Resting State Functional Connectivity and Interhemispheric Interactions in Healt*

健康中的静息状态功能连接和半球间相互作用*

基本信息

批准号：
8306256
负责人：
ALEXANDRE R CARTER
金额：
$ 14.43万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8306256
关键词：
Accounting Affect Area Attention Behavior Behavioral Body Regions Body part Brain Brain Injuries Brain Part Brain imaging Brain region Cause of Death Characteristics Clinical Code Communication Contralateral Data Development Plans Doctor of Philosophy Exhibits Eye Movements Functional Imaging Functional Magnetic Resonance Imaging Goals Hand Human Impairment Ipsilateral Lead Lesion Life Magnetic Resonance Imaging Manuals Measures Mentors Molecular Monitor Motor Motor Cortex Movement Neurologist Neuronal Plasticity Neurorehabilitation Neurosciences Noise Patients Performance Preparation Recovery Research Research Activity Research Project Grants Resources Rest Role Saints Side Signal Transduction Site Stroke Survivors System Techniques Testing Training United States Universities Washington body map career career development chronic stroke computational neuroscience disability experience improved indexing information processing insight meetings motor control novel novel strategies public health relevance repaired segregation

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The candidate is an MD/PhD with an excellent background in the molecular and cellular mechanisms of neuronal plasticity whose short-term goal is to make the transition to functional brain imaging and systems neuroscience. The candidate is also a trained clinical neurologist and his long-term career goal is to investigate the human brain's endogenous mechanisms for recovery and self-repair after stroke. The research project is driven by the realization that the dominant localizationist perspective cannot provide the answers we seek to understand brain function. Studying interhemispheric interactions is an important step toward understanding distributed brain networks. Using the novel technique of resting state functional connectivity MRI and traditional fMRI approaches will be an important step in this direction. In particular we hypothesize that resting state functional connectivity MRI can be used as an index ofthe amount of information processing taking place between the hemispheres and predicts behavioral performance. We will test this hypothesis by 1) determining resting connectivity across motor cortex in chronic stroke patients and in professional pianists compared to healthy controls and correlating connectivity with measures of hand dexterity. 2) Resting connectivity across motor cortex representing body parts of capable of different levels of unilateral movement will be studied. 3) BOLD fMRI signals generated in preparation for a unilateral hand movement will be used to study the importance of the ipsilateral BOLD signal for movement preparation and execution. Dr. Carter's career development plan will be mentored by Dr. Maurizio Corbetta, a leader in clinical neurorehabilitation and functional imaging. Consultants chosen for their expertise in functional imaging, motor control systems and computational neuroscience will provide additional guidance. Supervised research activities will be combined with didactic coursework tailored to meet Dr. Carter's needs and provide an intensive training experience. The project will be carried out at Washington University in Saint Louis, a premier site for brain imaging research.

描述（由申请人提供）：项目摘要：候选人是一位医学博士/博士，在神经元可塑性的分子和细胞机制方面拥有出色的背景，其短期目标是向功能性脑成像和系统神经科学过渡。该候选人也是一名训练有素的临床神经学家，他的长期职业目标是研究人脑中风后恢复和自我修复的内源机制。该研究项目是由于认识到占主导地位的本地化观点无法提供我们寻求理解大脑功能的答案而推动的。研究半球间相互作用是理解分布式大脑网络的重要一步。使用静息态功能连接 MRI 新技术和传统功能磁共振成像方法将是朝这个方向迈出的重要一步。特别是，我们假设静息态功能连接 MRI 可用作半球之间发生的信息处理量的指标并预测行为表现。我们将通过以下方式检验这一假设：1）确定慢性中风患者和专业钢琴家与健康对照者运动皮层的静息连接性，并将连接性与手部灵活性测量相关联。 2）将研究代表能够进行不同水平单侧运动的身体部位的运动皮层的静息连接。 3) 在准备单侧手部运动时生成的 BOLD fMRI 信号将用于研究同侧 BOLD 信号对于运动准备和执行的重要性。 Carter 博士的职业发展计划将由临床神经康复和功能成像领域的领导者 Maurizio Corbetta 博士指导。因其在功能成像、运动控制系统和计算神经科学方面的专业知识而被选中的顾问将提供额外的指导。监督研究活动将与专门定制的教学课程相结合，以满足卡特博士的需求并提供强化培训体验。该项目将在圣路易斯华盛顿大学进行，该大学是脑成像研究的首要场所。