two-dimensional

DESCRIPTION (provided by applicant): Breast cancer is the most prevalent non-skin cancer in women in the US. To increase the early detection of breast cancer, annual screening mammography has been recommended for asymptomatic patients. However, mammography is not without limitations. The superposition of glandular tissue is an inherent consequence of the two dimensional nature of mammography, and may result in the masking of lesions of interest (reducing sensitivity) or the false appearance of overlapping normal tissues as lesions (reducing specificity). Digital tomosynthesis of the breast is a novel x-ray based imaging technique being investigated to replace mammography for the early detection and diagnosis of breast cancer. Tomosynthesis is based on the concept of limited angle computed tomography, in which projections of the imaged object acquired from a limited angular range give enough information to partially reconstruct that object in three dimensions. Reports indicate that tomosynthesis reduces callback rate (increasing specificity) and increases detection rate (increasing sensitivity) compared to mammography. However, in current implementations of breast tomosynthesis, the breast undergoes the same vigorous compression as that used in mammography. It has been shown that the pain resulting from this vigorous breast compression during mammography is an important factor in women not undergoing the recommended annual screening mammography. This reduction in screening adherence results in an increase in breast cancer mortality and in a reduction in treatment options, yielding a higher number of mastectomies as opposed to breast conserving surgeries. The objective of this research project is to develop and test new image acquisition and processing techniques that will allow for the acquisition of breast tomosynthesis images with a substantial reduction in the amount of breast compression used with no loss in image quality or increase in radiation dose. For this, we will (1) develop a method to reduce the impact of x-ray scatter on image quality; (2) develop new image acquisition techniques for reduced compression tomosynthesis that result in the same radiation dose and image noise levels as standard tomosynthesis; (3) compare the image quality between standard tomosynthesis and reduced compression tomosynthesis performed with the techniques developed in this project. Successful completion of this project will result in the ability to perform breast tomosynthesis imaging with substantially reduced breast compression levels, with no increase in radiation dose, and no loss in image quality and tissue coverage. This will result in a reduction in the pain associated with breast cancer screening, resulting in an increase in screening adherence by women, which will decrease breast cancer mortality and increase the number of cases in which breast conserving surgery can be performed. PUBLIC HEALTH RELEVANCE: Tomosynthesis imaging of the breast is being developed to overcome mammography's two-dimensional nature, which significantly impacts its sensitivity and specificity, hampering the early detection of breast cancer. Currently, breast tomosynthesis imaging involves the same vigorous compression of the patient's breast during image acquisition as that used in mammography. In this project we will develop the methods necessary to substantially reduce the amount of breast compression used in tomosynthesis, resulting in a substantial reduction in the pain associated with this procedure with no loss in image quality or increase in radiation dose to the breast. This will result in a higher breast cancer screening adherence, resulting in a higher early detection rate, increasing both breast cancer survival and breast conserving surgery rates.

描述（由申请人提供）：乳腺癌是美国女性中最普遍的非皮肤癌。为了增加对乳腺癌的早期检测，建议无症状患者进行年度筛选乳房摄影。但是，乳房X线摄影并非没有局限性。腺组织的叠加是乳房X线摄影的二维性质的固有结果，可能导致掩盖感兴趣的病变（降低敏感性）或重叠正常组织作为病变（降低特异性）的错误外观。乳房的数字间压合成是一种新型基于X射线的成像技术，以取代乳腺摄影以早期检测和诊断乳腺癌。 Tomosynthesis基于有限的角度计算机断层扫描的概念，其中从有限的角度范围获得的成像对象的投影提供了足够的信息，以部分重建三维对象。报告表明，与乳房X线摄影相比，断层合成降低了回调率（提高特异性），并提高了检测率（提高敏感性）。然而，在当前乳房合成的实施中，乳房经历了与乳房X线摄影相同的剧烈压缩。已经表明，乳房X线摄影过程中这种剧烈的乳房压缩引起的疼痛是女性不参加建议的年度诊所乳房X线摄影的重要因素。筛查依从性的这种降低导致乳腺癌死亡率的增加和治疗选择的降低，与乳房保存手术相反，乳腺切除术数量更高。 该研究项目的目的是开发和测试新的图像采集和加工技术，该技术将允许获取乳房间歇合成图像，并大大减少了乳房压缩的量，而没有图像质量损失或辐射剂量的增加。为此，我们将（1）开发一种减少X射线散射对图像质量的影响的方法； （2）开发新的图像采集技术，以减少压缩性间隔，从而导致与标准的质合成相同的辐射剂量和图像噪声水平； （3）比较标准的间歇合成与减少的压缩性间隔之间的图像质量，并在该项目中开发的技术进行了比较。 该项目的成功完成将导致能够进行乳房合成成像，并大大降低乳房压缩水平，而没有增加辐射剂量，并且图像质量和组织覆盖率没有损失。这将导致与乳腺癌筛查相关的疼痛减轻，从而导致女性筛查的依从性增加，这将降低乳腺癌的死亡率并增加可以进行乳房保存手术的病例。 公共卫生相关性：正在开发乳房的乳房合成成像，以克服乳房X线摄影的二维性质，从而显着影响其敏感性和特异性，从而阻碍了对乳腺癌的早期发现。目前，乳房间压成像在图像获取过程中涉及对患者乳腺的剧烈压缩，与乳房X线摄影相同。在这个项目中，我们将开发出必要的方法，以实质性地减少在整齐合成中使用的乳房压缩量，从而大大减轻与该程序相关的疼痛，而不会损失图像质量或辐射剂量增加对乳房的损失。这将导致较高的乳腺癌筛查依从性，从而导致较高的早期检测率，从而增加乳腺癌的存活率和乳房保存手术率。