Improved Dehydration Process for Pharmaceutical Synthesis II

药物合成脱水工艺的改进 II

基本信息

批准号：
8323263
负责人：
Andrew Feiring
金额：
$ 48.2万
依托单位：
COMPACT MEMBRANE SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2016-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Compact Membrane Systems (CMS) proposes to develop a perfluoro membrane reactor technology that will provide a generally applicable tool for removing water and oxygen from pharmaceutical synthesis processes. This innovation aims to improve product quality and reduce manufacturing costs of pharmaceutical end products. Manufacturing cost reductions will be derived from improved product yields, increased reaction rates and reduced energy input requirements of the manufacturing process. Product quality improvements will be derived from the elimination of entrainers, azeotropic distillation, and drying reagents in the process as well as operation at lower temperatures and driving the reactant. The project has been expanded to include the removal of both oxygen and water in an effort to reduce side reactions and/or catalyst poisoning which should be of broad use in pharmaceutical synthesis. This membrane system has the capability to withstand process temperatures of 2200C endowing it with universal applicability in almost any organic-water environment for water separation in the synthesis of products such as sildenafil, celecoxib, sertraline, and aprepitant. Given the large water-organic compound separation factors achievable, the inertness of the membrane, and the ability to withstand harsh operating conditions, we believe we have an ideal system for reaction water and oxygen removal. The proposer will develop the membrane system and processes while the subcontractors will demonstrate Pd-catalyzed amination reactions. These reactions have revolutionized drug discovery and process chemistry in the past decade. The efficiency of Pd-catalyzed amination reactions can be negatively affected by impurities such as water. The Fox group at the University of Delaware and recently hired synthesis chemists at CMS (and consultants) will demonstrate the efficacy of the membrane process in Pd-catalyzed amination reactions in a study that will consist of: synthesis of the aryl bromide intermediate from the Astra Zeneca AR-A2 process; synthesis of the Pd-catalyzed amination product from the AR-A2 process; development of GC assays for the reactions; study of a control reaction without water/oxygen removal; and, study of amination with drying of the aryl bromide intermediate using the proprietary membrane. With success in Phase I, numerous industrial partners have either already spent over $150,000 on evaluation or committed to major evaluations in Phase II.

描述（由申请人提供）：紧凑型膜系统（CMS）提议开发一种全氟膜反应器技术，该技术将提供一种普遍适用的工具，用于从药物合成过程中去除水和氧。这项创新旨在提高产品质量并降低制药最终产品的制造成本。制造成本的降低将源于产品产量的提高、反应速率的提高以及制造过程中能量输入需求的减少。产品质量的改进将源自工艺中夹带剂、共沸蒸馏和干燥试剂的消除以及较低温度下的操作和驱动反应物。该项目已扩大到包括去除氧气和水，以减少副反应和/或催化剂中毒，这应该在药物合成中广泛使用。该膜系统能够承受 2200°C 的工艺温度，使其具有几乎所有有机水环境的普遍适用性，可用于西地那非、塞来昔布、舍曲林和阿瑞吡坦等产品合成中的水分离。考虑到可实现的大水-有机化合物分离因子、膜的惰性以及承受恶劣操作条件的能力，我们相信我们拥有一个理想的反应水和氧气去除系统。提案者将开发膜系统和工艺，而分包商将演示钯催化的胺化反应。这些反应在过去十年中彻底改变了药物发现和过程化学。钯催化的胺化反应的效率可能会受到水等杂质的负面影响。特拉华大学的 Fox 小组和最近聘请的 CMS 合成化学家（和顾问）将在一项研究中展示膜工艺在 Pd 催化胺化反应中的功效，该研究将包括：从 Astra 合成芳基溴中间体Zeneca AR-A2工艺； AR-A2 工艺中 Pd 催化胺化产物的合成；开发反应的 GC 测定法；不去除水/氧的对照反应的研究；并且，使用专有膜干燥芳基溴中间体进行胺化研究。随着第一阶段的成功，许多工业合作伙伴要么已经花费了超过 150,000 美元用于评估，要么承诺在第二阶段进行主要评估。