2011 Cerebellum Gordon Research Conference

2011年小脑戈登研究会议

• 批准号: 8123666
• 负责人: Kamran Khodakhah
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123666
• 关键词: Ataxia; Autistic Disorder; Basic Science; Behavior; Brain; Cerebellum; Clinical; Cognition; Cognition Disorders; Collaborations; Communities; Discipline; Disease; Dyskinetic syndrome; Dyslexia; Equilibrium; Fertilization; Fostering; Functional disorder; Goals; Growth; Health; Knowledge; London; Mental disorders; Motor; Movement; Movement Disorders; Neurobiology; Neuronal Plasticity; New Hampshire; Oral; Output; Pathway interactions; Relative (related person); Research; Role; Scientist; Series; Structure; Synaptic Transmission; Therapeutic Intervention; Translating; Work; autism spectrum disorder; college; forging; meetings; motor learning; nervous system disorder; neural circuit; posters; relating to nervous system; symposium

DESCRIPTION (provided by applicant): This proposal seeks partial support for a meeting on the Cerebellum as a part of a new Gordon Research Conference series to be held in Colby-Sawyer College in New London, New Hampshire in August of 2011. The cerebellum is the brain structure that carries out the primary function of coordinating movement. Its dysfunction leads to movement disorders which invariably manifest as ataxia and dyskinesia and it has also been implicated in cognitive disorders such as autism and dyslexia. The purpose of the Cerebellum Gordon Research Conference (GRC) is to foster an active dialogue between the very different disciplines and fields that have the cerebellum in common. There is ample evidence that the various cerebellar fields have matured to the extent that facilitating cross-fertilization of ideas amongst them will translate into a significant increase in their rates of growth, and ultimately into a more complete understanding of cerebellar function in health, and dysfunction in disease. Such an advance will further our basic science knowledge of an important brain structure, and is also likely to provide clear targets for therapeutic interventions in cerebellar-induced movement and cognitive disorders. To achieve these goals the Cerebellum GRC will provide the opportunity for the attendees to benefit from over 40 oral presentations on cutting-edge research on the cerebellum given by the best cerebellar scientists and clinicians. In addition, all the attendees will have the opportunity of presenting their own work during one of the four poster sessions. Combined with the educational talks planned to inform the cerebellar community of the role of the cerebellum in various neurologic and mental disorders, the Cerebellum GRC will be an extremely invaluable opportunity for cerebellar scientists to exchange ideas and forge collaborations. PUBLIC HEALTH RELEVANCE: The cerebellum is involved in motor coordination and balance, and its dysfunction is implicated in numerous movement disorders. It is also thought that its dysfunction contributes to cognitive disorders such as dyslexia and autism spectrum disorders. The elegant anatomical circuit of the cerebellum is simple and its role as the neural substrate for certain forms of motor learning is identified. Similarly, cerebellar input-output pathways have been described in detail. Its architectural simplicity, known function and relative accessibility has fostered its scrutiny by neuroscientists from a wide range of disciplines. It is thus not surprising that many scientists believe that the cerebellum presents the best candidate for deciphering higher order brain function. What has been sorely missing to date, however, is a venue where cerebellar scientists from various disciplines gather and exchange information. Thus, while many of the neuroscientists have attended specialized meetings such as those focusing on synaptic transmission, neural circuits & plasticity, computational neurobiology, and even clinical meetings on movement disorders, there have been few (if any) opportunities to discuss the cerebellum as a brain structure responsible for motor coordination and cognition from molecules to behavior. The Cerebellum GRC aims to provide a venue to fill this void.

描述（由申请人提供）：该提案为小脑会议寻求部分支持，这是2011年8月在新罕布什尔州新伦敦的Colby-Sawyer College举行的新戈登研究会议系列的一部分。小脑是小脑进行协调运动的主要功能的大脑结构。它的功能障碍会导致运动障碍，这些运动障碍总是表现为共济失调和运动障碍，并且还与自闭症和阅读障碍等认知障碍有关。小脑戈登研究会议（GRC）的目的是促进具有共同小脑的截然不同的学科和领域之间的积极对话。有足够的证据表明，各个小脑领域已经成熟到促进思想的交叉施肥的程度，将转化为其增长率的显着提高，并最终更完全了解对小脑在健康和功能障碍和功能障碍方面的了解在疾病中。这样的进步将进一步扩大我们对重要大脑结构的基础科学知识，还可能为小脑诱导的运动和认知障碍的治疗干预提供明确的目标。为了实现这些目标，小脑GRC将为与会者提供40多个口头介绍的机会，以对最佳小脑科学家和临床医生提供的小脑研究。此外，所有与会者都有机会在四个海报会议之一中展示自己的作品。结合计划向小脑社区告知小脑在各种神经系统和精神障碍中的作用的教育谈判，小脑GRC将是小脑科学家交流思想和福吉合作的极为宝贵的机会。 公共卫生相关性：小脑与运动协调和平衡有关，其功能障碍与许多运动障碍有关。还认为它的功能障碍会导致诸如阅读障碍和自闭症谱系障碍之类的认知障碍。小脑的优雅解剖回路很简单，它作为某些形式的运动学习形式的神经底物的作用。同样，已经详细描述了小脑输入输出途径。它的建筑简单性，已知功能和相对可及性促进了来自广泛学科的神经科学家的审查。因此，许多科学家认为小脑为破译高级大脑功能的最佳候选者提供了毫不奇怪。然而，迄今为止一直缺少的是一个来自各个学科的小脑科学家收集和交流信息的场所。因此，尽管许多神经科学家都参加了专业会议，例如关注突触传播，神经回路和可塑性，计算神经生物学，甚至有关运动障碍的临床会议的会议，但很少有（如果有）将小脑作为一种讨论小脑的机会大脑结构负责运动协调和从分子到行为的认知。小脑GRC旨在提供一个填补此空隙的场所。