Systematics of medically important Dermacentor tick vectors

医学上重要的 Dermacentor 蜱载体的系统学

基本信息

批准号：
8179788
负责人：
Dmitry A Apanaskevich
金额：
$ 32.75万
依托单位：
GEORGIA SOUTHERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-08 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8179788
关键词：
Animals Applications Grants Arthropods Asians Biology Bite Blood Bovine Anaplasmosis Classification Colorado Tick Fever Competence Crimean Hemorrhagic Fever Culicidae DNA Deposition Dermacentor Disease Domestic Animals Ecology Epidemiology Evolution Family Fever Francisella tularensis Genes Geographic Distribution Geographic Locations Goals Health Personnel Human Internet Investigation Ixodidae Livestock Maps Medical Methods Mitochondria Molecular Monograph Museums North America Nuclear Omsk Hemorrhagic Fever Organism Paper Paralysed Phylogenetic Analysis Phylogeny Prevention Recording of previous events Research Rickettsia Rickettsia rickettsii Rocky Mountain Spotted Fever Scientist Specimen Staging System Testing Theileriasis Tick Control Tick-Borne Diseases Ticks Time Training Trees Tularemia Typhus Vertebrates Virus Wild Animals Work base human disease improved pathogen pet animal tool vector

项目摘要

DESCRIPTION (provided by applicant): Ticks are obligate blood-feeders and temporary ectoparasites of terrestrial vertebrates. Among arthropods, ticks are second only to mosquitoes in transmitting pathogens to humans, pets, livestock, and wild animals. Certain species of the genus Dermacentor are the most important tick-vectors from both the medical and veterinary perspectives; for example, they are vectors of Rickettsia rickettsii causing Rocky Mountain spotted fever; Rickettsia sibirica causing North Asian tick typhus; Rickettsia conori causing Boutenneuse fever; Francisella tularensis causing tularemia in humans; and pathogens causing anaplasmosis, babesioses, and theileriosis in animals. These species also transmit several viruses that cause human diseases. In North America, the bites of some species of Dermacentor can result in paralysis in humans and domestic animals. Correct identification of tick species, particularly in the immature stages, is essential for epidemiology, prevention, and treatment of tick-borne diseases. However, identifying Dermacentor species is challenging because we have no comprehensive work on their systematics; identifying the nymphal and larval stages is almost impossible due to the lack of taxonomic work. The overall objective of the proposed project is to develop a global-scale, comprehensive, and effective tool for identification of Dermacentor species, including their immature stages. This objective will be achieved through four specific aims: Aim 1. To produce a global-scale taxonomic revision of the genus Dermacentor; Aim 2. To produce tools to identify the immature stages of Dermacentor integrating all possible evidence; Aim 3. To develop a DNA barcode system for Dermacentor species; and Aim 4. To reconstruct a phylogeny for Dermacentor species using mitochondrial and nuclear genes. Impact. Identification of tick species is the first and essential step of study and management of tick- borne diseases. Conducted research on systematics of the Dermacentor ticks will allow better understanding of their ecology and geographic distribution which in turn will help in establishing and improving adequate methods of control these tick-vectors. Investigation of the evolutionary history of these ticks will help us to understand the evolution of vector competence and provide a strong basis for establishing a meaningful classification system. Our investigation will be the first of its kind and is fundamental to fulfilling our long-term goals, which are to produce comprehensive identification tools for all tick species of the family Ixodidae. PUBLIC HEALTH RELEVANCE: Ticks in the genus Dermacentor are important vectors of the organisms causing Rocky Mountain spotted fever (Rickettsia rickettsii), North Asian tick typhus (Rickettsia sibirica), Boutenneuse fever (Rickettsia conori), tularemia (Francisella tularensis), Omsk hemorrhagic fever, Colorado tick fever, and Crimean-Congo hemorrhagic fever in humans. Identifying tick species correctly is an essential task for the study of tick vector biology and for the prevention and treatment of tick-borne diseases, but often a challenge work even for a well trained expert. This grant proposal is to develop effective identification tools for the Dermacentor ticks, which intergrade molecular, morphological, host, ecological, geographic, and vector information together and can be used by scientists and professionals in the fields of vector biology and tick-borne diseases.

描述（由申请人提供）：蜱是陆生脊椎动物的专性吸血者和临时体外寄生虫。在节肢动物中，蜱虫在向人类、宠物、牲畜和野生动物传播病原体方面仅次于蚊子。从医学和兽医角度来看，革蜱属的某些物种是最重要的蜱传媒介；例如，它们是引起落基山斑疹热的立克次氏体的载体；西伯利亚立克次体引起北亚蜱斑疹伤寒；康氏立克次体引起布特讷讷热；土拉弗朗西斯菌引起人类兔热病；以及引起动物无形体病、巴贝斯虫病和泰勒虫病的病原体。这些物种还传播多种导致人类疾病的病毒。在北美，某些皮肤革螨的叮咬会导致人类和家畜瘫痪。正确识别蜱种，特别是在未成熟阶段，对于蜱传疾病的流行病学、预防和治疗至关重要。然而，鉴定 Dermacentor 物种具有挑战性，因为我们没有对其系统学进行全面的研究；由于缺乏分类学工作，识别若虫和幼虫阶段几乎是不可能的。拟议项目的总体目标是开发一种全球范围的、全面的、有效的工具来识别皮肤革虫物种，包括其未成熟阶段。这一目标将通过四个具体目标来实现：目标 1. 对 Dermacentor 属进行全球范围的分类学修订；目标 2. 整合所有可能的证据，开发工具来识别 Dermacentor 的不成熟阶段；目标 3. 开发 Dermacentor 物种的 DNA 条形码系统；目标 4. 使用线粒体和核基因重建皮肤革螨物种的系统发育。影响。蜱种鉴定是蜱传疾病研究和管理的第一步，也是必不可少的一步。对皮肤蜱的系统学进行的研究将有助于更好地了解其生态和地理分布，从而有助于建立和改进控制这些蜱媒介的适当方法。研究这些蜱虫的进化历史将有助于我们了解媒介能力的进化，并为建立有意义的分类系统提供坚实的基础。我们的研究将是此类研究中的首次，对于实现我们的长期目标至关重要，我们的长期目标是为蜱科的所有蜱种提供全面的识别工具。公共卫生相关性：皮肤蜱属蜱是导致落基山斑疹热（立克次氏立克次体）、北亚蜱斑疹伤寒（西伯利亚立克次体）、肉毒杆菌热（康诺立克次体）、土拉热病（土拉热弗朗西斯菌）和鄂木斯克出血热的重要媒介。、科罗拉多蜱热和克里米亚-刚果人类出血热。正确识别蜱虫种类是蜱虫媒介生物学研究和蜱传疾病预防和治疗的一项重要任务，但即使对于训练有素的专家来说，这也是一项艰巨的任务。该拨款提案旨在开发有效的皮肤蜱识别工具，将分子、形态、宿主、生态、地理和媒介信息整合在一起，可供媒介生物学和蜱传疾病领域的科学家和专业人员使用。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Microtomography of the Baltic amber tick Ixodes succineus reveals affinities with the modern Asian disease vector Ixodes ovatus.

DOI：
10.1186/s12862-016-0777-y
发表时间：
2016-10-10
期刊：
BMC evolutionary biology
影响因子：
3.4
作者：
Dunlop JA;Apanaskevich DA;Lehmann J;Hoffmann R;Fusseis F;Ehlke M;Zachow S;Xiao X
通讯作者：
Xiao X

Reinstatement of Dermacentor kamshadalus Neumann (Acari: Ixodidae) as a valid species parasitizing mountain goats and sheep in the United States, Canada, and Russia.

恢复 Dermacentor kamshadalus Neumann（螨虫：蜱科）在美国、加拿大和俄罗斯作为寄生山羊和绵羊的有效物种。

DOI：
10.1603/me12278
发表时间：
2013
期刊：
Journal of medical entomology
影响因子：
2.1
作者：
Apanaskevich,DmitryA
通讯作者：
Apanaskevich,DmitryA

First description of the immature stages and redescription of the adults of Cosmiomma hippopotamensis (Acari: Ixodidae) with notes on its bionomics.

对 Cosmiomma hippopotamensis（螨虫：蜱科）成虫的未成熟阶段的首次描述和重新描述，并附有其生物学注释。

DOI：
10.1603/me12271
发表时间：
2013
期刊：
Journal of medical entomology
影响因子：
2.1
作者：
Apanaskevich,DmitryA;Walker,JaneB;Heyne,Heloise;Bezuidenhout,JDürr;Horak,IvanG
通讯作者：
Horak,IvanG

Redescription of Amblyomma integrum adults and immature stages.

重新描述完整钝眼虫成虫和未成熟阶段。